Development of a mesoscopic framework spanning nanoscale protofibril dynamics to macro-scale fibrin clot formation

Takeishi, Naoki; Shigematsu, Taiki; Enosaki, Ryogo; Ishida, Shunichi; Ii, Satoshi; Wada, Shigeo

doi:https://doi.org/10.1098/rsif.2021.0554

Development of a mesoscopic framework spanning nanoscale protofibril dynamics to macro-scale fibrin clot formation

Takeishi, Naoki; Shigematsu, Taiki; Enosaki, Ryogo et al.

Journal of the Royal Society Interface, 2021, 18(184), 20210554

Number of Access:848（2025-08-28 20:55 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/88626

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Title	Development of a mesoscopic framework spanning nanoscale protofibril dynamics to macro-scale fibrin clot formation
Creator	NRID 1000030787669 1000030787669 ORCID 0000-0002-9568-8711 0000-0002-9568-8711 researchmap permalink ntakeishi ntakeishi Scopus Author ID 55180234600 55180234600 CreatorName Takeishi, Naoki
	NRID 1000050775765 1000050775765 researchmap permalink shigematsu_1990 shigematsu_1990 Scopus Author ID 56195177700 56195177700 CreatorName Shigematsu, Taiki
	CreatorName Enosaki, Ryogo
	NRID 1000080824169 1000080824169 CreatorName Ishida, Shunichi
	NRID 1000050513016 1000050513016 CreatorName Ii, Satoshi
	NRID 1000070240546 1000070240546 researchmap permalink shigeo41010 shigeo41010 Scopus Author ID 7401983636 7401983636 CreatorName Wada, Shigeo
Subject	computational modelling
	fibrin clot
	mesoscopic dynamics
	protofibril
Description	Takeishi Naoki, Shigematsu Taiki, Enosaki Ryogo, Ishida Shunichi, Ii Satoshi and Wada Shigeo 2021Development of a mesoscopic framework spanning nanoscale protofibril dynamics to macro-scale fibrin clot formationJ. R. Soc. Interface.182021055420210554 http://doi.org/10.1098/rsif.2021.0554
Abstract	Thrombi form a micro-scale fibrin network consisting of an interlinked structure of nanoscale protofibrils, resulting in haemostasis. It is theorized that the mechanical effect of the fibrin clot is caused by the polymeric protofibrils between crosslinks, or to their dynamics on a nanoscale order. Despite a number of studies, however, it is still unknown, how the nanoscale protofibril dynamics affect the formation of the macro-scale fibrin clot and thus its mechanical properties. A mesoscopic framework would be useful to tackle this multi-scale problem, but it has not yet been established. We thus propose a minimal mesoscopic model for protofibrils based on Brownian dynamics, and performed numerical simulations of protofibril aggregation. We also performed stretch tests of polymeric protofibrils to quantify the elasticity of fibrin clots. Our model results successfully captured the conformational properties of aggregated protofibrils, e.g., strain-hardening response. Furthermore, the results suggest that the bending stiffness of individual protofibrils increases to resist extension.
Publisher	Royal Society Publishing
Source Title	Journal of the Royal Society Interface
Volume (Issue)	18(184)
Page	20210554
Date of Issued	2021-11-10
Language	English
Handle URL	https://hdl.handle.net/11094/88626
PISSN	17425689
eISSN	17425662
NCID	AA12061165
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1098/rsif.2021.0554
Relation.isIdenticalTo	PMID 34753310
Access Rights	open access
CopyRight	This article is licensed under a Creative Commons Attribution 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCMI Type	Text
DCTERMS.bibliographicCitation	Journal of the Royal Society Interface. 2021, 18(184), p. 20210554
DC.title	Development of a mesoscopic framework spanning nanoscale protofibril dynamics to macro-scale fibrin clot formation
DC.creator	Takeishi, Naoki
	Shigematsu, Taiki
	Enosaki, Ryogo
	Ishida, Shunichi
	Ii, Satoshi
	Wada, Shigeo
DC.publisher	Royal Society Publishing
DC.language' scheme='DCTERMS.RFC1766	English
DC.type' scheme='DCTERMS.DCMIType	Text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2021-11-10
DC.identifier	https://doi.org/10.1098/rsif.2021.0554
DC.subject	computational modelling
	fibrin clot
	mesoscopic dynamics
	protofibril
DC.description	Takeishi Naoki, Shigematsu Taiki, Enosaki Ryogo, Ishida Shunichi, Ii Satoshi and Wada Shigeo 2021Development of a mesoscopic framework spanning nanoscale protofibril dynamics to macro-scale fibrin clot formationJ. R. Soc. Interface.182021055420210554 http://doi.org/10.1098/rsif.2021.0554
DCTERMS.abstract	Thrombi form a micro-scale fibrin network consisting of an interlinked structure of nanoscale protofibrils, resulting in haemostasis. It is theorized that the mechanical effect of the fibrin clot is caused by the polymeric protofibrils between crosslinks, or to their dynamics on a nanoscale order. Despite a number of studies, however, it is still unknown, how the nanoscale protofibril dynamics affect the formation of the macro-scale fibrin clot and thus its mechanical properties. A mesoscopic framework would be useful to tackle this multi-scale problem, but it has not yet been established. We thus propose a minimal mesoscopic model for protofibrils based on Brownian dynamics, and performed numerical simulations of protofibril aggregation. We also performed stretch tests of polymeric protofibrils to quantify the elasticity of fibrin clots. Our model results successfully captured the conformational properties of aggregated protofibrils, e.g., strain-hardening response. Furthermore, the results suggest that the bending stiffness of individual protofibrils increases to resist extension.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	88626
citation_title	Development of a mesoscopic framework spanning nanoscale protofibril dynamics to macro-scale fibrin clot formation
citation_author	Takeishi, Naoki
	Shigematsu, Taiki
	Enosaki, Ryogo
	Ishida, Shunichi
	Ii, Satoshi
	Wada, Shigeo
citation_publisher	Royal Society Publishing
citation_language	English
citation_date	2021-11-10
citation_journal_title	Journal of the Royal Society Interface
citation_volume	18
citation_issue	184
citation_firstpage	20210554
citation_doi	https://doi.org/10.1098/rsif.2021.0554
citation_pmid	34753310
citation_public_url	https://hdl.handle.net/11094/88626

Development of a mesoscopic framework spanning nanoscale protofibril dynamics to macro-scale fibrin clot formation

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