A Bio-synthetic Hybrid Hydrogel Formed under Physiological Conditions Consisting of Mucin and a Synthetic Polymer Carrying Boronic Acid

Nakahata, Masaki; Tominaga, Naoki; Saito, Keishi et al.

Macromolecular Bioscience, 2022, 22(6), 2200055

Number of Access:884（2025-08-26 11:38 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/88315

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Title
A Bio-synthetic Hybrid Hydrogel Formed under Physiological Conditions Consisting of Mucin and a Synthetic Polymer Carrying Boronic Acid
Creator
NRID
1000040755641 1000040755641
ORCID
0000-0003-0397-5922 0000-0003-0397-5922
researchmap permalink
masakinakahata masakinakahata
Scopus Author ID
54397448600 54397448600
CreatorName
Nakahata, Masaki
CreatorName
Tominaga, Naoki
CreatorName
Saito, Keishi
NRID
1000040756029 1000040756029
CreatorName
Nishiyama, Keita
CreatorName
Tanino, Yuya
CreatorName
Saiki, Kiyoshiro
NRID
1000000533647 1000000533647
researchmap permalink
KJM_MSR KJM_MSR
Scopus Author ID
55142751800 55142751800
CreatorName
Kojima, Masaru
NRID
1000020359938 1000020359938
ORCID
0000-0002-1041-4798 0000-0002-1041-4798
researchmap permalink
sakaishinji sakaishinji
Scopus Author ID
35450082900 35450082900
CreatorName
Sakai, Shinji
Subject
bio-synthetic hybrid materials
boronic acid
hydrogel
mucin
reversible bonds
Description
This is the peer reviewed version of the following article: Nakahata, M., Tominaga, N., Saito, K., Nishiyama, K., Tanino, Y., Saiki, K., Kojima, M. and Sakai, S. (2022), A Bio-synthetic Hybrid Hydrogel Formed under Physiological Conditions Consisting of Mucin and a Synthetic Polymer Carrying Boronic Acid. Macromol. Biosci., 22: 2200055, which has been published in final form at https://doi.org/10.1002/mabi.202200055. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.
Abstract
Mucin-containing bio-synthetic hybrid hydrogel is successfully formed under physiological conditions upon mixing aqueous solutions of native mucin and synthetic polymers carrying boronic acids. The mechanical properties and stability of the hydrogel in physiological solutions, e.g., cell culture media, are tunable depending on the boronic acid content of polymers. The hydrogel dissolved in the physiological solutions releases native mucin and boronic acid-containing polymer, which can control the adhesion of mammalian cells to the surface.
Publisher
John Wiley and Sons
Source Title
Macromolecular Bioscience
Volume (Issue)
22(6)
Page
2200055
Date of Issued
2022-06-01
Language
English
Handle URL
https://hdl.handle.net/11094/88315
PISSN
16165187
eISSN
16165195
Relation.isVersionOf
DOI (Publisher Version)
https://doi.org/10.1002/mabi.202200055
Relation.isIdenticalTo
PMID
35429097
Access Rights
open access
CopyRight
© 2022 Wiley-VCH GmbH
oaire:version
Accepted Manuscript
Category
学術雑誌論文 Journal Article