Low levels of serum n-3 polyunsaturated fatty acids are associated with worse heart failure-free survival in patients after acute myocardial infarction

Hara, Masahiko; Sakata, Yasuhiko; Nakatani, Daisaku; Suna, Shinichiro; Usami, Masaya; Matsumoto, Sen; Hamasaki, Toshimitsu; Doi, Yasuji; Nishino, Masami; Sato, Hiroshi; Kitamura, Tetsuhisa; Nanto, Shinsuke; Hori, Masatsugu; Komuro, Issei

doi:https://doi.org/10.1253/circj.CJ-12-0875

Low levels of serum n-3 polyunsaturated fatty acids are associated with worse heart failure-free survival in patients after acute myocardial infarction

Hara, Masahiko; Sakata, Yasuhiko; Nakatani, Daisaku et al.

Circulation Journal, 2012, 77(1), 153-162

Number of Access:1,168（2025-08-14 02:42 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/78934

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Title	Low levels of serum n-3 polyunsaturated fatty acids are associated with worse heart failure-free survival in patients after acute myocardial infarction
Creator	CreatorName Hara, Masahiko
	NRID 1000090379206 1000090379206 CreatorName Sakata, Yasuhiko
	NRID 1000060444535 1000060444535 researchmap permalink dsyma dsyma Scopus Author ID 6603545219 6603545219 CreatorName Nakatani, Daisaku
	NRID 1000040573085 1000040573085 CreatorName Suna, Shinichiro
	CreatorName Usami, Masaya
	CreatorName Matsumoto, Sen
	NRID 1000040379243 1000040379243 CreatorName Hamasaki, Toshimitsu
	CreatorName Doi, Yasuji
	CreatorName Nishino, Masami
	NRID 1000010294092 1000010294092 CreatorName Sato, Hiroshi
	NRID 1000030639810 1000030639810 ORCID 0000-0003-0107-0580 0000-0003-0107-0580 researchmap permalink Kitamura_T Kitamura_T Scopus Author ID 22234282700 22234282700 CreatorName Kitamura, Tetsuhisa
	CreatorName Nanto, Shinsuke
	CreatorName Hori, Masatsugu
	NRID 1000030260483 1000030260483 CreatorName Komuro, Issei
Subject	Acute myocardial infarction
	Docosahexaenoic acid
	Eicosapentaenoic acid
	Heart failure
	N-3 polyunsaturated fatty acids
Description	Masahiko Hara, Yasuhiko Sakata, Daisaku Nakatani, Shinichiro Suna, Masaya Usami, Sen Matsumoto, Toshimitsu Hamasaki, Yasuji Doi, Masami Nishino, Hiroshi Sato, Tetsuhisa Kitamura, Shinsuke Nanto, Masatsugu Hori, Issei Komuro, for the Osaka Acute Coronary Insufficiency Study (OACIS) Investigators, Low Levels of Serum n-3 Polyunsaturated Fatty Acids Are Associated With Worse Heart Failure-Free Survival in Patients After Acute Myocardial Infarction, Circulation Journal, 2013, Volume 77, Issue 1, Pages 153-162, Released December 25, 2012, [Advance publication] Released October 06, 2012, Online ISSN 1347-4820, Print ISSN 1346-9843, https://doi.org/10.1253/circj.CJ-12-0875, https://www.jstage.jst.go.jp/article/circj/77/1/77_CJ-12-0875/_article/-char/en
Abstract	Background: Intake of long-chain n-3 polyunsaturated fatty acids (n-3 PUFA), including docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), is associated with a lower risk of atherosclerotic cardiovascular events, particularly acute myocardial infarction (AMI). However, limited data are available regarding the association between serum n-3 PUFA levels and heart failure (HF) events in survivors of AMI. Methods and Results: We evaluated whether serum DHA and EPA levels were associated with HF-free survival and HF hospitalization rates after AMI. A total of 712 patients were divided into 3 groups according to their tertile serum levels of DHA and EPA (Low, Middle, and High). Propensity-score-stratified Cox regression analysis revealed that DHA- and EPA-Low groups presented statistically significant worse HF-free survival (hazard ratio (HR) 1.68, 95% confidence interval (CI) 1.03-2.72, P=0.0358, and HR 1.69, 95% CI 1.05-2.72, P=0.0280, respectively), with the EPALow group having a higher risk of HF hospitalization (HR 2.40, 95% CI 1.21-4.75, P=0.0097) than the DHA-Low group (HR 1.72, 95% CI 0.86-3.45, P=0.1224). The relationship between a low DHA or EPA level and decreased HF-free survival was almost common to all subgroups; however, the effect of low serum EPA on HF hospitalization was prominent in male patients, and those with low levels of high-density lipoprotein cholesterol or without statin therapy. Conclusions: Low levels of circulating n-3 PUFA are associated with decreased HF-free survival in post-AMI patients.
Publisher	Japanese Circulation Society
Source Title	Circulation Journal
Volume (Issue)	77(1)
Page	153-162
Date of Issued	2012-12-25
Language	English
Handle URL	https://hdl.handle.net/11094/78934
PISSN	13469843
eISSN	13474820
NCID	AA11591968
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1253/circj.CJ-12-0875
Relation.isIdenticalTo	PMID 23047296
Access Rights	open access
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCTERMS.bibliographicCitation	Circulation Journal. 2012, 77(1), p. 153-162
DC.title	Low levels of serum n-3 polyunsaturated fatty acids are associated with worse heart failure-free survival in patients after acute myocardial infarction
DC.creator	Hara, Masahiko
	Sakata, Yasuhiko
	Nakatani, Daisaku
	Suna, Shinichiro
	Usami, Masaya
	Matsumoto, Sen
	Hamasaki, Toshimitsu
	Doi, Yasuji
	Nishino, Masami
	Sato, Hiroshi
	Kitamura, Tetsuhisa
	Nanto, Shinsuke
	Hori, Masatsugu
	Komuro, Issei
DC.publisher	Japanese Circulation Society
DC.language' scheme='DCTERMS.RFC1766	English
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2012-12-25
DC.identifier	https://doi.org/10.1253/circj.CJ-12-0875
DC.subject	Acute myocardial infarction
	Docosahexaenoic acid
	Eicosapentaenoic acid
	Heart failure
	N-3 polyunsaturated fatty acids
DC.description	Masahiko Hara, Yasuhiko Sakata, Daisaku Nakatani, Shinichiro Suna, Masaya Usami, Sen Matsumoto, Toshimitsu Hamasaki, Yasuji Doi, Masami Nishino, Hiroshi Sato, Tetsuhisa Kitamura, Shinsuke Nanto, Masatsugu Hori, Issei Komuro, for the Osaka Acute Coronary Insufficiency Study (OACIS) Investigators, Low Levels of Serum n-3 Polyunsaturated Fatty Acids Are Associated With Worse Heart Failure-Free Survival in Patients After Acute Myocardial Infarction, Circulation Journal, 2013, Volume 77, Issue 1, Pages 153-162, Released December 25, 2012, [Advance publication] Released October 06, 2012, Online ISSN 1347-4820, Print ISSN 1346-9843, https://doi.org/10.1253/circj.CJ-12-0875, https://www.jstage.jst.go.jp/article/circj/77/1/77_CJ-12-0875/_article/-char/en
DCTERMS.abstract	Background: Intake of long-chain n-3 polyunsaturated fatty acids (n-3 PUFA), including docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), is associated with a lower risk of atherosclerotic cardiovascular events, particularly acute myocardial infarction (AMI). However, limited data are available regarding the association between serum n-3 PUFA levels and heart failure (HF) events in survivors of AMI. Methods and Results: We evaluated whether serum DHA and EPA levels were associated with HF-free survival and HF hospitalization rates after AMI. A total of 712 patients were divided into 3 groups according to their tertile serum levels of DHA and EPA (Low, Middle, and High). Propensity-score-stratified Cox regression analysis revealed that DHA- and EPA-Low groups presented statistically significant worse HF-free survival (hazard ratio (HR) 1.68, 95% confidence interval (CI) 1.03-2.72, P=0.0358, and HR 1.69, 95% CI 1.05-2.72, P=0.0280, respectively), with the EPALow group having a higher risk of HF hospitalization (HR 2.40, 95% CI 1.21-4.75, P=0.0097) than the DHA-Low group (HR 1.72, 95% CI 0.86-3.45, P=0.1224). The relationship between a low DHA or EPA level and decreased HF-free survival was almost common to all subgroups; however, the effect of low serum EPA on HF hospitalization was prominent in male patients, and those with low levels of high-density lipoprotein cholesterol or without statin therapy. Conclusions: Low levels of circulating n-3 PUFA are associated with decreased HF-free survival in post-AMI patients.
DC.format	78934
citation_title	Low levels of serum n-3 polyunsaturated fatty acids are associated with worse heart failure-free survival in patients after acute myocardial infarction
citation_author	Hara, Masahiko
	Sakata, Yasuhiko
	Nakatani, Daisaku
	Suna, Shinichiro
	Usami, Masaya
	Matsumoto, Sen
	Hamasaki, Toshimitsu
	Doi, Yasuji
	Nishino, Masami
	Sato, Hiroshi
	Kitamura, Tetsuhisa
	Nanto, Shinsuke
	Hori, Masatsugu
	Komuro, Issei
citation_publisher	Japanese Circulation Society
citation_language	English
citation_date	2012-12-25
citation_journal_title	Circulation Journal
citation_volume	77
citation_issue	1
citation_firstpage	153
citation_lastpage	162
citation_doi	https://doi.org/10.1253/circj.CJ-12-0875
citation_pmid	23047296
citation_public_url	https://hdl.handle.net/11094/78934

Low levels of serum n-3 polyunsaturated fatty acids are associated with worse heart failure-free survival in patients after acute myocardial infarction

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