MARCKSL1 Regulates Spine Formation in the Amygdala and Controls the Hypothalamic-Pituitary-Adrenal Axis and Anxiety-Like Behaviors

Tanaka, Takashi; Shimizu, Shoko; Ueno, Masaki; Fujihara, Yoshitaka; Ikawa, Masahito; Miyata, Shingo

doi:https://doi.org/10.1016/j.ebiom.2018.03.018

MARCKSL1 Regulates Spine Formation in the Amygdala and Controls the Hypothalamic-Pituitary-Adrenal Axis and Anxiety-Like Behaviors

Tanaka, Takashi; Shimizu, Shoko; Ueno, Masaki et al.

EBioMedicine, 2018, 30, 62-73

Number of Access:758（2025-08-22 01:06 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/78573

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Title	MARCKSL1 Regulates Spine Formation in the Amygdala and Controls the Hypothalamic-Pituitary-Adrenal Axis and Anxiety-Like Behaviors
Creator	NRID 1000030734694 1000030734694 CreatorName Tanaka, Takashi
	NRID 1000050572731 1000050572731 CreatorName Shimizu, Shoko
	NRID 1000040435631 1000040435631 CreatorName Ueno, Masaki
	NRID 1000070578848 1000070578848 CreatorName Fujihara, Yoshitaka
	NRID 1000020304066 1000020304066 ORCID 0000-0001-9859-6217 0000-0001-9859-6217 researchmap permalink read0054910 read0054910 Scopus Author ID 16689054500 16689054500 CreatorName Ikawa, Masahito
	NRID 1000070403194 1000070403194 CreatorName Miyata, Shingo
Subject	Amygdala
	Anxiety-like behaviors
	HPA axis
	MARCKSL1
	Spine formation
Description	Takashi Tanaka, Shoko Shimizu, Masaki Ueno, Yoshitaka Fujihara, Masahito Ikawa, Shingo Miyata, MARCKSL1 Regulates Spine Formation in the Amygdala and Controls the Hypothalamic-Pituitary-Adrenal Axis and Anxiety-Like Behaviors, EBioMedicine, Volume 30, 2018, Pages 62-73, ISSN 2352-3964, https://doi.org/10.1016/j.ebiom.2018.03.018.
Abstract	Abnormalities in limbic neural circuits have been implicated in the onset of anxiety disorders. However, the molecular pathogenesis underlying anxiety disorders remains poorly elucidated. Here, we demonstrate that myristoylated alanine-rich C-kinase substrate like 1 (MARCKSL1) regulates amygdala circuitry to control the activity of the hypothalamic-pituitary-adrenal (HPA) axis, as well as induces anxiety-like behaviors in mice. MARCKSL1 expression was predominantly localized in the prefrontal cortex (PFC), hypothalamus, hippocampus, and amygdala of the adult mouse brain. MARCKSL1 transgenic (Tg) mice exhibited anxiety-like behaviors dependent on corticotropin-releasing hormone. MARCKSL1 increased spine formation in the central amygdala, and downregulation of MARCKSL1 in the amygdala normalized both increased HPA axis activity and elevated anxiety-like behaviors in Tg mice. Furthermore, MARCKSL1 expression was increased in the PFC and amygdala in a brain injury model associated with anxiety-like behaviors. Our findings suggest that MARCKSL1 expression in the amygdala plays an important role in anxiety-like behaviors.
Publisher	Elsevier B.V.
Source Title	EBioMedicine
Volume (Issue)	30
Page	62-73
Date of Issued	2018-04
Language	English
Handle URL	https://hdl.handle.net/11094/78573
eISSN	23523964
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1016/j.ebiom.2018.03.018
Relation.isIdenticalTo	PMID 29580842
Access Rights	open access
CopyRight	© 2018 The Authors. Published by Elsevier B.V. This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCTERMS.bibliographicCitation	EBioMedicine. 2018, 30, p. 62-73
DC.title	MARCKSL1 Regulates Spine Formation in the Amygdala and Controls the Hypothalamic-Pituitary-Adrenal Axis and Anxiety-Like Behaviors
DC.creator	Tanaka, Takashi
	Shimizu, Shoko
	Ueno, Masaki
	Fujihara, Yoshitaka
	Ikawa, Masahito
	Miyata, Shingo
DC.publisher	Elsevier B.V.
DC.language' scheme='DCTERMS.RFC1766	English
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2018-04
DC.identifier	https://doi.org/10.1016/j.ebiom.2018.03.018
DC.subject	Amygdala
	Anxiety-like behaviors
	HPA axis
	MARCKSL1
	Spine formation
DC.description	Takashi Tanaka, Shoko Shimizu, Masaki Ueno, Yoshitaka Fujihara, Masahito Ikawa, Shingo Miyata, MARCKSL1 Regulates Spine Formation in the Amygdala and Controls the Hypothalamic-Pituitary-Adrenal Axis and Anxiety-Like Behaviors, EBioMedicine, Volume 30, 2018, Pages 62-73, ISSN 2352-3964, https://doi.org/10.1016/j.ebiom.2018.03.018.
DCTERMS.abstract	Abnormalities in limbic neural circuits have been implicated in the onset of anxiety disorders. However, the molecular pathogenesis underlying anxiety disorders remains poorly elucidated. Here, we demonstrate that myristoylated alanine-rich C-kinase substrate like 1 (MARCKSL1) regulates amygdala circuitry to control the activity of the hypothalamic-pituitary-adrenal (HPA) axis, as well as induces anxiety-like behaviors in mice. MARCKSL1 expression was predominantly localized in the prefrontal cortex (PFC), hypothalamus, hippocampus, and amygdala of the adult mouse brain. MARCKSL1 transgenic (Tg) mice exhibited anxiety-like behaviors dependent on corticotropin-releasing hormone. MARCKSL1 increased spine formation in the central amygdala, and downregulation of MARCKSL1 in the amygdala normalized both increased HPA axis activity and elevated anxiety-like behaviors in Tg mice. Furthermore, MARCKSL1 expression was increased in the PFC and amygdala in a brain injury model associated with anxiety-like behaviors. Our findings suggest that MARCKSL1 expression in the amygdala plays an important role in anxiety-like behaviors.
DC.rights	© 2018 The Authors. Published by Elsevier B.V. This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
DC.format	78573
citation_title	MARCKSL1 Regulates Spine Formation in the Amygdala and Controls the Hypothalamic-Pituitary-Adrenal Axis and Anxiety-Like Behaviors
citation_author	Tanaka, Takashi
	Shimizu, Shoko
	Ueno, Masaki
	Fujihara, Yoshitaka
	Ikawa, Masahito
	Miyata, Shingo
citation_publisher	Elsevier B.V.
citation_language	English
citation_date	2018-04
citation_journal_title	EBioMedicine
citation_volume	30
citation_firstpage	62
citation_lastpage	73
citation_doi	https://doi.org/10.1016/j.ebiom.2018.03.018
citation_pmid	29580842
citation_public_url	https://hdl.handle.net/11094/78573

MARCKSL1 Regulates Spine Formation in the Amygdala and Controls the Hypothalamic-Pituitary-Adrenal Axis and Anxiety-Like Behaviors

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