Sensitive label-free immunoglobulin G detection using a MEMS quartz crystal microbalance biosensor with a 125 MHz wireless quartz resonator

Zhou, Lianjie; Kato, Fumihito; Ogi, Hirotsugu

Japanese Journal of Applied Physics, 2021, 60, SDDB03

Number of Access:422（2025-11-25 02:20 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/84167

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Title
Sensitive label-free immunoglobulin G detection using a MEMS quartz crystal microbalance biosensor with a 125 MHz wireless quartz resonator
Creator
CreatorName
Zhou, Lianjie
NRID
1000070780170 1000070780170
CreatorName
Kato, Fumihito
NRID
1000090252626 1000090252626
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Scopus Author ID
35563683500 35563683500
ORCID
0000-0002-9602-5194 0000-0002-9602-5194
CreatorName
Ogi, Hirotsugu
Description
This is the Accepted Manuscript version of an article accepted for publication in Japanese Journal of Applied Physics. IOP Publishing Ltd are not responsible for any errors or omissions in this version of the manuscript or any version derived from it. The Version of Record is available online at https://doi.org/10.35848/1347-4065/abea50.
Abstract
We present a wireless quartz crystal microbalance (QCM) biosensor fabricated using MEMS technology. The MEMS QCM biosensor contains a 125 MHz AT-cut quartz resonator embedded in the microchannel. Because of the compact design, the MEMS QCM biosensor is suitable for mass production and device miniaturization. We performed immunoglobulin G (IgG) detection measurements with different concentrations of IgG. The detection limit was 1 ng ml-1 or less, which is superior to that of the gold-standard surface plasma resonance method. Furthermore, we studied the binding affinity between protein A and IgG by studying the frequency response of the QCM biosensor. We found good agreement with reported values. Therefore, the presented MEMS QCM biosensor has the advantages of compactness, low cost, low power consumption, high sensitivity, and reliability.
Publisher
The Japan Society of Applied Physics
Source Title
Japanese Journal of Applied Physics
Volume (Issue)
60
Page
SDDB03
Date of Issued
2021-03-29
Language
English
Handle URL
https://hdl.handle.net/11094/84167
PISSN
00214922
eISSN
13474065
NCID
AA12295836
Relation.isVersionOf
DOI (Publisher Version)
https://doi.org/10.35848/1347-4065/abea50
Access Rights
open access
CopyRight
© 2021 The Japan Society of Applied Physics. This Accepted Manuscript is available for reuse under a CC BY-NC-ND licence after the 12 month embargo period provided that all the terms of the licence are adhered to.
oaire:version
Accepted Manuscript
Category
学術雑誌論文 Journal Article