Interdependency and phosphorylation of KIF4 and condensin I are essential for organization of chromosome scaffold

Poonperm, Rawin; Takata, Hideaki; Uchiyama, Susumu et al.

PLoS ONE, 2017, 12(8), e0183298

Number of Access:632（2025-08-15 01:09 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/79027

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Title
Interdependency and phosphorylation of KIF4 and condensin I are essential for organization of chromosome scaffold
Creator
NRID
1000040774790 1000040774790
CreatorName
Poonperm, Rawin
NRID
1000020455207 1000020455207
CreatorName
Takata, Hideaki
NRID
1000090335381 1000090335381
ORCID
0000-0002-5181-179X 0000-0002-5181-179X
researchmap permalink
read0090387 read0090387
Scopus Author ID
35429790100 35429790100
CreatorName
Uchiyama, Susumu
NRID
1000000311770 1000000311770
researchmap permalink
read0068600 read0068600
CreatorName
Fukui, Kiichi
Description
Poonperm R, Takata H, Uchiyama S, Fukui K (2017) Interdependency and phosphorylation of KIF4 and condensin I are essential for organization of chromosome scaffold. PLOS ONE 12(8): e0183298. https://doi.org/10.1371/journal.pone.0183298.
Abstract
Kinesin family member 4 (KIF4) and condensins I and II are essential chromosomal proteins for chromosome organization by locating primarily to the chromosome scaffold. However, the mechanism of how KIF4 and condensins localize to the chromosome scaffold is poorly understood. Here, we demonstrate a close relationship between the chromosome localization of KIF4 and condensin I, but not condensin II, and show that KIF4 and condensin I assist each other for stable scaffold formation by forming a stable complex. Moreover, phosphorylation of KIF4 and condensin I by Aurora B and polo-like kinase 1 (Plk1) is important for KIF4 and condensin I localization to the chromosome. Aurora B activity facilitates the targeting of KIF4 and condensin I to the chromosome, whereas Plk1 activity promotes the dissociation of these proteins from the chromosome. Thus, the interdependency between KIF4 and condensin I, and their phosphorylation states play important roles in chromosome scaffold organization during mitosis.
Publisher
Public Library of Science
Source Title
PLoS ONE
Volume (Issue)
12(8)
Page
e0183298
Date of Issued
2017-08-17
Language
English
Handle URL
https://hdl.handle.net/11094/79027
eISSN
19326203
Relation.isIdenticalTo
DOI (Publisher Version)
https://doi.org/10.1371/journal.pone.0183298
PMID
28817632
Access Rights
open access
CopyRight
© 2017 Poonperm et al. This article is licensed under a Creative Commons Attribution 4.0 International License.
oaire:version
Version of Record
Category
学術雑誌論文 Journal Article