Label-free ultrathin Pt film biosensor using phonon vibrations excited by ultrafast light pulses

Ogi, Hirotsugu; Matsumoto, Kozo; Fujita, Yusaku; Kawamoto, Tetsuya; Nakamura, Nobutomo; Hirao, Masahiko

doi:https://doi.org/10.1143/APEX.3.017001

Label-free ultrathin Pt film biosensor using phonon vibrations excited by ultrafast light pulses

Ogi, Hirotsugu; Matsumoto, Kozo; Fujita, Yusaku et al.

Applied Physics Express, 2009, 3(1), 017001

Number of Access:140（2025-04-26 13:10 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/84154

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Title	Label-free ultrathin Pt film biosensor using phonon vibrations excited by ultrafast light pulses
Creator	NRID 1000090252626 1000090252626 researchmap permalink read0042771 read0042771 Scopus Author ID 35563683500 35563683500 CreatorName Ogi, Hirotsugu
	CreatorName Matsumoto, Kozo
	CreatorName Fujita, Yusaku
	CreatorName Kawamoto, Tetsuya
	NRID 1000050452404 1000050452404 researchmap permalink nnakamura nnakamura Scopus Author ID 7403356186 7403356186 ORCID 0000-0002-5338-842X 0000-0002-5338-842X CreatorName Nakamura, Nobutomo
	NRID 1000080112027 1000080112027 CreatorName Hirao, Masahiko
Description	Hirotsugu Ogi, Kozo Matsumoto, Yusaku Fujita, Tetsuya Kawamoto, Nobutomo Nakamura and Masahiko Hirao. Label-free ultrathin Pt film biosensor using phonon vibrations excited by ultrafast light pulses. Applied Physics Express, 2010, 3(1), 017001. https://doi.org/10.1143/APEX.3.017001.
Abstract	An ultrathin film oscillator biosensor is presented for highly sensitive monitoring of binding reactions among biomolecules in solutions. The phonon vibration along the thickness direction of an 18-nm Pt film is measured by ultrafast light pulses, whose fundamental resonance frequency is 120 GHz. The vibrational amplitude is monitored during binding reaction between human immunoglobulin G (hIgG) and anti-hIgG antibody, which exponentially decreases as the reaction progresses. A 6 pM hIgG solution can be detected. This biosensor also shows the ability to determine the affinity between proteins through the concentration dependence of the reaction rate.
Publisher	The Japan Society of Applied Physics
Source Title	Applied Physics Express
Volume (Issue)	3(1)
Page	017001
Date of Issued	2009-12-25
Language	English
Handle URL	https://hdl.handle.net/11094/84154
PISSN	18820778
eISSN	18820786
NCID	AA12295133
Relation.isVersionOf	DOI (Publisher Version) https://doi.org/10.1143/APEX.3.017001
Access Rights	open access
oaire:version	Accepted Manuscript
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCMI Type	Text
DCTERMS.bibliographicCitation	Applied Physics Express. 2009, 3(1), p. 017001
DC.title	Label-free ultrathin Pt film biosensor using phonon vibrations excited by ultrafast light pulses
DC.creator	Ogi, Hirotsugu
	Matsumoto, Kozo
	Fujita, Yusaku
	Kawamoto, Tetsuya
	Nakamura, Nobutomo
	Hirao, Masahiko
DC.publisher	The Japan Society of Applied Physics
DC.language' scheme='DCTERMS.RFC1766	English
DC.type' scheme='DCTERMS.DCMIType	Text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2009-12-25
DC.identifier	https://doi.org/10.1143/APEX.3.017001
DC.description	Hirotsugu Ogi, Kozo Matsumoto, Yusaku Fujita, Tetsuya Kawamoto, Nobutomo Nakamura and Masahiko Hirao. Label-free ultrathin Pt film biosensor using phonon vibrations excited by ultrafast light pulses. Applied Physics Express, 2010, 3(1), 017001. https://doi.org/10.1143/APEX.3.017001.
DCTERMS.abstract	An ultrathin film oscillator biosensor is presented for highly sensitive monitoring of binding reactions among biomolecules in solutions. The phonon vibration along the thickness direction of an 18-nm Pt film is measured by ultrafast light pulses, whose fundamental resonance frequency is 120 GHz. The vibrational amplitude is monitored during binding reaction between human immunoglobulin G (hIgG) and anti-hIgG antibody, which exponentially decreases as the reaction progresses. A 6 pM hIgG solution can be detected. This biosensor also shows the ability to determine the affinity between proteins through the concentration dependence of the reaction rate.
DC.format	84154
citation_title	Label-free ultrathin Pt film biosensor using phonon vibrations excited by ultrafast light pulses
citation_author	Ogi, Hirotsugu
	Matsumoto, Kozo
	Fujita, Yusaku
	Kawamoto, Tetsuya
	Nakamura, Nobutomo
	Hirao, Masahiko
citation_publisher	The Japan Society of Applied Physics
citation_language	English
citation_date	2009-12-25
citation_journal_title	Applied Physics Express
citation_volume	3
citation_issue	1
citation_firstpage	017001
citation_doi	https://doi.org/10.1143/APEX.3.017001
citation_public_url	https://hdl.handle.net/11094/84154

Label-free ultrathin Pt film biosensor using phonon vibrations excited by ultrafast light pulses

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