The mechanism of sperm-egg interaction and the involvement of IZUMO1 in fusion

Inoue, Naokazu; Ikawa, Masahito; Okabe, Masaru

Asian Journal of Andrology, 2011, 13(1), 81-87

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Identifier to cite or link to this item: https://hdl.handle.net/11094/78615

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Title
The mechanism of sperm-egg interaction and the involvement of IZUMO1 in fusion
Creator
NRID
1000050379096 1000050379096
CreatorName
Inoue, Naokazu
NRID
1000020304066 1000020304066
ORCID
0000-0001-9859-6217 0000-0001-9859-6217
researchmap permalink
read0054910 read0054910
Scopus Author ID
16689054500 16689054500
CreatorName
Ikawa, Masahito
NRID
1000030089875 1000030089875
CreatorName
Okabe, Masaru
Subject
egg
fusion
gene-manipulation
interaction
IZUMO1
sperm
zona pellucida
Description
Inoue, N., Ikawa, M., & Okabe, M. (2011). The mechanism of sperm-egg interaction and the involvement of IZUMO1 in fusion. Asian Journal of Andrology, 13(1), 81-87. doi:10.1038/aja.2010.70
Abstract
An average human ejaculate contains over 100 million sperm, but only a few succeed in accomplishing the journey to an egg by migration through the female reproductive tract. Among these few sperm, only one participates in fertilization. There might be an ingenious molecular mechanism to ensure that the very best sperm fertilize an egg. However, recent gene disruption experiments in mice have revealed that many factors previously described as important for fertilization are largely dispensable. One could argue that the fertilization mechanism is made robust against gene disruptions. However, this is not likely, as there are already six different gene-disrupted mouse lines (Calmegin, Adam1a, Adam2, Adam3, Ace and Pgap1), all of which result in male sterility. The sperm from these animals are known to have defective zona-binding ability and at the same time lose oviduct-migrating ability. Concerning sperm-zona binding, the widely accepted involvement of sugar moiety on zona pellucida 3 (ZP3) is indicated to be dispensable by gene disruption experiments. Thus, the landscape of the mechanism of fertilization is revolving considerably. In the sperm-egg fusion process, CD9 on egg and IZUMO1 on sperm have emerged as essential factors. This review focuses on the mechanism of fertilization elucidated by gene-manipulated animals.
Publisher
Asian Society of Andrology
Source Title
Asian Journal of Andrology
Volume (Issue)
13(1)
Page
81-87
Date of Issued
2011-01
Language
English
Handle URL
https://hdl.handle.net/11094/78615
PISSN
1008682X
eISSN
17457262
NCID
AA11693946
Relation.isIdenticalTo
DOI (Publisher Version)
https://doi.org/10.1038/aja.2010.70
PMID
21057513
Access Rights
open access
CopyRight
© 2011 AJA, SIMM & SJTU. All rights reserved. Published under the Creative Commons Attribution‐Non Commercial‐Share Alike 3.0 licence
oaire:version
Version of Record
Category
学術雑誌論文 Journal Article