Study protocol for the PURSUIT-HFpEF study: A Prospective, Multicenter, Observational Study of Patients with Heart Failure with Preserved Ejection Fraction

Suna, Shinichiro; Hikoso, Shungo; Yamada, Takahisa; Uematsu, Masaaki; Yasumura, Yoshio; Nakagawa, Akito; Takeda, Toshihiro; Kojima, Takayuki; Kida, Hirota; Oeun, Bolrathanak; Sunaga, Akihiro; Kitamura, Tetsuhisa; Dohi, Tomoharu; Okada, Katsuki; Mizuno, Hiroya; Nakatani, Daisaku; Iso, Hiroyasu; Matsumura, Yasushi; Sakata, Yasushi

doi:https://doi.org/10.1136/bmjopen-2020-038294

Study protocol for the PURSUIT-HFpEF study: A Prospective, Multicenter, Observational Study of Patients with Heart Failure with Preserved Ejection Fraction

Suna, Shinichiro; Hikoso, Shungo; Yamada, Takahisa et al.

BMJ Open, 2020, 10(10), e038294

Number of Access:431（2025-04-30 13:07 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/78366

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Title	Study protocol for the PURSUIT-HFpEF study: A Prospective, Multicenter, Observational Study of Patients with Heart Failure with Preserved Ejection Fraction
Creator	NRID 1000040573085 1000040573085 CreatorName Suna, Shinichiro
	NRID 1000030423164 1000030423164 researchmap permalink hikoso_osakauniv hikoso_osakauniv Scopus Author ID 6507288830 6507288830 CreatorName Hikoso, Shungo
	CreatorName Yamada, Takahisa
	NRID 1000000270728 1000000270728 CreatorName Uematsu, Masaaki
	CreatorName Yasumura, Yoshio
	CreatorName Nakagawa, Akito
	NRID 1000070506493 1000070506493 researchmap permalink ttakeda_research ttakeda_research Scopus Author ID 7403572788 7403572788 CreatorName Takeda, Toshihiro
	CreatorName Kojima, Takayuki
	CreatorName Kida, Hirota
	CreatorName Oeun, Bolrathanak
	CreatorName Sunaga, Akihiro
	NRID 1000030639810 1000030639810 ORCID 0000-0003-0107-0580 0000-0003-0107-0580 researchmap permalink Kitamura_T Kitamura_T Scopus Author ID 22234282700 22234282700 CreatorName Kitamura, Tetsuhisa
	NRID 1000090838137 1000090838137 researchmap permalink dohi_1230 dohi_1230 Scopus Author ID 35071263000 35071263000 CreatorName Dohi, Tomoharu
	NRID 1000020776489 1000020776489 researchmap permalink katsuki_okada katsuki_okada Scopus Author ID 13613369100 13613369100 CreatorName Okada, Katsuki
	NRID 1000060437423 1000060437423 CreatorName Mizuno, Hiroya
	NRID 1000060444535 1000060444535 researchmap permalink dsyma dsyma Scopus Author ID 6603545219 6603545219 CreatorName Nakatani, Daisaku
	NRID 1000050223053 1000050223053 CreatorName Iso, Hiroyasu
	NRID 1000090252642 1000090252642 CreatorName Matsumura, Yasushi
	NRID 1000000397671 1000000397671 ORCID 0000-0002-5618-4721 0000-0002-5618-4721 researchmap permalink C4589 C4589 Scopus Author ID 35395964700 35395964700 CreatorName Sakata, Yasushi
Subject	cardiac epidemiology
	cardiology
	heart failure
Description	Suna S, Hikoso S, Yamada T On behalf of the OCVC-Heart Failure Investigators, et al. Study protocol for the PURSUIT-HFpEF study: a Prospective, Multicenter, Observational Study of Patients with Heart Failure with Preserved Ejection Fraction. BMJ Open 2020;10:e038294. doi: 10.1136/bmjopen-2020-038294
Abstract	Introduction Neither the pathophysiology nor an effective treatment for heart failure with preserved ejection fraction (HFpEF) has been elucidated to date. The purpose of this ongoing study is to elucidate the pathophysiology and prognostic factors for patients with HFpEF admitted to participating institutes. We also aim to obtain insights into the development of new diagnostic and treatment methods by analysing patient background factors, clinical data and follow-up information. Methods and analysis This study is a prospective, multicentre, observational study of patients aged ≥20 years admitted due to acute decompensated heart failure with preserved left ventricular ejection fraction (≥50%) and elevated N-terminal-pro brain natriuretic peptide (NT-proBNP) (≥400 pg/mL). The study began in June 2016, with the participation of Osaka University Hospital and 31 affiliated facilities. We will collect data on history in detail, accompanying diseases, quality of life, frailty score, medication history, and laboratory and echocardiographic data. We will follow-up each patient for 5 years, and collect outcome data on mortality, cause of death, and the number and cause of hospitalisation. The target number of registered cases is 1500 cases in 5 years. Ethics and dissemination The protocol was approved by the Institutional Review Board (IRB) of Osaka University Hospital on 24 February 2016 (ID: 15471), and by the IRBs of the all participating facilities. The findings will be disseminated through peer-reviewed publications and conference presentations.
Publisher	BMJ Publishing Group
Source Title	BMJ Open
Volume (Issue)	10(10)
Page	e038294
Date of Issued	2020-10-15
Language	English
Handle URL	https://hdl.handle.net/11094/78366
eISSN	20446055
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1136/bmjopen-2020-038294
Relation.isIdenticalTo	PMID 33060085
Access Rights	open access
CopyRight	© 2020 Author(s) (or their employer(s)). This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCMI Type	Text
DCTERMS.bibliographicCitation	BMJ Open. 2020, 10(10), p. e038294
DC.title	Study protocol for the PURSUIT-HFpEF study: A Prospective, Multicenter, Observational Study of Patients with Heart Failure with Preserved Ejection Fraction
DC.creator	Suna, Shinichiro
	Hikoso, Shungo
	Yamada, Takahisa
	Uematsu, Masaaki
	Yasumura, Yoshio
	Nakagawa, Akito
	Takeda, Toshihiro
	Kojima, Takayuki
	Kida, Hirota
	Oeun, Bolrathanak
	Sunaga, Akihiro
	Kitamura, Tetsuhisa
	Dohi, Tomoharu
	Okada, Katsuki
	Mizuno, Hiroya
	Nakatani, Daisaku
	Iso, Hiroyasu
	Matsumura, Yasushi
	Sakata, Yasushi
DC.publisher	BMJ Publishing Group
DC.language' scheme='DCTERMS.RFC1766	English
DC.type' scheme='DCTERMS.DCMIType	Text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2020-10-15
DC.identifier	https://doi.org/10.1136/bmjopen-2020-038294
DC.subject	cardiac epidemiology
	cardiology
	heart failure
DC.description	Suna S, Hikoso S, Yamada T On behalf of the OCVC-Heart Failure Investigators, et al. Study protocol for the PURSUIT-HFpEF study: a Prospective, Multicenter, Observational Study of Patients with Heart Failure with Preserved Ejection Fraction. BMJ Open 2020;10:e038294. doi: 10.1136/bmjopen-2020-038294
DCTERMS.abstract	Introduction Neither the pathophysiology nor an effective treatment for heart failure with preserved ejection fraction (HFpEF) has been elucidated to date. The purpose of this ongoing study is to elucidate the pathophysiology and prognostic factors for patients with HFpEF admitted to participating institutes. We also aim to obtain insights into the development of new diagnostic and treatment methods by analysing patient background factors, clinical data and follow-up information. Methods and analysis This study is a prospective, multicentre, observational study of patients aged ≥20 years admitted due to acute decompensated heart failure with preserved left ventricular ejection fraction (≥50%) and elevated N-terminal-pro brain natriuretic peptide (NT-proBNP) (≥400 pg/mL). The study began in June 2016, with the participation of Osaka University Hospital and 31 affiliated facilities. We will collect data on history in detail, accompanying diseases, quality of life, frailty score, medication history, and laboratory and echocardiographic data. We will follow-up each patient for 5 years, and collect outcome data on mortality, cause of death, and the number and cause of hospitalisation. The target number of registered cases is 1500 cases in 5 years. Ethics and dissemination The protocol was approved by the Institutional Review Board (IRB) of Osaka University Hospital on 24 February 2016 (ID: 15471), and by the IRBs of the all participating facilities. The findings will be disseminated through peer-reviewed publications and conference presentations.
DC.rights	© 2020 Author(s) (or their employer(s)). This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
DC.format	78366
citation_title	Study protocol for the PURSUIT-HFpEF study: A Prospective, Multicenter, Observational Study of Patients with Heart Failure with Preserved Ejection Fraction
citation_author	Suna, Shinichiro
	Hikoso, Shungo
	Yamada, Takahisa
	Uematsu, Masaaki
	Yasumura, Yoshio
	Nakagawa, Akito
	Takeda, Toshihiro
	Kojima, Takayuki
	Kida, Hirota
	Oeun, Bolrathanak
	Sunaga, Akihiro
	Kitamura, Tetsuhisa
	Dohi, Tomoharu
	Okada, Katsuki
	Mizuno, Hiroya
	Nakatani, Daisaku
	Iso, Hiroyasu
	Matsumura, Yasushi
	Sakata, Yasushi
citation_publisher	BMJ Publishing Group
citation_language	English
citation_date	2020-10-15
citation_journal_title	BMJ Open
citation_volume	10
citation_issue	10
citation_firstpage	e038294
citation_doi	https://doi.org/10.1136/bmjopen-2020-038294
citation_pmid	33060085
citation_public_url	https://hdl.handle.net/11094/78366

Study protocol for the PURSUIT-HFpEF study: A Prospective, Multicenter, Observational Study of Patients with Heart Failure with Preserved Ejection Fraction

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