Endoscopic soft palate augmentation using injectable materials in dogs to ameliorate velopharyngeal insufficiency

Isomura, Emiko; Matsukawa, Makoto; Nakagawa, Kiyoko; Mitsui, Ryo; Kogo, Mikihiko

doi:https://doi.org/10.1371/journal.pone.0238646

Endoscopic soft palate augmentation using injectable materials in dogs to ameliorate velopharyngeal insufficiency

Isomura, Emiko; Matsukawa, Makoto; Nakagawa, Kiyoko et al.

PLoS ONE, 2020, 15(9), e0238646

Number of Access:707（2025-09-13 18:42 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/89690

Link to primary information

File	Format	Terms of use	Size	Views	Date.Available	Description	information
PLoSONE_15_9_0238646	pdf	None	1.56 MB	86	2022.12.01

Creative Commons : Attribution

Item Information

Output File Export EndNote Basic Export Mendeley

Title	Endoscopic soft palate augmentation using injectable materials in dogs to ameliorate velopharyngeal insufficiency
Creator	NRID 1000070397701 1000070397701 researchmap permalink read0076452 read0076452 Scopus Author ID 55667115400 55667115400 ORCID 0000-0002-7855-9600 0000-0002-7855-9600 CreatorName Isomura, Emiko Creator.Alternative Tanaka, Emiko
	NRID 1000070845859 1000070845859 CreatorName Matsukawa, Makoto
	NRID 1000070827419 1000070827419 CreatorName Nakagawa, Kiyoko
	CreatorName Mitsui, Ryo
	NRID 1000020205371 1000020205371 CreatorName Kogo, Mikihiko
Description	Endoscopic soft palate augmentation using injectable materials in dogs to ameliorate velopharyngeal insufficiency. Isomura ET, Matsukawa M, Nakagawa K, Mitsui R, Kogo M. PLOS ONE. 2020. 15(9) e0238646. doi:10.1371/journal.pone.0238646
Abstract	Background Velopharyngeal structure augmentation methods are used as alternatives to pharyngeal flap operations. Recently, we investigated the sites of velopharyngeal structure augmentation in dogs and reported that the most effective injection location is the soft palate. However, there have been no reports regarding the optimal materials for implantation or injection. In this study, we aimed to investigate the injectable materials used in soft palate augmentation in dogs to ameliorate velopharyngeal insufficiency (VPI). Methods Endoscopic soft palate augmentation (ESPA) was performed in dogs using purified sodium hyaluronate, atelocollagen, or autogenic fat tissue. ESPA is an original technique developed by our group, and this is the first report of its performance. Moreover, we assessed the amount of nasal air leakage during inspiration at rest and during expiration under the rebreathing system at 1, 2, 3, 4, 5, and 6 months after injection of these materials. Results The amount of nasal air leakage during expiration under the rebreathing system was significantly decreased in all dogs injected with the ESPA materials, but neither apnea nor hypopnea was observed. Conclusions We investigated the optimal materials for use in ESPA, such as purified sodium hyaluronate, atelocollagen, or autogenic fat tissue. We found that all of them reduced nasal air leakage and only autogenic fat tissue showed significant histologic differences in dogs at 6 months. This technique may also be useful for the treatment of patients with VPI.
Publisher	Public Library of Science
Source Title	PLoS ONE
Volume (Issue)	15(9)
Page	e0238646
Date of Issued	2020-09-04
Language	English
Handle URL	https://hdl.handle.net/11094/89690
eISSN	19326203
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1371/journal.pone.0238646
Access Rights	open access
CopyRight	This article is licensed under a Creative Commons Attribution 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCMI Type	Text
DCTERMS.bibliographicCitation	PLoS ONE. 2020, 15(9), p. e0238646
DC.title	Endoscopic soft palate augmentation using injectable materials in dogs to ameliorate velopharyngeal insufficiency
DC.creator	Isomura, Emiko
	Matsukawa, Makoto
	Nakagawa, Kiyoko
	Mitsui, Ryo
	Kogo, Mikihiko
DC.creator	Tanaka, Emiko
DC.publisher	Public Library of Science
DC.language' scheme='DCTERMS.RFC1766	English
DC.type' scheme='DCTERMS.DCMIType	Text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2020-09-04
DC.identifier	https://doi.org/10.1371/journal.pone.0238646
DC.description	Endoscopic soft palate augmentation using injectable materials in dogs to ameliorate velopharyngeal insufficiency. Isomura ET, Matsukawa M, Nakagawa K, Mitsui R, Kogo M. PLOS ONE. 2020. 15(9) e0238646. doi:10.1371/journal.pone.0238646
DCTERMS.abstract	Background Velopharyngeal structure augmentation methods are used as alternatives to pharyngeal flap operations. Recently, we investigated the sites of velopharyngeal structure augmentation in dogs and reported that the most effective injection location is the soft palate. However, there have been no reports regarding the optimal materials for implantation or injection. In this study, we aimed to investigate the injectable materials used in soft palate augmentation in dogs to ameliorate velopharyngeal insufficiency (VPI). Methods Endoscopic soft palate augmentation (ESPA) was performed in dogs using purified sodium hyaluronate, atelocollagen, or autogenic fat tissue. ESPA is an original technique developed by our group, and this is the first report of its performance. Moreover, we assessed the amount of nasal air leakage during inspiration at rest and during expiration under the rebreathing system at 1, 2, 3, 4, 5, and 6 months after injection of these materials. Results The amount of nasal air leakage during expiration under the rebreathing system was significantly decreased in all dogs injected with the ESPA materials, but neither apnea nor hypopnea was observed. Conclusions We investigated the optimal materials for use in ESPA, such as purified sodium hyaluronate, atelocollagen, or autogenic fat tissue. We found that all of them reduced nasal air leakage and only autogenic fat tissue showed significant histologic differences in dogs at 6 months. This technique may also be useful for the treatment of patients with VPI.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	89690
citation_title	Endoscopic soft palate augmentation using injectable materials in dogs to ameliorate velopharyngeal insufficiency
citation_author	Isomura, Emiko
	Matsukawa, Makoto
	Nakagawa, Kiyoko
	Mitsui, Ryo
	Kogo, Mikihiko
citation_publisher	Public Library of Science
citation_language	English
citation_date	2020-09-04
citation_journal_title	PLoS ONE
citation_volume	15
citation_issue	9
citation_firstpage	e0238646
citation_doi	https://doi.org/10.1371/journal.pone.0238646
citation_public_url	https://hdl.handle.net/11094/89690

Endoscopic soft palate augmentation using injectable materials in dogs to ameliorate velopharyngeal insufficiency

Link to primary information

Item Information

Show details