Deformation of a red blood cell in a narrow rectangular microchannel

Takeishi, Naoki; Ito, Hiroaki; Kaneko, Makoto; Wada, Shigeo

doi:https://doi.org/10.3390/mi10030199

Deformation of a red blood cell in a narrow rectangular microchannel

Takeishi, Naoki; Ito, Hiroaki; Kaneko, Makoto et al.

Micromachines, 2019, 10(3), 199

Number of Access:668（2025-08-28 20:54 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/88656

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Title	Deformation of a red blood cell in a narrow rectangular microchannel
Creator	NRID 1000030787669 1000030787669 ORCID 0000-0002-9568-8711 0000-0002-9568-8711 researchmap permalink ntakeishi ntakeishi Scopus Author ID 55180234600 55180234600 CreatorName Takeishi, Naoki
	NRID 1000010783186 1000010783186 CreatorName Ito, Hiroaki
	NRID 1000070224607 1000070224607 CreatorName Kaneko, Makoto
	NRID 1000070240546 1000070240546 researchmap permalink shigeo41010 shigeo41010 Scopus Author ID 7401983636 7401983636 CreatorName Wada, Shigeo
Subject	Computational biomechanics
	Finite element method
	Immersed boundary method
	Lattice-Boltzmann method
	Narrow rectangular microchannel
	Red blood cells
Description	Takeishi, Naoki, Hiroaki Ito, Makoto Kaneko, and Shigeo Wada. 2019. "Deformation of a Red Blood Cell in a Narrow Rectangular Microchannel" Micromachines 10, no. 3: 199. https://doi.org/10.3390/mi10030199
Abstract	The deformability of a red blood cell (RBC) is one of the most important biological parameters affecting blood flow, both in large arteries and in the microcirculation, and hence it can be used to quantify the cell state. Despite numerous studies on the mechanical properties of RBCs, including cell rigidity, much is still unknown about the relationship between deformability and the configuration of flowing cells, especially in a confined rectangular channel. Recent computer simulation techniques have successfully been used to investigate the detailed behavior of RBCs in a channel, but the dynamics of a translating RBC in a narrow rectangular microchannel have not yet been fully understood. In this study, we numerically investigated the behavior of RBCs flowing at different velocities in a narrow rectangular microchannel that mimicked a microfluidic device. The problem is characterized by the capillary number Ca, which is the ratio between the fluid viscous force and the membrane elastic force. We found that confined RBCs in a narrow rectangular microchannel maintained a nearly unchanged biconcave shape at low Ca, then assumed an asymmetrical slipper shape at moderate Ca, and finally attained a symmetrical parachute shape at high Ca. Once a RBC deformed into one of these shapes, it was maintained as the final stable configurations. Since the slipper shape was only found at moderate Ca, measuring configurations of flowing cells will be helpful to quantify the cell state.
Publisher	MDPI
Source Title	Micromachines
Volume (Issue)	10(3)
Page	199
Date of Issued	2019-03-21
Language	English
Handle URL	https://hdl.handle.net/11094/88656
eISSN	2072666X
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.3390/mi10030199
Access Rights	open access
CopyRight	This article is licensed under a Creative Commons Attribution 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCMI Type	Text
DCTERMS.bibliographicCitation	Micromachines. 2019, 10(3), p. 199
DC.title	Deformation of a red blood cell in a narrow rectangular microchannel
DC.creator	Takeishi, Naoki
	Ito, Hiroaki
	Kaneko, Makoto
	Wada, Shigeo
DC.publisher	MDPI
DC.language' scheme='DCTERMS.RFC1766	English
DC.type' scheme='DCTERMS.DCMIType	Text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2019-03-21
DC.identifier	https://doi.org/10.3390/mi10030199
DC.subject	Computational biomechanics
	Finite element method
	Immersed boundary method
	Lattice-Boltzmann method
	Narrow rectangular microchannel
	Red blood cells
DC.description	Takeishi, Naoki, Hiroaki Ito, Makoto Kaneko, and Shigeo Wada. 2019. "Deformation of a Red Blood Cell in a Narrow Rectangular Microchannel" Micromachines 10, no. 3: 199. https://doi.org/10.3390/mi10030199
DCTERMS.abstract	The deformability of a red blood cell (RBC) is one of the most important biological parameters affecting blood flow, both in large arteries and in the microcirculation, and hence it can be used to quantify the cell state. Despite numerous studies on the mechanical properties of RBCs, including cell rigidity, much is still unknown about the relationship between deformability and the configuration of flowing cells, especially in a confined rectangular channel. Recent computer simulation techniques have successfully been used to investigate the detailed behavior of RBCs in a channel, but the dynamics of a translating RBC in a narrow rectangular microchannel have not yet been fully understood. In this study, we numerically investigated the behavior of RBCs flowing at different velocities in a narrow rectangular microchannel that mimicked a microfluidic device. The problem is characterized by the capillary number Ca, which is the ratio between the fluid viscous force and the membrane elastic force. We found that confined RBCs in a narrow rectangular microchannel maintained a nearly unchanged biconcave shape at low Ca, then assumed an asymmetrical slipper shape at moderate Ca, and finally attained a symmetrical parachute shape at high Ca. Once a RBC deformed into one of these shapes, it was maintained as the final stable configurations. Since the slipper shape was only found at moderate Ca, measuring configurations of flowing cells will be helpful to quantify the cell state.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	88656
citation_title	Deformation of a red blood cell in a narrow rectangular microchannel
citation_author	Takeishi, Naoki
	Ito, Hiroaki
	Kaneko, Makoto
	Wada, Shigeo
citation_publisher	MDPI
citation_language	English
citation_date	2019-03-21
citation_journal_title	Micromachines
citation_volume	10
citation_issue	3
citation_firstpage	199
citation_doi	https://doi.org/10.3390/mi10030199
citation_public_url	https://hdl.handle.net/11094/88656

Deformation of a red blood cell in a narrow rectangular microchannel

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