Young Age, Female Sex, and No Comorbidities Are Risk Factors for Adverse Reactions after the Third Dose of BNT162b2 COVID-19 Vaccine against SARS-CoV-2: A Prospective Cohort Study in Japan

Urakawa, Ryuta; Isomura, Emiko; Matsunaga, Kazuhide et al.

Vaccines, 2022, 10(8), 1357

Number of Access:660（2025-09-13 18:42 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/89685

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Title
Young Age, Female Sex, and No Comorbidities Are Risk Factors for Adverse Reactions after the Third Dose of BNT162b2 COVID-19 Vaccine against SARS-CoV-2: A Prospective Cohort Study in Japan
Creator
CreatorName
Urakawa, Ryuta
NRID
1000070397701 1000070397701
researchmap permalink
read0076452 read0076452
Scopus Author ID
55667115400 55667115400
ORCID
0000-0002-7855-9600 0000-0002-7855-9600
CreatorName
Isomura, Emiko
Creator.Alternative
Tanaka, Emiko
NRID
1000080368323 1000080368323
researchmap permalink
kazuhide kazuhide
Scopus Author ID
7202702921 7202702921
ORCID
0009-0006-7170-2757 0009-0006-7170-2757
CreatorName
Matsunaga, Kazuhide
NRID
1000050728946 1000050728946
CreatorName
Kubota, Kazumi
Subject
adverse event
booster
infectious disease
side effect
vaccination interval
Description
Urakawa R., Isomura E.T., Matsunaga K., et al. Young Age, Female Sex, and No Comorbidities Are Risk Factors for Adverse Reactions after the Third Dose of BNT162b2 COVID-19 Vaccine against SARS-CoV-2: A Prospective Cohort Study in Japan. Vaccines, 10, 8, 1357. https://doi.org/https://doi.org/10.3390/vaccines10081357.
Abstract
Background: This study compared the adverse events (AEs) of the second and third doses of BNT162b2, as well as investigated the impact of vaccine recipients’ background and vaccination interval on the AEs of the third dose. Methods: We conducted a questionnaire survey of AEs among health care workers at Osaka University Dental Hospital. Chi-square tests were performed to compare AEs to the administration of second and third vaccine doses. Logistic regression analyses were conducted to identify factors influencing the presence of AEs using age, sex, comorbidities, and the vaccination interval. Spearman’s rank correlation coefficient was calculated to investigate the correlation between age, vaccination interval, and severity of each AE. Results: The third dose of BNT162b2 was associated with significantly more frequent or milder AEs than the second dose. Logistic regression analyses detected significant differences in six items of AEs by age, three by sex, two by comorbidities, and zero by vaccination interval. Consistently, the risk of AEs was greater among younger persons, females, and those without comorbidities. Significant negative correlations were detected between age and vaccination interval, and between age and the severity of most AEs. Conclusions: Young, female, and having no comorbidities are risk factors for AEs after the third dose of BNT162b2, while vaccination interval is not.
Publisher
MDPI
Source Title
Vaccines
Volume (Issue)
10(8)
Page
1357
Date of Issued
2022-08
Language
English
Handle URL
https://hdl.handle.net/11094/89685
eISSN
2076393X
Relation.isIdenticalTo
DOI (Publisher Version)
https://doi.org/10.3390/vaccines10081357
Access Rights
open access
CopyRight
This article is licensed under a Creative Commons Attribution 4.0 International License.
oaire:version
Version of Record
Category
学術雑誌論文 Journal Article