Dietary acrylamide intake and the risk of liver cancer: The japan public health center-based prospective study

Zha, Ling; Sobue, Tomotaka; Kitamura, Tetsuhisa; Kitamura, Yuri; Ishihara, Junko; Kotemori, Ayaka; Liu, Rong; Ikeda, Sayaka; Sawada, Norie; Iwasaki, Motoki; Tsugane, Shoichiro

doi:https://doi.org/10.3390/nu12092503

Dietary acrylamide intake and the risk of liver cancer: The japan public health center-based prospective study

Zha, Ling; Sobue, Tomotaka; Kitamura, Tetsuhisa et al.

Nutrients, 2020, 12(9), 2503

Number of Access:1,331（2025-10-21 07:47 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/78367

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Title	Dietary acrylamide intake and the risk of liver cancer: The japan public health center-based prospective study
Creator	NRID 1000040895398 1000040895398 researchmap permalink lingzha lingzha Scopus Author ID 57193822882 57193822882 CreatorName Zha, Ling
	NRID 1000050270674 1000050270674 researchmap permalink read_0159567 read_0159567 Scopus Author ID 7005649935 7005649935 CreatorName Sobue, Tomotaka
	NRID 1000030639810 1000030639810 ORCID 0000-0003-0107-0580 0000-0003-0107-0580 researchmap permalink Kitamura_T Kitamura_T Scopus Author ID 22234282700 22234282700 CreatorName Kitamura, Tetsuhisa
	NRID 1000090294074 1000090294074 CreatorName Kitamura, Yuri
	NRID 1000030415509 1000030415509 CreatorName Ishihara, Junko
	NRID 1000070701233 1000070701233 CreatorName Kotemori, Ayaka
	CreatorName Liu, Rong
	CreatorName Ikeda, Sayaka
	NRID 1000000446551 1000000446551 CreatorName Sawada, Norie
	NRID 1000060392338 1000060392338 CreatorName Iwasaki, Motoki
	NRID 1000040179982 1000040179982 CreatorName Tsugane, Shoichiro
Subject	Acrylamide
	Cohort
	Diet
	Liver cancer
Description	Zha, L.; Sobue, T.; Kitamura, T.; Kitamura, Y.; Ishihara, J.; Kotemori, A.; Liu, R.; Ikeda, S.; Sawada, N.; Iwasaki, M.; Tsugane, S.; JPHC Study Group, f.t. Dietary Acrylamide Intake and the Risk of Liver Cancer: The Japan Public Health Center-Based Prospective Study. Nutrients 2020, 12, 2503. https://doi.org/10.3390/nu12092503
Abstract	Acrylamide has been studied for its carcinogenicity in experimental animals, causing tumors at several organ sites, and has been considered probably carcinogenic to humans as well. Given the small number of epidemiological studies that have been conducted, it is still uncertain whether the consumption of acrylamide is associated with liver cancer. Therefore, we investigated a study to determine the possible relationship between acrylamide intake and the risk of developing liver cancer in the Japanese population. A total of 85,305 participants, from the Japan Public Health Center-based Prospective Study, who provided a validated food-frequency questionnaire were enrolled between 1995 and 1998. During a median of 16.0 years follow-up, 744 new liver cancer cases were identified. Compared to the lowest tertile of acrylamide consumption (<4.8 μg/day), the multivariate hazard ratio (HR) for the highest tertile (≥7.6 μg/day) was 0.79 (95% confidence interval [CI] = 0.65-0.95) for liver cancer using multivariable model 1, adjusted for smoking status, body mass index (BMI), physical activity, medical history, and alcohol consumption; whereas the inverse relationship disappeared after additionally adjusting for coffee consumption in multivariable model 2 with HR of 1.08 (95% CI = 0.87-1.34) for the highest tertile. The effect of dietary acrylamide intake on the risk of liver cancer was not observed in the Japanese population.
Publisher	MDPI
Source Title	Nutrients
Volume (Issue)	12(9)
Page	2503
Date of Issued	2020-08-19
Language	English
Handle URL	https://hdl.handle.net/11094/78367
eISSN	20726643
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.3390/nu12092503
Relation.isIdenticalTo	PMID 32825036
Access Rights	open access
CopyRight	© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is licensed under a Creative Commons Attribution 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCMI Type	Text
DCTERMS.bibliographicCitation	Nutrients. 2020, 12(9), p. 2503
DC.title	Dietary acrylamide intake and the risk of liver cancer: The japan public health center-based prospective study
DC.creator	Zha, Ling
	Sobue, Tomotaka
	Kitamura, Tetsuhisa
	Kitamura, Yuri
	Ishihara, Junko
	Kotemori, Ayaka
	Liu, Rong
	Ikeda, Sayaka
	Sawada, Norie
	Iwasaki, Motoki
	Tsugane, Shoichiro
DC.publisher	MDPI
DC.language' scheme='DCTERMS.RFC1766	English
DC.type' scheme='DCTERMS.DCMIType	Text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2020-08-19
DC.identifier	https://doi.org/10.3390/nu12092503
DC.subject	Acrylamide
	Cohort
	Diet
	Liver cancer
DC.description	Zha, L.; Sobue, T.; Kitamura, T.; Kitamura, Y.; Ishihara, J.; Kotemori, A.; Liu, R.; Ikeda, S.; Sawada, N.; Iwasaki, M.; Tsugane, S.; JPHC Study Group, f.t. Dietary Acrylamide Intake and the Risk of Liver Cancer: The Japan Public Health Center-Based Prospective Study. Nutrients 2020, 12, 2503. https://doi.org/10.3390/nu12092503
DCTERMS.abstract	Acrylamide has been studied for its carcinogenicity in experimental animals, causing tumors at several organ sites, and has been considered probably carcinogenic to humans as well. Given the small number of epidemiological studies that have been conducted, it is still uncertain whether the consumption of acrylamide is associated with liver cancer. Therefore, we investigated a study to determine the possible relationship between acrylamide intake and the risk of developing liver cancer in the Japanese population. A total of 85,305 participants, from the Japan Public Health Center-based Prospective Study, who provided a validated food-frequency questionnaire were enrolled between 1995 and 1998. During a median of 16.0 years follow-up, 744 new liver cancer cases were identified. Compared to the lowest tertile of acrylamide consumption (<4.8 μg/day), the multivariate hazard ratio (HR) for the highest tertile (≥7.6 μg/day) was 0.79 (95% confidence interval [CI] = 0.65-0.95) for liver cancer using multivariable model 1, adjusted for smoking status, body mass index (BMI), physical activity, medical history, and alcohol consumption; whereas the inverse relationship disappeared after additionally adjusting for coffee consumption in multivariable model 2 with HR of 1.08 (95% CI = 0.87-1.34) for the highest tertile. The effect of dietary acrylamide intake on the risk of liver cancer was not observed in the Japanese population.
DC.rights	© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	78367
citation_title	Dietary acrylamide intake and the risk of liver cancer: The japan public health center-based prospective study
citation_author	Zha, Ling
	Sobue, Tomotaka
	Kitamura, Tetsuhisa
	Kitamura, Yuri
	Ishihara, Junko
	Kotemori, Ayaka
	Liu, Rong
	Ikeda, Sayaka
	Sawada, Norie
	Iwasaki, Motoki
	Tsugane, Shoichiro
citation_publisher	MDPI
citation_language	English
citation_date	2020-08-19
citation_journal_title	Nutrients
citation_volume	12
citation_issue	9
citation_firstpage	2503
citation_doi	https://doi.org/10.3390/nu12092503
citation_pmid	32825036
citation_public_url	https://hdl.handle.net/11094/78367

Dietary acrylamide intake and the risk of liver cancer: The japan public health center-based prospective study

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