Renin-angiotensin-aldosterone system polymorphisms and 5-year mortality in survivors of acute myocardial infarction a report from the osaka acute coronary insuffi ciency study

Hara, Masahiko; Sakata, Yasuhiko; Nakatani, Daisaku; Suna, Shinichiro; Usami, Masaya; Matsumoto, Sen; Sugitani, Toshifumi; Ozaki, Kouichi; Nishino, Masami; Sato, Hiroshi; Kitamura, Tetsuhisa; Nanto, Shinsuke; Hamasaki, Toshimitsu; Tanaka, Toshihiro; Hori, Masatsugu; Komuro, Issei

doi:https://doi.org/10.1536/ihj.13-288

Renin-angiotensin-aldosterone system polymorphisms and 5-year mortality in survivors of acute myocardial infarction a report from the osaka acute coronary insuffi ciency study

Hara, Masahiko; Sakata, Yasuhiko; Nakatani, Daisaku et al.

International Heart Journal, 2014, 55(3), 190-196

Number of Access:1,409（2025-08-14 00:09 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/78723

Link to primary information

File	Format	Terms of use	Size	Views	Date.Available	Description	information
IntHeartJ_55_03_190	pdf	None	897 KB	111	2021.02.12

Item Information

Output File Export EndNote Basic Export Mendeley

Title	Renin-angiotensin-aldosterone system polymorphisms and 5-year mortality in survivors of acute myocardial infarction a report from the osaka acute coronary insuffi ciency study
Creator	CreatorName Hara, Masahiko
	NRID 1000090379206 1000090379206 CreatorName Sakata, Yasuhiko
	NRID 1000060444535 1000060444535 researchmap permalink dsyma dsyma Scopus Author ID 6603545219 6603545219 CreatorName Nakatani, Daisaku
	NRID 1000040573085 1000040573085 CreatorName Suna, Shinichiro
	CreatorName Usami, Masaya
	CreatorName Matsumoto, Sen
	NRID 1000070626879 1000070626879 CreatorName Sugitani, Toshifumi
	CreatorName Ozaki, Kouichi
	CreatorName Nishino, Masami
	NRID 1000010294092 1000010294092 CreatorName Sato, Hiroshi
	NRID 1000030639810 1000030639810 ORCID 0000-0003-0107-0580 0000-0003-0107-0580 researchmap permalink Kitamura_T Kitamura_T Scopus Author ID 22234282700 22234282700 CreatorName Kitamura, Tetsuhisa
	CreatorName Nanto, Shinsuke
	NRID 1000040379243 1000040379243 CreatorName Hamasaki, Toshimitsu
	NRID 1000050292850 1000050292850 CreatorName Tanaka, Toshihiro
	CreatorName Hori, Masatsugu
	NRID 1000030260483 1000030260483 CreatorName Komuro, Issei
Subject	Genetics
Subject	Secondary prevention
Abstract	This study sought to evaluate whether genetic variants in the renin-angiotensin-aldosterone system (RAAS) have an impact on long-term mortality after acute myocardial infarction (AMI) in the percutaneous coronary intervention (PCI) era. We investigated the impacts of individual and combinations of 4 major RAAS genetic variants, angiotensinogen (AGT) T1311C, angiotensin-converting enzyme (ACE) insertion/deletion (I/D), angiotensin 2 type 1 receptor A1166C, and aldosterone synthase T4660C on 5-year mortality in 3149 post-AMI patients using multivariate Cox regression analysis. The predictive accuracy of all possible RAAS genetic combinations was evaluated using Cox regression analysis, and the best combination that affected prognosis was determined based on the minimal Akaike Information Criterion. There were 220 deaths during a median follow-up of 4.9 years. Independent analyses of any single RAAS variant did not show signifi cant impacts on 5-year mortality. However, analyses in combination revealed that absence of both AGT CC genotype and ACE D allele was associated with lower 5-year mortality (log-rank P = 0.005). Patients with at least either of the AGT CC or ACE D allele had increased mortality with adjusted hazard ratios of 2.07 (95% confi dence interval 1.18-3.65, P = 0.012), compared with those with neither the AGT CC nor ACE D allele. Among the 4 RAAS genetic variants examined, a combination of AGT and ACE polymorphisms was associated with 5-year mortality after AMI.
Publisher	International Heart Journal Association
Source Title	International Heart Journal
Volume (Issue)	55(3)
Page	190-196
Date of Issued	2014-05-26
Language	English
Handle URL	https://hdl.handle.net/11094/78723
PISSN	13492365
eISSN	13493299
NCID	AA12013242
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1536/ihj.13-288
Relation.isIdenticalTo	PMID 24806378
Access Rights	open access
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCTERMS.bibliographicCitation	International Heart Journal. 2014, 55(3), p. 190-196
DC.title	Renin-angiotensin-aldosterone system polymorphisms and 5-year mortality in survivors of acute myocardial infarction a report from the osaka acute coronary insuffi ciency study
DC.creator	Hara, Masahiko
	Sakata, Yasuhiko
	Nakatani, Daisaku
	Suna, Shinichiro
	Usami, Masaya
	Matsumoto, Sen
	Sugitani, Toshifumi
	Ozaki, Kouichi
	Nishino, Masami
	Sato, Hiroshi
	Kitamura, Tetsuhisa
	Nanto, Shinsuke
	Hamasaki, Toshimitsu
	Tanaka, Toshihiro
	Hori, Masatsugu
	Komuro, Issei
DC.publisher	International Heart Journal Association
DC.language' scheme='DCTERMS.RFC1766	English
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2014-05-26
DC.identifier	https://doi.org/10.1536/ihj.13-288
DC.subject	Genetics
DC.subject	Secondary prevention
DCTERMS.abstract	This study sought to evaluate whether genetic variants in the renin-angiotensin-aldosterone system (RAAS) have an impact on long-term mortality after acute myocardial infarction (AMI) in the percutaneous coronary intervention (PCI) era. We investigated the impacts of individual and combinations of 4 major RAAS genetic variants, angiotensinogen (AGT) T1311C, angiotensin-converting enzyme (ACE) insertion/deletion (I/D), angiotensin 2 type 1 receptor A1166C, and aldosterone synthase T4660C on 5-year mortality in 3149 post-AMI patients using multivariate Cox regression analysis. The predictive accuracy of all possible RAAS genetic combinations was evaluated using Cox regression analysis, and the best combination that affected prognosis was determined based on the minimal Akaike Information Criterion. There were 220 deaths during a median follow-up of 4.9 years. Independent analyses of any single RAAS variant did not show signifi cant impacts on 5-year mortality. However, analyses in combination revealed that absence of both AGT CC genotype and ACE D allele was associated with lower 5-year mortality (log-rank P = 0.005). Patients with at least either of the AGT CC or ACE D allele had increased mortality with adjusted hazard ratios of 2.07 (95% confi dence interval 1.18-3.65, P = 0.012), compared with those with neither the AGT CC nor ACE D allele. Among the 4 RAAS genetic variants examined, a combination of AGT and ACE polymorphisms was associated with 5-year mortality after AMI.
DC.format	78723
citation_title	Renin-angiotensin-aldosterone system polymorphisms and 5-year mortality in survivors of acute myocardial infarction a report from the osaka acute coronary insuffi ciency study
citation_author	Hara, Masahiko
	Sakata, Yasuhiko
	Nakatani, Daisaku
	Suna, Shinichiro
	Usami, Masaya
	Matsumoto, Sen
	Sugitani, Toshifumi
	Ozaki, Kouichi
	Nishino, Masami
	Sato, Hiroshi
	Kitamura, Tetsuhisa
	Nanto, Shinsuke
	Hamasaki, Toshimitsu
	Tanaka, Toshihiro
	Hori, Masatsugu
	Komuro, Issei
citation_publisher	International Heart Journal Association
citation_language	English
citation_date	2014-05-26
citation_journal_title	International Heart Journal
citation_volume	55
citation_issue	3
citation_firstpage	190
citation_lastpage	196
citation_doi	https://doi.org/10.1536/ihj.13-288
citation_pmid	24806378
citation_public_url	https://hdl.handle.net/11094/78723

Renin-angiotensin-aldosterone system polymorphisms and 5-year mortality in survivors of acute myocardial infarction a report from the osaka acute coronary insuffi ciency study

Link to primary information

Item Information

Show details