Bone fragility via degradation of bone quality featured by collagen/apatite micro-arrangement in human rheumatic arthritis

Ozasa, Ryosuke; Matsugaki, Aira; Ishimoto, Takuya; Kamura, Satoshi; Yoshida, Hiroto; Magi, Mayu; Matsumoto, Yoshihiro; Sakuraba, Koji; Fujimura, Kenjiro; Miyahara, Hisaaki; Nakano, Takayoshi

doi:https://doi.org/10.1016/j.bone.2021.116261

Bone fragility via degradation of bone quality featured by collagen/apatite micro-arrangement in human rheumatic arthritis

Ozasa, Ryosuke; Matsugaki, Aira; Ishimoto, Takuya et al.

Bone, 2022, 155, 116261

Number of Access:968（2025-07-18 10:11 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/89758

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Title	Bone fragility via degradation of bone quality featured by collagen/apatite micro-arrangement in human rheumatic arthritis
Creator	NRID 1000080845347 1000080845347 ORCID 0000-0002-2773-072X 0000-0002-2773-072X researchmap permalink ozasa_r ozasa_r Scopus Author ID 56202812400 56202812400 CreatorName Ozasa, Ryosuke
	NRID 1000010592529 1000010592529 ORCID 0000-0002-8427-7124 0000-0002-8427-7124 researchmap permalink aira aira Scopus Author ID 24172720900 24172720900 CreatorName Matsugaki, Aira
	NRID 1000050508835 1000050508835 ORCID 0000-0003-0081-0591 0000-0003-0081-0591 researchmap permalink i_taku i_taku Scopus Author ID 35310484700 35310484700 CreatorName Ishimoto, Takuya
	CreatorName Kamura, Satoshi
	CreatorName Yoshida, Hiroto
	CreatorName Magi, Mayu
	CreatorName Matsumoto, Yoshihiro
	CreatorName Sakuraba, Koji
	CreatorName Fujimura, Kenjiro
	CreatorName Miyahara, Hisaaki
	NRID 1000030243182 1000030243182 ORCID 0000-0001-8052-1698 0000-0001-8052-1698 researchmap permalink read0013987 read0013987 Scopus Author ID 7403896013 7403896013 CreatorName Nakano, Takayoshi
Subject	Bone quality
	Collagen/apatite orientation
	Fracture risk assessment
	Human knee joint
	Interleukin-6
	Osteocyte
	Rheumatoid arthritis
Description	Ozasa R., Matsugaki A., Ishimoto T., et al. Bone fragility via degradation of bone quality featured by collagen/apatite micro-arrangement in human rheumatic arthritis. Bone, 155, 116261. https://doi.org/10.1016/j.bone.2021.116261.
Abstract	Although increased bone fragility is a well-recognized consequence in patients with rheumatoid arthritis (RA), the essential cause of degenerate bone strength remains unknown. This study aimed to determine factors contributing to bone dysfunction in RA by focusing on the bone matrix micro-arrangement, based on the preferential orientation of collagen and the related apatite c-axis as a bone quality index. The classical understanding of RA is limited to its severe pathological conditions associated with inflammation-induced bone loss. This study examined periarticular proximal tibiae from RA patients as compared with osteoarthritis (OA) patients as controls. Bone tissue material strength was disrupted in the RA group compared with the control. Collagen/apatite micro-arrangement and vBMD were significantly lower in the RA group, and the rate of decrease in apatite c-axis orientation (−45%) was larger than that in vBMD (−22%). Multiple regression analysis showed that the degree of apatite c-axis orientation (β = 0.52, p = 1.9 × 10−2) significantly contributed to RA-induced bone material impairment as well as vBMD (β = 0.46, p = 3.8 × 10−2). To the best of our knowledge, this is the first report to demonstrate that RA reduces bone material strength by deteriorating the micro-arrangement of collagen/apatite bone matrix, leading to decreased fracture resistance. Our findings represent the significance of bone quality-based analysis for precise evaluation and subsequent therapy of the integrity and soundness of the bone in patients with RA.
Publisher	Elsevier
Source Title	Bone
Volume (Issue)	155
Page	116261
Date of Issued	2022-02-01
Language	English
Handle URL	https://hdl.handle.net/11094/89758
PISSN	87563282
NCID	AA10681613
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1016/j.bone.2021.116261
Access Rights	open access
CopyRight	This article is licensed under a Creative Commons Attribution 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCMI Type	Text
DCTERMS.bibliographicCitation	Bone. 2022, 155, p. 116261
DC.title	Bone fragility via degradation of bone quality featured by collagen/apatite micro-arrangement in human rheumatic arthritis
DC.creator	Ozasa, Ryosuke
	Matsugaki, Aira
	Ishimoto, Takuya
	Kamura, Satoshi
	Yoshida, Hiroto
	Magi, Mayu
	Matsumoto, Yoshihiro
	Sakuraba, Koji
	Fujimura, Kenjiro
	Miyahara, Hisaaki
	Nakano, Takayoshi
DC.publisher	Elsevier
DC.language' scheme='DCTERMS.RFC1766	English
DC.type' scheme='DCTERMS.DCMIType	Text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2022-02-01
DC.identifier	https://doi.org/10.1016/j.bone.2021.116261
DC.subject	Bone quality
	Collagen/apatite orientation
	Fracture risk assessment
	Human knee joint
	Interleukin-6
	Osteocyte
	Rheumatoid arthritis
DC.description	Ozasa R., Matsugaki A., Ishimoto T., et al. Bone fragility via degradation of bone quality featured by collagen/apatite micro-arrangement in human rheumatic arthritis. Bone, 155, 116261. https://doi.org/10.1016/j.bone.2021.116261.
DCTERMS.abstract	Although increased bone fragility is a well-recognized consequence in patients with rheumatoid arthritis (RA), the essential cause of degenerate bone strength remains unknown. This study aimed to determine factors contributing to bone dysfunction in RA by focusing on the bone matrix micro-arrangement, based on the preferential orientation of collagen and the related apatite c-axis as a bone quality index. The classical understanding of RA is limited to its severe pathological conditions associated with inflammation-induced bone loss. This study examined periarticular proximal tibiae from RA patients as compared with osteoarthritis (OA) patients as controls. Bone tissue material strength was disrupted in the RA group compared with the control. Collagen/apatite micro-arrangement and vBMD were significantly lower in the RA group, and the rate of decrease in apatite c-axis orientation (−45%) was larger than that in vBMD (−22%). Multiple regression analysis showed that the degree of apatite c-axis orientation (β = 0.52, p = 1.9 × 10−2) significantly contributed to RA-induced bone material impairment as well as vBMD (β = 0.46, p = 3.8 × 10−2). To the best of our knowledge, this is the first report to demonstrate that RA reduces bone material strength by deteriorating the micro-arrangement of collagen/apatite bone matrix, leading to decreased fracture resistance. Our findings represent the significance of bone quality-based analysis for precise evaluation and subsequent therapy of the integrity and soundness of the bone in patients with RA.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	89758
citation_title	Bone fragility via degradation of bone quality featured by collagen/apatite micro-arrangement in human rheumatic arthritis
citation_author	Ozasa, Ryosuke
	Matsugaki, Aira
	Ishimoto, Takuya
	Kamura, Satoshi
	Yoshida, Hiroto
	Magi, Mayu
	Matsumoto, Yoshihiro
	Sakuraba, Koji
	Fujimura, Kenjiro
	Miyahara, Hisaaki
	Nakano, Takayoshi
citation_publisher	Elsevier
citation_language	English
citation_date	2022-02-01
citation_journal_title	Bone
citation_volume	155
citation_firstpage	116261
citation_doi	https://doi.org/10.1016/j.bone.2021.116261
citation_public_url	https://hdl.handle.net/11094/89758

Bone fragility via degradation of bone quality featured by collagen/apatite micro-arrangement in human rheumatic arthritis

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