Evaluation of sites of velopharyngeal structure augmentation in dogs for improvement of velopharyngeal insufficiency

Isomura, Emiko; Nakagawa, Kiyoko; Matsukawa, Makoto et al.

PLoS ONE, 2019, 14(2), e0212752

Number of Access:734（2025-09-13 18:41 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/89689

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Title
Evaluation of sites of velopharyngeal structure augmentation in dogs for improvement of velopharyngeal insufficiency
Creator
NRID
1000070397701 1000070397701
researchmap permalink
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Scopus Author ID
55667115400 55667115400
ORCID
0000-0002-7855-9600 0000-0002-7855-9600
CreatorName
Isomura, Emiko
Creator.Alternative
Tanaka, Emiko
NRID
1000070827419 1000070827419
CreatorName
Nakagawa, Kiyoko
NRID
1000070845859 1000070845859
CreatorName
Matsukawa, Makoto
CreatorName
Mitsui, Ryou
NRID
1000020205371 1000020205371
CreatorName
Kogo, Mikihiko
Description
Evaluation of sites of velopharyngeal structure augmentation in dogs for improvement of velopharyngeal insufficiency. Isomura ET, Nakagawa K, Matsukawa M, Mitsui R, Kogo M. PLOS ONE. 2019. 14(2) e0212752. doi:10.1371/journal.pone.0212752
Abstract
Background Velopharyngeal structure augmentation methods are used as alternatives to velopharyngeal plasty. Anatomic sites of implantation/injection vary widely due to a lack of standardized criteria. Here, we experimentally investigated optimal sites of velopharyngeal structure augmentation via saline injection in dogs as they naturally exhibit velopharyngeal insufficiency (VPI). Methods Velopharyngeal structure augmentation was performed on 10 beagles (age range: 20–24 months; weight range: 9–12 kg). Saline containing 1/80,000 epinephrine was injected intraorally in 1-mL increments into the nasal mucosa of the soft palate (n = 4), posterior pharyngeal wall (n = 3), or bilateral pharyngeal walls (n = 3) of each dog. Nasal air leakage was measured under rebreathing until velopharyngeal closure was achieved; the measurement was performed using flow meter sensors on both nasal apertures, and the oral cavity was filled with alginate impression material to prevent oral air leakage. Results Pre-injection, the dogs exhibited an average of 0.455 L/s air leakage from the nasal cavity. The dogs with saline injected into the nasal mucosa of the soft palate achieved steady augmentation, and nasal air leakage disappeared under rebreathing following 6-mL saline injection. Conversely, nasal air leakage remained in the dogs with saline injected in the posterior pharyngeal wall or bilateral pharyngeal walls. Conclusions During VPI treatment in dogs, augmentation was most effective at the nasal mucosa of the soft palate. Improvement in nasal air leakage was highly dependent on the saline injection volume. Although velopharyngeal structures vary between dogs and humans, velopharyngeal closure style is similar. Thus, our results may aid in the treatment of VPI patients.
Publisher
Public Library of Science
Source Title
PLoS ONE
Volume (Issue)
14(2)
Page
e0212752
Date of Issued
2019-02-25
Language
English
Handle URL
https://hdl.handle.net/11094/89689
eISSN
19326203
Relation.isIdenticalTo
DOI (Publisher Version)
https://doi.org/10.1371/journal.pone.0212752
Access Rights
open access
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This article is licensed under a Creative Commons Attribution 4.0 International License.
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Category
学術雑誌論文 Journal Article