Detection of glypiean-3 proteins for hepatocellular carcinoma marker using wireless-electrodeless quartz-crystal microbalance

Ogi, Hirotsugu; Omori, Toshinobu; Hatanaka, Kenichi et al.

Japanese Journal of Applied Physics, 2008, 47, 4021-4023

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Identifier to cite or link to this item: https://hdl.handle.net/11094/84161

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Title
Detection of glypiean-3 proteins for hepatocellular carcinoma marker using wireless-electrodeless quartz-crystal microbalance
Creator
NRID
1000090252626 1000090252626
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Scopus Author ID
35563683500 35563683500
CreatorName
Ogi, Hirotsugu
CreatorName
Omori, Toshinobu
CreatorName
Hatanaka, Kenichi
NRID
1000080112027 1000080112027
CreatorName
Hirao, Masahiko
CreatorName
Nishiyama, Masayoshi
Subject
QCM
Biosensor
Glypican-3
Wireless
Electrodeless
Description
Hirotsugu Ogi, Toshinobu Omori, Kenichi Hatanaka, Masahiko Hirao and Masayoshi Nishiyama. Detection of glypiean-3 proteins for hepatocellular carcinoma marker using wireless-electrodeless quartz-crystal microbalance. Japanese Journal of Applied Physics, 2008, 47(5S), 4021. https://doi.org/10.1143/JJAP.47.4021.
Abstract
Pure shear-wave resonances were excited and detected in 18- and 30-μm-thick electrodeless AT-cut quartz plates in liquids using line antennas contactlessly, achieving high-frequency quartz-crystal microbalances (QCMs). Their fundamental resonance frequencies (85 and 54 MHz) were monitored to study interactions in real time between human glypican-3 and an anti-glypican-3 antibody: glypican-3 is a prospective protein marker for hepatocellular carcinoma. Their affinity was determined by the Langmuir kinetics. This study demonstrates the high ability of the wireless-electrodeless QCM for detection of the protein markers and development of drugs for disorders.
Publisher
The Japan Society of Applied Physics
Source Title
Japanese Journal of Applied Physics
Volume (Issue)
47
Page
4021-4023
Date of Issued
2008-05-23
Language
English
Handle URL
https://hdl.handle.net/11094/84161
PISSN
00214922
eISSN
13474065
NCID
AA12295836
Relation.isVersionOf
DOI (Publisher Version)
https://doi.org/10.1143/JJAP.47.4021
Access Rights
open access
oaire:version
Accepted Manuscript
Category
学術雑誌論文 Journal Article