Association of lifestyle-related factors with circadian onset patterns of acute myocardial infarction: A prospective observational study in Japan

Edahiro, Ryuya; Sakata, Yasuhiko; Nakatani, Daisaku; Suna, Shinichiro; Usami, Masaya; Matsumoto, Sen; Hara, Masahiko; Kitamura, Tetsuhisa; Sato, Hiroshi; Yamashita, Shizuya; Nanto, Shinsuke; Hikoso, Shungo; Sakata, Yasushi; Hori, Masatsugu; Hamasaki, Toshimitsu; Komuro, Issei

doi:https://doi.org/10.1136/bmjopen-2014-005067

Association of lifestyle-related factors with circadian onset patterns of acute myocardial infarction: A prospective observational study in Japan

Edahiro, Ryuya; Sakata, Yasuhiko; Nakatani, Daisaku et al.

BMJ Open, 2014, 4(6), e005067

Number of Access:351（2025-04-30 16:03 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/78415

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Title	Association of lifestyle-related factors with circadian onset patterns of acute myocardial infarction: A prospective observational study in Japan
Creator	CreatorName Edahiro, Ryuya
	NRID 1000090379206 1000090379206 CreatorName Sakata, Yasuhiko
	NRID 1000060444535 1000060444535 researchmap permalink dsyma dsyma Scopus Author ID 6603545219 6603545219 CreatorName Nakatani, Daisaku
	NRID 1000040573085 1000040573085 CreatorName Suna, Shinichiro
	CreatorName Usami, Masaya
	CreatorName Matsumoto, Sen
	CreatorName Hara, Masahiko
	NRID 1000030639810 1000030639810 ORCID 0000-0003-0107-0580 0000-0003-0107-0580 researchmap permalink Kitamura_T Kitamura_T Scopus Author ID 22234282700 22234282700 CreatorName Kitamura, Tetsuhisa
	NRID 1000010294092 1000010294092 CreatorName Sato, Hiroshi
	NRID 1000060243242 1000060243242 CreatorName Yamashita, Shizuya
	CreatorName Nanto, Shinsuke
	NRID 1000030423164 1000030423164 researchmap permalink hikoso_osakauniv hikoso_osakauniv Scopus Author ID 6507288830 6507288830 CreatorName Hikoso, Shungo
	NRID 1000000397671 1000000397671 ORCID 0000-0002-5618-4721 0000-0002-5618-4721 researchmap permalink C4589 C4589 Scopus Author ID 35395964700 35395964700 CreatorName Sakata, Yasushi
	CreatorName Hori, Masatsugu
	NRID 1000040379243 1000040379243 CreatorName Hamasaki, Toshimitsu
	NRID 1000030260483 1000030260483 CreatorName Komuro, Issei
Description	Edahiro R, Sakata Y, Nakatani D, et al. Association of lifestyle-related factors with circadian onset patterns of acute myocardial infarction: a prospective observational study in Japan. BMJ Open 2014;4:e005067. doi: 10.1136/bmjopen-2014-005067
Abstract	Objective: The onset of acute myocardial infarction (AMI) shows characteristic circadian variations involving a definite morning peak and a less-defined night-time peak. However, the factors influencing the circadian patterns of AMI onset and their influence on morning and night-time peaks have not been fully elucidated. Design, setting and participants: An analysis of patients registered between 1998 and 2008 in the Osaka Acute Coronary Insufficiency Study, which is a prospective, multicentre observational study of patients with AMI in the Osaka region of Japan. The present study included 7755 consecutive patients with a known time of AMI onset. Main outcomes and measures: A mixture of two von Mises distributions was used to examine whether a circadian pattern of AMI had uniform, unimodal or bimodal distribution, and the likelihood ratio test was then used to select the best circadian pattern among them. The hierarchical likelihood ratio test was used to identify factors affecting the circadian patterns of AMI onset. The Kaplan-Meier method was used to estimate survival curves of 1-year mortality according to AMI onset time. Results: The overall population had a bimodal circadian pattern of AMI onset characterised by a high and sharp morning peak and a lower and less-defined night-time peak (bimodal p<0.001). Although several lifestyle-related factors had a statistically significant association with the circadian patterns of AMI onset, serum triglyceride levels had the most prominent association with the circadian patterns of AMI onset. Patients with triglyceride ?150 mg/dL on admission had only one morning peak in the circadian pattern of AMI onset during weekdays, with no peaks detected on weekends, whereas all other subgroups had two peaks throughout the week. Conclusions: The circadian pattern of AMI onset was characterised by bimodality. Notably, several lifestyle-related factors, particularly serum triglyceride levels, had a strong relation with the circadian pattern of AMI onset.
Publisher	BMJ Publishing Group
Source Title	BMJ Open
Volume (Issue)	4(6)
Page	e005067
Date of Issued	2014-06-06
Language	English
Handle URL	https://hdl.handle.net/11094/78415
eISSN	20446055
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1136/bmjopen-2014-005067
Relation.isIdenticalTo	PMID 24907246
Access Rights	open access
CopyRight	© 2014 BMJ Publishing Group Ltd. This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCMI Type	Text
DCTERMS.bibliographicCitation	BMJ Open. 2014, 4(6), p. e005067
DC.title	Association of lifestyle-related factors with circadian onset patterns of acute myocardial infarction: A prospective observational study in Japan
DC.creator	Edahiro, Ryuya
	Sakata, Yasuhiko
	Nakatani, Daisaku
	Suna, Shinichiro
	Usami, Masaya
	Matsumoto, Sen
	Hara, Masahiko
	Kitamura, Tetsuhisa
	Sato, Hiroshi
	Yamashita, Shizuya
	Nanto, Shinsuke
	Hikoso, Shungo
	Sakata, Yasushi
	Hori, Masatsugu
	Hamasaki, Toshimitsu
	Komuro, Issei
DC.publisher	BMJ Publishing Group
DC.language' scheme='DCTERMS.RFC1766	English
DC.type' scheme='DCTERMS.DCMIType	Text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2014-06-06
DC.identifier	https://doi.org/10.1136/bmjopen-2014-005067
DC.description	Edahiro R, Sakata Y, Nakatani D, et al. Association of lifestyle-related factors with circadian onset patterns of acute myocardial infarction: a prospective observational study in Japan. BMJ Open 2014;4:e005067. doi: 10.1136/bmjopen-2014-005067
DCTERMS.abstract	Objective: The onset of acute myocardial infarction (AMI) shows characteristic circadian variations involving a definite morning peak and a less-defined night-time peak. However, the factors influencing the circadian patterns of AMI onset and their influence on morning and night-time peaks have not been fully elucidated. Design, setting and participants: An analysis of patients registered between 1998 and 2008 in the Osaka Acute Coronary Insufficiency Study, which is a prospective, multicentre observational study of patients with AMI in the Osaka region of Japan. The present study included 7755 consecutive patients with a known time of AMI onset. Main outcomes and measures: A mixture of two von Mises distributions was used to examine whether a circadian pattern of AMI had uniform, unimodal or bimodal distribution, and the likelihood ratio test was then used to select the best circadian pattern among them. The hierarchical likelihood ratio test was used to identify factors affecting the circadian patterns of AMI onset. The Kaplan-Meier method was used to estimate survival curves of 1-year mortality according to AMI onset time. Results: The overall population had a bimodal circadian pattern of AMI onset characterised by a high and sharp morning peak and a lower and less-defined night-time peak (bimodal p<0.001). Although several lifestyle-related factors had a statistically significant association with the circadian patterns of AMI onset, serum triglyceride levels had the most prominent association with the circadian patterns of AMI onset. Patients with triglyceride ?150 mg/dL on admission had only one morning peak in the circadian pattern of AMI onset during weekdays, with no peaks detected on weekends, whereas all other subgroups had two peaks throughout the week. Conclusions: The circadian pattern of AMI onset was characterised by bimodality. Notably, several lifestyle-related factors, particularly serum triglyceride levels, had a strong relation with the circadian pattern of AMI onset.
DC.rights	© 2014 BMJ Publishing Group Ltd. This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License.
DC.format	78415
citation_title	Association of lifestyle-related factors with circadian onset patterns of acute myocardial infarction: A prospective observational study in Japan
citation_author	Edahiro, Ryuya
	Sakata, Yasuhiko
	Nakatani, Daisaku
	Suna, Shinichiro
	Usami, Masaya
	Matsumoto, Sen
	Hara, Masahiko
	Kitamura, Tetsuhisa
	Sato, Hiroshi
	Yamashita, Shizuya
	Nanto, Shinsuke
	Hikoso, Shungo
	Sakata, Yasushi
	Hori, Masatsugu
	Hamasaki, Toshimitsu
	Komuro, Issei
citation_publisher	BMJ Publishing Group
citation_language	English
citation_date	2014-06-06
citation_journal_title	BMJ Open
citation_volume	4
citation_issue	6
citation_firstpage	e005067
citation_doi	https://doi.org/10.1136/bmjopen-2014-005067
citation_pmid	24907246
citation_public_url	https://hdl.handle.net/11094/78415

Association of lifestyle-related factors with circadian onset patterns of acute myocardial infarction: A prospective observational study in Japan

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