The chromosome peripheral proteins play an active role in chromosome dynamics

Matsunaga, Sachihiro; Fukui, Kiichi

Biomolecular Concepts, 2010, 1(2), 157-164

Number of Access:282（2025-08-14 18:27 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/78971

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Title
The chromosome peripheral proteins play an active role in chromosome dynamics
Creator
NRID
1000040323448 1000040323448
CreatorName
Matsunaga, Sachihiro
NRID
1000000311770 1000000311770
researchmap permalink
read0068600 read0068600
CreatorName
Fukui, Kiichi
Subject
cell division
chromosome dynamics
chromosome periphery
chromosome surface
nucleolar proteins
Description
Matsunaga, Sachihiro and Fukui, Kiichi. "The chromosome peripheral proteins play an active role in chromosome dynamics" , vol. 1, no. 2, 2010, pp. 157-164. https://doi.org/10.1515/bmc.2010.018
Abstract
The chromosome periphery is a chromosomal structure that covers the surface of mitotic chromosomes. The structure and function of the chromosome periphery has been poorly understood since its first description in 1882. It has, however, been proposed to be an insulator or barrier to protect chromosomes from subcellular substances and to act as a carrier of nuclear and nucleolar components to direct their equal distribution to daughter cells because most chromosome peripheral proteins (CPPs) are derived from the nucleolus or nucleus. Until now, more than 30 CPPs were identified in mammalians. Recent immunostaining analyses of CPPs have revealed that the chromosome periphery covers the centromeric region of mitotic chromosomes in addition to telomeres and regions between two sister chromatids. Knockdown analyses of CPPs using RNAi have revealed functions in chromosome dynamics, including cohesion of sister chromatids, kinetochore-microtubule attachments, spindle assembly and chromosome segregation. Because most CPPs are involved in various subcellular events in the nucleolus or nuclear at interphase, a temporal and spatial-specific knockdown method of CPPs in the chromosome periphery will be useful to understand the function of chromosome periphery in cell division.
Publisher
De Gruyter Mouton
Source Title
Biomolecular Concepts
Volume (Issue)
1(2)
Page
157-164
Date of Issued
2010
Language
English
Handle URL
https://hdl.handle.net/11094/78971
PISSN
18685021
eISSN
1868503X
Relation.isIdenticalTo
DOI (Publisher Version)
https://doi.org/10.1515/bmc.2010.018
Access Rights
open access
oaire:version
Version of Record
Category
学術雑誌論文 Journal Article