Re-Evaluation of Initial Bone Mineralization from an Engineering Perspective

Hara, Emilio Satoshi; Okada, Masahiro; Nagaoka, Noriyuki; Nakano, Takayoshi; Matsumoto, Takuya

doi:https://doi.org/10.1089/ten.teb.2020.0352

Re-Evaluation of Initial Bone Mineralization from an Engineering Perspective

Hara, Emilio Satoshi; Okada, Masahiro; Nagaoka, Noriyuki et al.

Tissue Engineering - Part B: Reviews, 2022, 28(1)

Number of Access:652（2025-08-21 04:37 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/89759

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Title	Re-Evaluation of Initial Bone Mineralization from an Engineering Perspective
Creator	NRID 1000040779443 1000040779443 CreatorName Hara, Emilio Satoshi
	NRID 1000070416220 1000070416220 CreatorName Okada, Masahiro
	NRID 1000070304326 1000070304326 CreatorName Nagaoka, Noriyuki
	NRID 1000030243182 1000030243182 ORCID 0000-0001-8052-1698 0000-0001-8052-1698 researchmap permalink read0013987 read0013987 Scopus Author ID 7403896013 7403896013 CreatorName Nakano, Takayoshi
	NRID 1000040324793 1000040324793 CreatorName Matsumoto, Takuya
Description	Hara E.S., Okada M., Nagaoka N., et al. Re-Evaluation of Initial Bone Mineralization from an Engineering Perspective. Tissue Engineering - Part B: Reviews, 28, 1, 246. https://doi.org/10.1089/ten.teb.2020.0352.
Abstract	Bone regeneration was one of the earliest fields to develop in the context of tissue regeneration, and currently, repair of small-sized bone defects has reached a high success rate. Future researches are expected to incorporate more advanced techniques toward achieving rapid bone repair and modulation of the regenerated bone quality. For these purposes, it is important to have a more integrative understanding of the mechanisms of bone formation and maturation from multiple perspectives and to incorporate these new concepts into the development and designing of novel materials and techniques for bone regeneration. This review focuses on the analysis of the earliest stages of bone tissue development from the biology, material science, and engineering perspectives for a more integrative understanding of bone formation and maturation, and for the development of novel biology-based engineering approaches for tissue synthesis in vitro. More specifically, the authors describe the systematic methodology that allowed the understanding of the different nucleation sites in intramembranous and endochondral ossification, the space-making process for mineral formation and growth, as well as the process of apatite crystal cluster growth in vivo in the presence of suppressing biomolecules. A detailed understanding of the developmental process of bone tissue leads to the acquisition of useful information for the bone tissue fabrication. This review summarizes the study of the calcification process of the calvaria and epiphyses from an engineering perspective and provides useful information for the realization of bone tissue biofabrication. Here, we describe the new mechanism of space formation for mineralization such as rupture of chondrocytes and disruption of cell-cell adhesion. We also describe the roles of nucleation site such as cell membrane nanofragments and matrix vesicles.
Publisher	Mary Ann Liebert
Source Title	Tissue Engineering - Part B: Reviews
Volume (Issue)	28(1)
Date of Issued	2022-02-15
Language	English
Handle URL	https://hdl.handle.net/11094/89759
PISSN	19373368
eISSN	19373376
NCID	AA12318308
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1089/ten.teb.2020.0352
Access Rights	open access
CopyRight	This article is licensed under a Creative Commons Attribution 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCMI Type	Text
DCTERMS.bibliographicCitation	Tissue Engineering - Part B: Reviews. 2022, 28(1)
DC.title	Re-Evaluation of Initial Bone Mineralization from an Engineering Perspective
DC.creator	Hara, Emilio Satoshi
	Okada, Masahiro
	Nagaoka, Noriyuki
	Nakano, Takayoshi
	Matsumoto, Takuya
DC.publisher	Mary Ann Liebert
DC.language' scheme='DCTERMS.RFC1766	English
DC.type' scheme='DCTERMS.DCMIType	Text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2022-02-15
DC.identifier	https://doi.org/10.1089/ten.teb.2020.0352
DC.description	Hara E.S., Okada M., Nagaoka N., et al. Re-Evaluation of Initial Bone Mineralization from an Engineering Perspective. Tissue Engineering - Part B: Reviews, 28, 1, 246. https://doi.org/10.1089/ten.teb.2020.0352.
DCTERMS.abstract	Bone regeneration was one of the earliest fields to develop in the context of tissue regeneration, and currently, repair of small-sized bone defects has reached a high success rate. Future researches are expected to incorporate more advanced techniques toward achieving rapid bone repair and modulation of the regenerated bone quality. For these purposes, it is important to have a more integrative understanding of the mechanisms of bone formation and maturation from multiple perspectives and to incorporate these new concepts into the development and designing of novel materials and techniques for bone regeneration. This review focuses on the analysis of the earliest stages of bone tissue development from the biology, material science, and engineering perspectives for a more integrative understanding of bone formation and maturation, and for the development of novel biology-based engineering approaches for tissue synthesis in vitro. More specifically, the authors describe the systematic methodology that allowed the understanding of the different nucleation sites in intramembranous and endochondral ossification, the space-making process for mineral formation and growth, as well as the process of apatite crystal cluster growth in vivo in the presence of suppressing biomolecules. A detailed understanding of the developmental process of bone tissue leads to the acquisition of useful information for the bone tissue fabrication. This review summarizes the study of the calcification process of the calvaria and epiphyses from an engineering perspective and provides useful information for the realization of bone tissue biofabrication. Here, we describe the new mechanism of space formation for mineralization such as rupture of chondrocytes and disruption of cell-cell adhesion. We also describe the roles of nucleation site such as cell membrane nanofragments and matrix vesicles.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	89759
citation_title	Re-Evaluation of Initial Bone Mineralization from an Engineering Perspective
citation_author	Hara, Emilio Satoshi
	Okada, Masahiro
	Nagaoka, Noriyuki
	Nakano, Takayoshi
	Matsumoto, Takuya
citation_publisher	Mary Ann Liebert
citation_language	English
citation_date	2022-02-15
citation_journal_title	Tissue Engineering - Part B: Reviews
citation_volume	28
citation_issue	1
citation_doi	https://doi.org/10.1089/ten.teb.2020.0352
citation_public_url	https://hdl.handle.net/11094/89759

Re-Evaluation of Initial Bone Mineralization from an Engineering Perspective

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