Dietary acrylamide intake and risk of lung cancer: The Japan public health center based prospective study

Liu, Rong; Zha, Ling; Sobue, Tomotaka; Kitamura, Tetsuhisa; Ishihara, Junko; Kotemori, Ayaka; Ikeda, Sayaka; Sawada, Norie; Iwasaki, Motoki; Tsugane, Shoichiro

doi:https://doi.org/10.3390/nu12082417

Dietary acrylamide intake and risk of lung cancer: The Japan public health center based prospective study

Liu, Rong; Zha, Ling; Sobue, Tomotaka et al.

Nutrients, 2020, 12(8), 2417

Number of Access:426（2025-06-10 13:14 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/78370

Link to primary information

File	Format	Terms of use	Size	Views	Date.Available	Description	information
Nutrients_12_08_2417	pdf	None	578 KB	115	2021.02.02

Creative Commons : Attribution

Item Information

Output File Export EndNote Basic Export Mendeley

Title	Dietary acrylamide intake and risk of lung cancer: The Japan public health center based prospective study
Creator	CreatorName Liu, Rong
	NRID 1000040895398 1000040895398 researchmap permalink lingzha lingzha Scopus Author ID 57193822882 57193822882 CreatorName Zha, Ling
	NRID 1000050270674 1000050270674 researchmap permalink read_0159567 read_0159567 Scopus Author ID 7005649935 7005649935 CreatorName Sobue, Tomotaka
	NRID 1000030639810 1000030639810 ORCID 0000-0003-0107-0580 0000-0003-0107-0580 researchmap permalink Kitamura_T Kitamura_T Scopus Author ID 22234282700 22234282700 CreatorName Kitamura, Tetsuhisa
	NRID 1000030415509 1000030415509 CreatorName Ishihara, Junko
	NRID 1000070701233 1000070701233 CreatorName Kotemori, Ayaka
	CreatorName Ikeda, Sayaka
	NRID 1000000446551 1000000446551 CreatorName Sawada, Norie
	NRID 1000060392338 1000060392338 CreatorName Iwasaki, Motoki
	NRID 1000040179982 1000040179982 CreatorName Tsugane, Shoichiro
Subject	Cohort
	Dietary acrylamide
	Japan
	Lung cancer
Description	Liu, R.; Zha, L.; Sobue, T.; Kitamura, T.; Ishihara, J.; Kotemori, A.; Ikeda, S.; Sawada, N.; Iwasaki, M.; Tsugane, S. Dietary Acrylamide Intake and Risk of Lung Cancer: The Japan Public Health Center Based Prospective Study. Nutrients 2020, 12, 2417. https://doi.org/10.3390/nu12082417
Abstract	Acrylamide, which forms in heat-treated foods with high carbohydrate content, is a probable human carcinogen. This study aimed to evaluate the association between dietary acrylamide intake and lung cancer using data from the Japan Public Health Center based Prospective Study. Our study included 85,303 participants who completed a food frequency questionnaire. Cox proportional hazards regression models were used to assess hazard ratios and 95% confidence intervals (CIs) after adjusting for confounders. After 14.3 years and 15.4 years of mean follow-up period, 1187 and 485 lung cancer cases were identified in men and women, respectively. The multivariable-adjusted hazard ratios of 10-μg/day increment in acrylamide intake were 1.01 (95% CI, 0.99-1.02) in men and 0.98 (95% CI, 0.95-1.02) in women. Compared with the lowest quartile of acrylamide intake, the hazard ratios for the highest quartile were 1.13 (95% CI, 0.95-1.33; p for trend = 0.12) in men and 1.03 (95% CI, 0.78-1.36; p for trend = 0.86) in women in the multivariable-adjusted model. Moreover, there was also no significant association observed in the stratified analysis for histological subtypes of lung cancer. This study demonstrated that dietary acrylamide intake was not associated with increased lung cancer risk in the Japanese population.
Publisher	MDPI
Source Title	Nutrients
Volume (Issue)	12(8)
Page	2417
Date of Issued	2020-08-12
Language	English
Handle URL	https://hdl.handle.net/11094/78370
eISSN	20726643
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.3390/nu12082417
Relation.isIdenticalTo	PMID 32806637
Access Rights	open access
CopyRight	© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is licensed under a Creative Commons Attribution 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCMI Type	Text
DCTERMS.bibliographicCitation	Nutrients. 2020, 12(8), p. 2417
DC.title	Dietary acrylamide intake and risk of lung cancer: The Japan public health center based prospective study
DC.creator	Liu, Rong
	Zha, Ling
	Sobue, Tomotaka
	Kitamura, Tetsuhisa
	Ishihara, Junko
	Kotemori, Ayaka
	Ikeda, Sayaka
	Sawada, Norie
	Iwasaki, Motoki
	Tsugane, Shoichiro
DC.publisher	MDPI
DC.language' scheme='DCTERMS.RFC1766	English
DC.type' scheme='DCTERMS.DCMIType	Text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2020-08-12
DC.identifier	https://doi.org/10.3390/nu12082417
DC.subject	Cohort
	Dietary acrylamide
	Japan
	Lung cancer
DC.description	Liu, R.; Zha, L.; Sobue, T.; Kitamura, T.; Ishihara, J.; Kotemori, A.; Ikeda, S.; Sawada, N.; Iwasaki, M.; Tsugane, S. Dietary Acrylamide Intake and Risk of Lung Cancer: The Japan Public Health Center Based Prospective Study. Nutrients 2020, 12, 2417. https://doi.org/10.3390/nu12082417
DCTERMS.abstract	Acrylamide, which forms in heat-treated foods with high carbohydrate content, is a probable human carcinogen. This study aimed to evaluate the association between dietary acrylamide intake and lung cancer using data from the Japan Public Health Center based Prospective Study. Our study included 85,303 participants who completed a food frequency questionnaire. Cox proportional hazards regression models were used to assess hazard ratios and 95% confidence intervals (CIs) after adjusting for confounders. After 14.3 years and 15.4 years of mean follow-up period, 1187 and 485 lung cancer cases were identified in men and women, respectively. The multivariable-adjusted hazard ratios of 10-μg/day increment in acrylamide intake were 1.01 (95% CI, 0.99-1.02) in men and 0.98 (95% CI, 0.95-1.02) in women. Compared with the lowest quartile of acrylamide intake, the hazard ratios for the highest quartile were 1.13 (95% CI, 0.95-1.33; p for trend = 0.12) in men and 1.03 (95% CI, 0.78-1.36; p for trend = 0.86) in women in the multivariable-adjusted model. Moreover, there was also no significant association observed in the stratified analysis for histological subtypes of lung cancer. This study demonstrated that dietary acrylamide intake was not associated with increased lung cancer risk in the Japanese population.
DC.rights	© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	78370
citation_title	Dietary acrylamide intake and risk of lung cancer: The Japan public health center based prospective study
citation_author	Liu, Rong
	Zha, Ling
	Sobue, Tomotaka
	Kitamura, Tetsuhisa
	Ishihara, Junko
	Kotemori, Ayaka
	Ikeda, Sayaka
	Sawada, Norie
	Iwasaki, Motoki
	Tsugane, Shoichiro
citation_publisher	MDPI
citation_language	English
citation_date	2020-08-12
citation_journal_title	Nutrients
citation_volume	12
citation_issue	8
citation_firstpage	2417
citation_doi	https://doi.org/10.3390/nu12082417
citation_pmid	32806637
citation_public_url	https://hdl.handle.net/11094/78370

Dietary acrylamide intake and risk of lung cancer: The Japan public health center based prospective study

Link to primary information

Item Information

Show details