Green Oxidation of Indoles Using Molecular Oxygen over a Copper Nitride Nanocube Catalyst

Xu, Hang; Yamaguchi, Sho; Mitsudome, Takato et al.

European Journal of Organic Chemistry, 2022, 2022(30), e202200826

Number of Access:809（2025-08-15 22:51 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/89383

Link to primary information 

File Format Terms of use Size Views Date.Available Description information
EurJOC_e202200826 pdf None 596 KB 127 2023.08.12  

Item Information

Output File Export EndNote Basic Export Mendeley

Title
Green Oxidation of Indoles Using Molecular Oxygen over a Copper Nitride Nanocube Catalyst
Creator
CreatorName
Xu, Hang
NRID
1000050700150 1000050700150
researchmap permalink
7000018077 7000018077
Scopus Author ID
56424690000 56424690000
CreatorName
Yamaguchi, Sho
NRID
1000000437360 1000000437360
ORCID
0000-0003-3071-8243 0000-0003-3071-8243
researchmap permalink
read0107411 read0107411
Scopus Author ID
11240122700 11240122700
CreatorName
Mitsudome, Takato
NRID
1000050314406 1000050314406
ORCID
0000-0001-5701-7530 0000-0001-5701-7530
researchmap permalink
read0054694 read0054694
Scopus Author ID
7003481890 7003481890
CreatorName
Mizugaki, Tomoo
Subject
Indoles
Molecular oxygen
Nanocube
Trimerization
Witkop oxidation
Description
H. Xu, S. Yamaguchi, T. Mitsudome, T. Mizugaki, Eur. J. Org. Chem. 2022, e202200826.
Abstract
Oxidative transformation of indoles is a promising approach for synthesizing valuable nitrogen-containing compounds; however, conventional methods use toxic oxidants and additives. Herein, we report for the first time the catalytic oxidative trimerization and the oxygenative cleavage (Witkop oxidation) of indoles using molecular oxygen under additive-free conditions accomplished by a copper nitride nanocube (Cu3N NC) catalyst. The Cu3N NC catalyst exhibits excellent activity to produce various indolin-3-ones and 2-ketoanilides with high functional group tolerance. Owing to this excellent catalytic performance, the Cu3N NC catalyst is distinguished from the conventional copper catalysts, demonstrating the high catalytic potential of metal nitride in organic synthesis.
Publisher
Wiley-VCH GmbH
Source Title
European Journal of Organic Chemistry
Volume (Issue)
2022(30)
Page
e202200826
Date of Issued
2022-08-12
Language
English
Handle URL
https://hdl.handle.net/11094/89383
PISSN
1434193X
eISSN
10990690
NCID
AA1118165X
Relation.isVersionOf
DOI (Publisher Version)
https://doi.org/10.1002/ejoc.202200826
Access Rights
open access
CopyRight
© 2022 Wiley-VCH GmbH
oaire:version
Accepted Manuscript
Category
学術雑誌論文 Journal Article