Reduced risk of recurrent myocardial infarction in homozygous carriers of the chromosome 9p21 rs1333049 c risk allele in the contemporary percutaneous coronary intervention era: A prospective observational study

Hara, Masahiko; Sakata, Yasuhiko; Nakatani, Daisaku; Suna, Shinichiro; Usami, Masaya; Matsumoto, Sen; Ozaki, Kouichi; Nishino, Masami; Sato, Hiroshi; Kitamura, Tetsuhisa; Nanto, Shinsuke; Hamasaki, Toshimitsu; Tanaka, Toshihiro; Hori, Masatsugu; Komuro, Issei

doi:https://doi.org/10.1136/bmjopen-2014-005438

Reduced risk of recurrent myocardial infarction in homozygous carriers of the chromosome 9p21 rs1333049 c risk allele in the contemporary percutaneous coronary intervention era: A prospective observational study

Hara, Masahiko; Sakata, Yasuhiko; Nakatani, Daisaku et al.

BMJ Open, 2014, 4(8), e005438

Number of Access:1,486（2025-12-11 21:34 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/78414

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Title	Reduced risk of recurrent myocardial infarction in homozygous carriers of the chromosome 9p21 rs1333049 c risk allele in the contemporary percutaneous coronary intervention era: A prospective observational study
Creator	CreatorName Hara, Masahiko
	NRID 1000090379206 1000090379206 CreatorName Sakata, Yasuhiko
	NRID 1000060444535 1000060444535 researchmap permalink dsyma dsyma Scopus Author ID 6603545219 6603545219 ORCID 0000-0002-1534-2033 0000-0002-1534-2033 CreatorName Nakatani, Daisaku
	NRID 1000040573085 1000040573085 CreatorName Suna, Shinichiro
	CreatorName Usami, Masaya
	CreatorName Matsumoto, Sen
	CreatorName Ozaki, Kouichi
	CreatorName Nishino, Masami
	NRID 1000010294092 1000010294092 CreatorName Sato, Hiroshi
	NRID 1000030639810 1000030639810 ORCID 0000-0003-0107-0580 0000-0003-0107-0580 researchmap permalink Kitamura_T Kitamura_T Scopus Author ID 22234282700 22234282700 CreatorName Kitamura, Tetsuhisa
	CreatorName Nanto, Shinsuke
	NRID 1000040379243 1000040379243 CreatorName Hamasaki, Toshimitsu
	NRID 1000050292850 1000050292850 CreatorName Tanaka, Toshihiro
	CreatorName Hori, Masatsugu
	NRID 1000030260483 1000030260483 CreatorName Komuro, Issei
Description	Hara M, Sakata Y, Nakatani D on behalf of the OACIS Investigators, et al. Reduced risk of recurrent myocardial infarction in homozygous carriers of the chromosome 9p21 rs1333049 C risk allele in the contemporary percutaneous coronary intervention era: a prospective observational study. BMJ Open 2014;4:e005438. doi: 10.1136/bmjopen-2014-005438
Abstract	Objectives: Chromosome 9p21 single nucleotide polymorphism (SNP) is a susceptibility variant for acute myocardial infarction (AMI) in the primary prevention setting. However, it is controversial whether this SNP is also associated with recurrent myocardial infarction (ReMI) in the secondary prevention setting. The purpose of this study is to evaluate the impact of chromosome 9p21 SNP on ReMI in patients receiving secondary prevention programmes after AMI. Design: A prospective observational study. Setting: Osaka Acute Coronary Insufficiency Study (OACIS) in Japan. Participants: 2022 patients from the OACIS database. Interventions: Genotyping of the 9p21 rs1333049 variant. Primary outcome measures: ReMI event after survival discharge for 1 year. Results: A total of 43 ReMI occurred during the 1 year follow-up period. Although the rs1333049 C allele had an increased susceptibility to their first AMI in an additive model when compared with 1373 healthy controls (OR 1.20, 95% CI 1.09 to 1.33, p=2.3*10-4), patients with the CC genotype had a lower incidence of ReMI at 1 year after discharge of AMI (log-rank p=0.005). The adjusted HR of the CC genotype as compared with the CG/GG genotypes was 0.20 (0.06 to 0.65, p=0.007). Subgroup analysis demonstrated that the association between the rs1333049 CC genotype and a lower incidence of 1 year ReMI was common to all subgroups. Conclusions: Homozygous carriers of the rs1333049 C allele on chromosome 9p21 showed a reduced risk of 1 year ReMI in the contemporary percutaneous coronary intervention era, although the C allele had conferred susceptibility to their first AMI.
Publisher	BMJ Publishing Group
Source Title	BMJ Open
Volume (Issue)	4(8)
Page	e005438
Date of Issued	2014-08-13
Language	English
Handle URL	https://hdl.handle.net/11094/78414
eISSN	20446055
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1136/bmjopen-2014-005438
Relation.isIdenticalTo	PMID 25232560
Access Rights	open access
CopyRight	© 2014 BMJ Publishing Group Ltd. This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCMI Type	Text
DCTERMS.bibliographicCitation	BMJ Open. 2014, 4(8), p. e005438
DC.title	Reduced risk of recurrent myocardial infarction in homozygous carriers of the chromosome 9p21 rs1333049 c risk allele in the contemporary percutaneous coronary intervention era: A prospective observational study
DC.creator	Hara, Masahiko
	Sakata, Yasuhiko
	Nakatani, Daisaku
	Suna, Shinichiro
	Usami, Masaya
	Matsumoto, Sen
	Ozaki, Kouichi
	Nishino, Masami
	Sato, Hiroshi
	Kitamura, Tetsuhisa
	Nanto, Shinsuke
	Hamasaki, Toshimitsu
	Tanaka, Toshihiro
	Hori, Masatsugu
	Komuro, Issei
DC.publisher	BMJ Publishing Group
DC.language' scheme='DCTERMS.RFC1766	English
DC.type' scheme='DCTERMS.DCMIType	Text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2014-08-13
DC.identifier	https://doi.org/10.1136/bmjopen-2014-005438
DC.description	Hara M, Sakata Y, Nakatani D on behalf of the OACIS Investigators, et al. Reduced risk of recurrent myocardial infarction in homozygous carriers of the chromosome 9p21 rs1333049 C risk allele in the contemporary percutaneous coronary intervention era: a prospective observational study. BMJ Open 2014;4:e005438. doi: 10.1136/bmjopen-2014-005438
DCTERMS.abstract	Objectives: Chromosome 9p21 single nucleotide polymorphism (SNP) is a susceptibility variant for acute myocardial infarction (AMI) in the primary prevention setting. However, it is controversial whether this SNP is also associated with recurrent myocardial infarction (ReMI) in the secondary prevention setting. The purpose of this study is to evaluate the impact of chromosome 9p21 SNP on ReMI in patients receiving secondary prevention programmes after AMI. Design: A prospective observational study. Setting: Osaka Acute Coronary Insufficiency Study (OACIS) in Japan. Participants: 2022 patients from the OACIS database. Interventions: Genotyping of the 9p21 rs1333049 variant. Primary outcome measures: ReMI event after survival discharge for 1 year. Results: A total of 43 ReMI occurred during the 1 year follow-up period. Although the rs1333049 C allele had an increased susceptibility to their first AMI in an additive model when compared with 1373 healthy controls (OR 1.20, 95% CI 1.09 to 1.33, p=2.3*10-4), patients with the CC genotype had a lower incidence of ReMI at 1 year after discharge of AMI (log-rank p=0.005). The adjusted HR of the CC genotype as compared with the CG/GG genotypes was 0.20 (0.06 to 0.65, p=0.007). Subgroup analysis demonstrated that the association between the rs1333049 CC genotype and a lower incidence of 1 year ReMI was common to all subgroups. Conclusions: Homozygous carriers of the rs1333049 C allele on chromosome 9p21 showed a reduced risk of 1 year ReMI in the contemporary percutaneous coronary intervention era, although the C allele had conferred susceptibility to their first AMI.
DC.rights	© 2014 BMJ Publishing Group Ltd. This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
DC.format	78414
citation_title	Reduced risk of recurrent myocardial infarction in homozygous carriers of the chromosome 9p21 rs1333049 c risk allele in the contemporary percutaneous coronary intervention era: A prospective observational study
citation_author	Hara, Masahiko
	Sakata, Yasuhiko
	Nakatani, Daisaku
	Suna, Shinichiro
	Usami, Masaya
	Matsumoto, Sen
	Ozaki, Kouichi
	Nishino, Masami
	Sato, Hiroshi
	Kitamura, Tetsuhisa
	Nanto, Shinsuke
	Hamasaki, Toshimitsu
	Tanaka, Toshihiro
	Hori, Masatsugu
	Komuro, Issei
citation_publisher	BMJ Publishing Group
citation_language	English
citation_date	2014-08-13
citation_journal_title	BMJ Open
citation_volume	4
citation_issue	8
citation_firstpage	e005438
citation_doi	https://doi.org/10.1136/bmjopen-2014-005438
citation_pmid	25232560
citation_public_url	https://hdl.handle.net/11094/78414

Reduced risk of recurrent myocardial infarction in homozygous carriers of the chromosome 9p21 rs1333049 c risk allele in the contemporary percutaneous coronary intervention era: A prospective observational study

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