Ultrahigh-sensitive wireless QCM with bio-nanocapsules

Noi, Kentaro; Iijima, Masumi; Kuroda, Shun'ichi et al.

Sensors and Actuators B: Chemical, 2019, 293, 59-62

Number of Access:445（2025-07-18 10:00 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/84135

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Title
Ultrahigh-sensitive wireless QCM with bio-nanocapsules
Creator
NRID
1000030588405 1000030588405
CreatorName
Noi, Kentaro
NRID
1000040390728 1000040390728
CreatorName
Iijima, Masumi
NRID
1000060263406 1000060263406
researchmap permalink
read0186039 read0186039
CreatorName
Kuroda, Shun'ichi
NRID
1000090252626 1000090252626
researchmap permalink
read0042771 read0042771
Scopus Author ID
35563683500 35563683500
CreatorName
Ogi, Hirotsugu
Subject
QCM
Bio-nanocapsule
Multichannel
Wireless
CRP
Abstract
Quartz-crystal-microbalance (QCM)biosensor is a mass-sensitive biosensor, and its sensitivity in detecting target proteins can be improved with weighted detection antibodies. In this communication, we propose a mass-amplified detection of biomarkers by bio-nanocapsules (BNCs)in wireless high-frequency multichannel QCM biosensor. BNC exhibits molecular mass of 6.57 MDa and possesses many immunoglobulin-G (IgG)Fc-binding Z domains on its surface, making it possible to display ∼60 antibodies in an oriented immobilization manner. We find that by reinforcing the bond strength between the Z domain and the Fc part of antibody with the cross-linker, a high sensitive detection of biomarkers with QCM is realized. We used multichanel wireless QCM system with fundamental resonance frequencies above 54 MHz and performed detection of C-reactive protein. The detection limit is lower than 10 pg/mL, confirming that combination of BNC and wireless high-frequency QCM allows high sensitivity detection of biomarkers.
Publisher
Elsevier B.V.
Source Title
Sensors and Actuators B: Chemical
Volume (Issue)
293
Page
59-62
Date of Issued
2019-08-15
Language
English
Handle URL
https://hdl.handle.net/11094/84135
PISSN
09254005
NCID
AA1078104X
Relation.isVersionOf
DOI (Publisher Version)
https://doi.org/10.1016/j.snb.2019.04.150
Access Rights
open access
CopyRight
© 2019 Elsevier B.V. This manuscript version is made available under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
oaire:version
Accepted Manuscript
Category
学術雑誌論文 Journal Article