Physiological function of seminal vesicle secretions on male fecundity

Noda, Taichi; Ikawa, Masahito

Reproductive Medicine and Biology, 2019, 18(3), 241-246

Number of Access:529（2025-08-22 01:06 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/78557

Link to primary information 

File Format Terms of use Size Views Date.Available Description information
ReprodMedBiol_18_03_241 pdf None 328 KB 164 2021.02.08  
Creative Commons : Attribution - NonCommercial

Item Information

Output File Export EndNote Basic Export Mendeley

Title
Physiological function of seminal vesicle secretions on male fecundity
Creator
NRID
1000050712551 1000050712551
CreatorName
Noda, Taichi
NRID
1000020304066 1000020304066
ORCID
0000-0001-9859-6217 0000-0001-9859-6217
researchmap permalink
read0054910 read0054910
Scopus Author ID
16689054500 16689054500
CreatorName
Ikawa, Masahito
Subject
artificial insemination
copulatory plug
male accessory gland
sperm fertilizing ability
uterine environment
Description
Noda, T, Ikawa, M. Physiological function of seminal vesicle secretions on male fecundity. Reprod Med Biol. 2019; 18: 241– 246. https://doi.org/10.1002/rmb2.12282
Abstract
Background: A mixture of spermatozoa and accessory gland secretions (from seminal vesicles, prostates, and coagulating glands) is ejaculated into the female reproductive tract at copulation. However, the physiological function of accessory glands on male fecundity remains unclear. Methods: Publications regarding the physiological functions of male accessory glands were summarized. Main findings (Results): The functions of accessory glands have been studied using male rodents surgically removed coagulating glands (CG), prostates (PR), or seminal vesicles (SV). CG-removed males are fertile or subfertile, while the fecundity of PR-removed males is controversial. SV-removed males show copulatory plug defects, leading to fewer sperm in the uterus and severe subfertility. TGM4, SVS2, and PATE4 were identified as essential factors for copulatory plug formation. When the sufficient number of epididymal spermatozoa was artificially injected into a uterus (AI method), they could efficiently fertilize oocytes, implicating that accessory gland secretions are not essential. Seminal vesicle secretions (SVSs) improved fertilization rates only when low numbers of spermatozoa were used for AI. The changes of uterine environment by SVSs could not improve the pregnancy rate. Conclusion: Accessory gland factors are critical for copulatory plug formation and support sperm fertilizing ability.
Publisher
John Wiley and Sons Ltd
Source Title
Reproductive Medicine and Biology
Volume (Issue)
18(3)
Page
241-246
Date of Issued
2019-07-08
Language
English
Handle URL
https://hdl.handle.net/11094/78557
PISSN
14455781
eISSN
14470578
NCID
AA11706516
Relation.isIdenticalTo
DOI (Publisher Version)
https://doi.org/10.1002/rmb2.12282
Access Rights
open access
CopyRight
© 2019 The Authors. Reproductive Medicine and Biology published by John Wiley & Sons Australia, Ltd on behalf of Japan Society for Reproductive Medicine. This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
oaire:version
Version of Record
Category
学術雑誌論文 Journal Article