High-frequency wireless and electrodeless quartz crystal microbalance developed as immunosensor

Ogi, Hirotsugu; Motohisa, Kazuma; Hatanaka, Kenichi; Ohmori, Toshinobu; Hirao, Masahiko; Nlshiyama, Masayoshi

doi:https://doi.org/10.1143/JJAP.46.4693

High-frequency wireless and electrodeless quartz crystal microbalance developed as immunosensor

Ogi, Hirotsugu; Motohisa, Kazuma; Hatanaka, Kenichi et al.

Japanese Journal of Applied Physics, 2007, 46, 4693-4697

Number of Access:308（2025-08-23 22:41 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/84160

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Title	High-frequency wireless and electrodeless quartz crystal microbalance developed as immunosensor
Creator	NRID 1000090252626 1000090252626 researchmap permalink read0042771 read0042771 Scopus Author ID 35563683500 35563683500 CreatorName Ogi, Hirotsugu
	CreatorName Motohisa, Kazuma
	CreatorName Hatanaka, Kenichi
	CreatorName Ohmori, Toshinobu
	NRID 1000080112027 1000080112027 CreatorName Hirao, Masahiko
	CreatorName Nlshiyama, Masayoshi
Subject	QCM
	Biosensor
	Wireless
	Electrodeless
Description	Hirotsugu Ogi, Kazuma Motohisa, Kenichi Hatanaka, Toshinobu Ohmori, Masahiko Hirao and Masayoshi Nishiyama. High-frequency wireless and electrodeless quartz crystal microbalance developed as immunosensor. Japanese Journal of Applied Physics, 2007, 46(7S), 4693. https://doi.org/10.1143/JJAP.46.4693.
Abstract	A wireless and electrodeless high-frequency quartz crystal microbalance (QCM) was developed for monitoring biochemical reactions in real time without using any labeling procedures. An analytical vibrational calculation for a multilayered plate showed that the QCM sensitivity significantly deteriorates when metallic electrodes are present on the crystal surfaces, indicating the importance of an electrodeless QCM biosensor. The 30-μm-thick electrodeless QCM immunosensor was excited, and its mechanical vibration was detected contactlessly using an antenna located outside the QCM cells. The homebuilt QCM system was used to detect human immunoglobulin G (hIgG) using staphylococcal protein A (SPA) immobilized on the crystal surface and to demonstrate the higher sensitivity of the electrodeless QCM than that of the conventional QCM. The 30-μm-thick QCM, with a 54MHz fundamental frequency, successfully monitored the hlgG-SPA binding reaction for a hIgG concentration of 100pg/mL.
Publisher	The Japan Society of Applied Physics
Source Title	Japanese Journal of Applied Physics
Volume (Issue)	46
Page	4693-4697
Date of Issued	2007-07-26
Language	English
Handle URL	https://hdl.handle.net/11094/84160
PISSN	00214922
eISSN	13474065
NCID	AA10457675
Relation.isVersionOf	DOI (Publisher Version) https://doi.org/10.1143/JJAP.46.4693
Access Rights	open access
oaire:version	Accepted Manuscript
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCMI Type	Text
DCTERMS.bibliographicCitation	Japanese Journal of Applied Physics. 2007, 46, p. 4693-4697
DC.title	High-frequency wireless and electrodeless quartz crystal microbalance developed as immunosensor
DC.creator	Ogi, Hirotsugu
	Motohisa, Kazuma
	Hatanaka, Kenichi
	Ohmori, Toshinobu
	Hirao, Masahiko
	Nlshiyama, Masayoshi
DC.publisher	The Japan Society of Applied Physics
DC.language' scheme='DCTERMS.RFC1766	English
DC.type' scheme='DCTERMS.DCMIType	Text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2007-07-26
DC.identifier	https://doi.org/10.1143/JJAP.46.4693
DC.subject	QCM
	Biosensor
	Wireless
	Electrodeless
DC.description	Hirotsugu Ogi, Kazuma Motohisa, Kenichi Hatanaka, Toshinobu Ohmori, Masahiko Hirao and Masayoshi Nishiyama. High-frequency wireless and electrodeless quartz crystal microbalance developed as immunosensor. Japanese Journal of Applied Physics, 2007, 46(7S), 4693. https://doi.org/10.1143/JJAP.46.4693.
DCTERMS.abstract	A wireless and electrodeless high-frequency quartz crystal microbalance (QCM) was developed for monitoring biochemical reactions in real time without using any labeling procedures. An analytical vibrational calculation for a multilayered plate showed that the QCM sensitivity significantly deteriorates when metallic electrodes are present on the crystal surfaces, indicating the importance of an electrodeless QCM biosensor. The 30-μm-thick electrodeless QCM immunosensor was excited, and its mechanical vibration was detected contactlessly using an antenna located outside the QCM cells. The homebuilt QCM system was used to detect human immunoglobulin G (hIgG) using staphylococcal protein A (SPA) immobilized on the crystal surface and to demonstrate the higher sensitivity of the electrodeless QCM than that of the conventional QCM. The 30-μm-thick QCM, with a 54MHz fundamental frequency, successfully monitored the hlgG-SPA binding reaction for a hIgG concentration of 100pg/mL.
DC.format	84160
citation_title	High-frequency wireless and electrodeless quartz crystal microbalance developed as immunosensor
citation_author	Ogi, Hirotsugu
	Motohisa, Kazuma
	Hatanaka, Kenichi
	Ohmori, Toshinobu
	Hirao, Masahiko
	Nlshiyama, Masayoshi
citation_publisher	The Japan Society of Applied Physics
citation_language	English
citation_date	2007-07-26
citation_journal_title	Japanese Journal of Applied Physics
citation_volume	46
citation_firstpage	4693
citation_lastpage	4697
citation_doi	https://doi.org/10.1143/JJAP.46.4693
citation_public_url	https://hdl.handle.net/11094/84160

High-frequency wireless and electrodeless quartz crystal microbalance developed as immunosensor

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