Smoking, alcohol consumption, and risks for biliary tract cancer and intrahepatic bile duct cancer

Makiuchi, Takeshi; Sobue, Tomotaka; Kitamura, Tetsuhisa; Sawada, Norie; Iwasaki, Motoki; Yamaji, Taiki; Shimazu, Taichi; Inoue, Manami; Tsugane, Shoichiro

doi:https://doi.org/10.2188/jea.JE20180011

Smoking, alcohol consumption, and risks for biliary tract cancer and intrahepatic bile duct cancer

Makiuchi, Takeshi; Sobue, Tomotaka; Kitamura, Tetsuhisa et al.

Journal of Epidemiology, 2019, 29(5), 180-186

Number of Access:1,047（2025-10-21 12:17 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/78390

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Title	Smoking, alcohol consumption, and risks for biliary tract cancer and intrahepatic bile duct cancer
Creator	CreatorName Makiuchi, Takeshi
	NRID 1000050270674 1000050270674 researchmap permalink read_0159567 read_0159567 Scopus Author ID 7005649935 7005649935 CreatorName Sobue, Tomotaka
	NRID 1000030639810 1000030639810 ORCID 0000-0003-0107-0580 0000-0003-0107-0580 researchmap permalink Kitamura_T Kitamura_T Scopus Author ID 22234282700 22234282700 CreatorName Kitamura, Tetsuhisa
	NRID 1000000446551 1000000446551 CreatorName Sawada, Norie
	NRID 1000060392338 1000060392338 CreatorName Iwasaki, Motoki
	NRID 1000010466203 1000010466203 CreatorName Yamaji, Taiki
	NRID 1000000466202 1000000466202 CreatorName Shimazu, Taichi
	NRID 1000070250248 1000070250248 CreatorName Inoue, Manami
	NRID 1000040179982 1000040179982 CreatorName Tsugane, Shoichiro
Description	Takeshi Makiuchi, Tomotaka Sobue, Tetsuhisa Kitamura, Norie Sawada, Motoki Iwasaki, Taiki Yamaji, Taichi Shimazu, Manami Inoue, Shoichiro Tsugane, Smoking, Alcohol Consumption, and Risks for Biliary Tract Cancer and Intrahepatic Bile Duct Cancer, Journal of Epidemiology, 2019, Volume 29, Issue 5, Pages 180-186, Released May 05, 2019, [Advance publication] Released May 11, 2018, Online ISSN 1349-9092, Print ISSN 0917-5040, https://doi.org/10.2188/jea.JE20180011, https://www.jstage.jst.go.jp/article/jea/29/5/29_JE20180011/_article/-char/en
Abstract	Background: Smoking and alcohol are established risk factors for several types of cancer, but the effects on biliary cancers, comprising biliary tract cancer (BTC) and intrahepatic bile duct cancer (IHBDC), have been inconclusive. Methods: In this population-based prospective cohort study in Japan, we investigated the association of smoking and alcohol consumption with the risks of BTC and its subtypes and IHBDC incidence in men and women. Furthermore, the association of smoking stratified by drinking status was investigated. The hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated using the Cox proportional hazard model. Results: A total of 48,367 men and 54,776 women aged 40-69 years were enrolled from 1990 through 1994 and followed up for 846,417 person-years in men and 1,021,330 person-years in women until 2012, during which 246 BTC and 80 IHBDC male cases and 227 BTC and 60 IHBDC female cases were identified. In men, smoking was significantly associated with an increased risk of IHBDC (HR 2.25; 95% CI, 1.19-4.25 for current smokers with ≥30 pack-years compared with non-smokers), and the risk was enhanced among regular drinkers compared with non=occasional-drinkers (HR 3.48; 95% CI, 1.41-8.61). A nonsignificant increase of IHBDC risk associated with alcohol was observed. Neither smoking nor alcohol consumption was associated with BTC risk. In women, the association of smoking and alcohol consumption with IHBDC and BTC was unclear because current smokers and regular drinkers were very few. Conclusion: Our findings suggest that smoking increases IHBDC risk in men, especially among regular drinkers.
Publisher	Japan Epidemiology Association
Source Title	Journal of Epidemiology
Volume (Issue)	29(5)
Page	180-186
Date of Issued	2019-05-05
Language	English
Handle URL	https://hdl.handle.net/11094/78390
PISSN	09175040
eISSN	13499092
NCID	AA1201887X
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.2188/jea.JE20180011
Relation.isIdenticalTo	PMID 29760302
Access Rights	open access
CopyRight	© 2018 Takeshi Makiuchi et al. This article is licensed under a Creative Commons Attribution 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCMI Type	Text
DCTERMS.bibliographicCitation	Journal of Epidemiology. 2019, 29(5), p. 180-186
DC.title	Smoking, alcohol consumption, and risks for biliary tract cancer and intrahepatic bile duct cancer
DC.creator	Makiuchi, Takeshi
	Sobue, Tomotaka
	Kitamura, Tetsuhisa
	Sawada, Norie
	Iwasaki, Motoki
	Yamaji, Taiki
	Shimazu, Taichi
	Inoue, Manami
	Tsugane, Shoichiro
DC.publisher	Japan Epidemiology Association
DC.language' scheme='DCTERMS.RFC1766	English
DC.type' scheme='DCTERMS.DCMIType	Text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2019-05-05
DC.identifier	https://doi.org/10.2188/jea.JE20180011
DC.description	Takeshi Makiuchi, Tomotaka Sobue, Tetsuhisa Kitamura, Norie Sawada, Motoki Iwasaki, Taiki Yamaji, Taichi Shimazu, Manami Inoue, Shoichiro Tsugane, Smoking, Alcohol Consumption, and Risks for Biliary Tract Cancer and Intrahepatic Bile Duct Cancer, Journal of Epidemiology, 2019, Volume 29, Issue 5, Pages 180-186, Released May 05, 2019, [Advance publication] Released May 11, 2018, Online ISSN 1349-9092, Print ISSN 0917-5040, https://doi.org/10.2188/jea.JE20180011, https://www.jstage.jst.go.jp/article/jea/29/5/29_JE20180011/_article/-char/en
DCTERMS.abstract	Background: Smoking and alcohol are established risk factors for several types of cancer, but the effects on biliary cancers, comprising biliary tract cancer (BTC) and intrahepatic bile duct cancer (IHBDC), have been inconclusive. Methods: In this population-based prospective cohort study in Japan, we investigated the association of smoking and alcohol consumption with the risks of BTC and its subtypes and IHBDC incidence in men and women. Furthermore, the association of smoking stratified by drinking status was investigated. The hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated using the Cox proportional hazard model. Results: A total of 48,367 men and 54,776 women aged 40-69 years were enrolled from 1990 through 1994 and followed up for 846,417 person-years in men and 1,021,330 person-years in women until 2012, during which 246 BTC and 80 IHBDC male cases and 227 BTC and 60 IHBDC female cases were identified. In men, smoking was significantly associated with an increased risk of IHBDC (HR 2.25; 95% CI, 1.19-4.25 for current smokers with ≥30 pack-years compared with non-smokers), and the risk was enhanced among regular drinkers compared with non=occasional-drinkers (HR 3.48; 95% CI, 1.41-8.61). A nonsignificant increase of IHBDC risk associated with alcohol was observed. Neither smoking nor alcohol consumption was associated with BTC risk. In women, the association of smoking and alcohol consumption with IHBDC and BTC was unclear because current smokers and regular drinkers were very few. Conclusion: Our findings suggest that smoking increases IHBDC risk in men, especially among regular drinkers.
DC.rights	© 2018 Takeshi Makiuchi et al. This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	78390
citation_title	Smoking, alcohol consumption, and risks for biliary tract cancer and intrahepatic bile duct cancer
citation_author	Makiuchi, Takeshi
	Sobue, Tomotaka
	Kitamura, Tetsuhisa
	Sawada, Norie
	Iwasaki, Motoki
	Yamaji, Taiki
	Shimazu, Taichi
	Inoue, Manami
	Tsugane, Shoichiro
citation_publisher	Japan Epidemiology Association
citation_language	English
citation_date	2019-05-05
citation_journal_title	Journal of Epidemiology
citation_volume	29
citation_issue	5
citation_firstpage	180
citation_lastpage	186
citation_doi	https://doi.org/10.2188/jea.JE20180011
citation_pmid	29760302
citation_public_url	https://hdl.handle.net/11094/78390

Smoking, alcohol consumption, and risks for biliary tract cancer and intrahepatic bile duct cancer

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