Isolated electrodeless high-frequency quartz crystal microbalance for immunosensors

Ogi, Hirotsugu; Motoshisa, Kazuma; Matsumoto, Takashi; Hatanaka, Kenichi; Hirao, Masahiko

doi:https://doi.org/10.1021/ac061004a

Isolated electrodeless high-frequency quartz crystal microbalance for immunosensors

Ogi, Hirotsugu; Motoshisa, Kazuma; Matsumoto, Takashi et al.

Analytical Chemistry, 2006, 78(19), 6903-6909

Number of Access:622（2025-08-23 19:12 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/84136

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Title	Isolated electrodeless high-frequency quartz crystal microbalance for immunosensors
Creator	NRID 1000090252626 1000090252626 researchmap permalink read0042771 read0042771 Scopus Author ID 35563683500 35563683500 CreatorName Ogi, Hirotsugu
	CreatorName Motoshisa, Kazuma
	CreatorName Matsumoto, Takashi
	CreatorName Hatanaka, Kenichi
	NRID 1000080112027 1000080112027 CreatorName Hirao, Masahiko
Description	Hirotsugu Ogi, Kazuma Motoshisa, Takashi Matsumoto, Kenichi Hatanaka, and Masahiko Hirao. Isolated electrodeless high-frequency quartz crystal microbalance for immunosensors. Analytical Chemistry, 2006, 78(19), 6903-6909. ©2006 American Chemical Society. https://doi.org/10.1021/ac061004a.
Abstract	This paper presents a contactless technique to measure shear bulk wave resonance frequencies of an isolated quartz crystal in a flow cell. The line antenna placed outside the cell generates and detects the resonance frequencies in a wireless-electrodeless manner. It is revealed that this mechanism relies on the quasistatic electric field. A 0.3-mm-thick AT-cut quartz was used, and its overtone resonance frequencies up to 80 MHz were measured in liquids. Exact vibrational analysis was carried out for a triple-layered resonator system consisting of the adsorbed material layer, the electrode film, and the quartz plate. It predicts higher frequency sensitivity to the adsorbed material at higher modes when the electrode layer is removed. The 13th overtone (72-MHz resonance frequency) was used to detect human immunoglobulin G with concentrations between 0.1 and 20 μg/mL captured by protein A immobilized on one side of the crystal. The real-time measurement of the frequency response yielded the equilibrium constant KA=5.21 × 10⁷M⁻¹.
Publisher	American Chemical Society
Source Title	Analytical Chemistry
Volume (Issue)	78(19)
Page	6903-6909
Date of Issued	2006-10-01
Language	English
Handle URL	https://hdl.handle.net/11094/84136
PISSN	00032700
eISSN	15206882
NCID	AA00524878
Relation.isVersionOf	DOI (Publisher Version) https://doi.org/10.1021/ac061004a
Relation.isIdenticalTo	PMID 17007513
Access Rights	open access
CopyRight	This document is the Accepted Manuscript version of a Published Work that appeared in final form in Analytical Chemistry, © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/ac061004a.
oaire:version	Accepted Manuscript
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCMI Type	Text
DCTERMS.bibliographicCitation	Analytical Chemistry. 2006, 78(19), p. 6903-6909
DC.title	Isolated electrodeless high-frequency quartz crystal microbalance for immunosensors
DC.creator	Ogi, Hirotsugu
	Motoshisa, Kazuma
	Matsumoto, Takashi
	Hatanaka, Kenichi
	Hirao, Masahiko
DC.publisher	American Chemical Society
DC.language' scheme='DCTERMS.RFC1766	English
DC.type' scheme='DCTERMS.DCMIType	Text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2006-10-01
DC.identifier	https://doi.org/10.1021/ac061004a
DC.description	Hirotsugu Ogi, Kazuma Motoshisa, Takashi Matsumoto, Kenichi Hatanaka, and Masahiko Hirao. Isolated electrodeless high-frequency quartz crystal microbalance for immunosensors. Analytical Chemistry, 2006, 78(19), 6903-6909. ©2006 American Chemical Society. https://doi.org/10.1021/ac061004a.
DCTERMS.abstract	This paper presents a contactless technique to measure shear bulk wave resonance frequencies of an isolated quartz crystal in a flow cell. The line antenna placed outside the cell generates and detects the resonance frequencies in a wireless-electrodeless manner. It is revealed that this mechanism relies on the quasistatic electric field. A 0.3-mm-thick AT-cut quartz was used, and its overtone resonance frequencies up to 80 MHz were measured in liquids. Exact vibrational analysis was carried out for a triple-layered resonator system consisting of the adsorbed material layer, the electrode film, and the quartz plate. It predicts higher frequency sensitivity to the adsorbed material at higher modes when the electrode layer is removed. The 13th overtone (72-MHz resonance frequency) was used to detect human immunoglobulin G with concentrations between 0.1 and 20 μg/mL captured by protein A immobilized on one side of the crystal. The real-time measurement of the frequency response yielded the equilibrium constant KA=5.21 × 10⁷M⁻¹.
DC.rights	This document is the Accepted Manuscript version of a Published Work that appeared in final form in Analytical Chemistry, © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/ac061004a.
DC.format	84136
citation_title	Isolated electrodeless high-frequency quartz crystal microbalance for immunosensors
citation_author	Ogi, Hirotsugu
	Motoshisa, Kazuma
	Matsumoto, Takashi
	Hatanaka, Kenichi
	Hirao, Masahiko
citation_publisher	American Chemical Society
citation_language	English
citation_date	2006-10-01
citation_journal_title	Analytical Chemistry
citation_volume	78
citation_issue	19
citation_firstpage	6903
citation_lastpage	6909
citation_doi	https://doi.org/10.1021/ac061004a
citation_pmid	17007513
citation_public_url	https://hdl.handle.net/11094/84136

Isolated electrodeless high-frequency quartz crystal microbalance for immunosensors

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