Novel nano-hydroxyapatite coating of additively manufactured three-dimensional porous implants improves bone ingrowth and initial fixation

Watanabe, Ryota; Takahashi, Hiroyuki; Matsugaki, Aira; Uemukai, Toru; Kogai, Yasumichi; Imagama, Takashi; Yukata, Kiminori; Nakano, Takayoshi; Sakai, Takashi

doi:https://doi.org/10.1002/jbm.b.35165

Novel nano-hydroxyapatite coating of additively manufactured three-dimensional porous implants improves bone ingrowth and initial fixation

Watanabe, Ryota; Takahashi, Hiroyuki; Matsugaki, Aira et al.

Journal of Biomedical Materials Research - Part B Applied Biomaterials, 2022, 111(2), 453-462

Number of Access:796（2025-07-27 19:25 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/89761

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Title	Novel nano-hydroxyapatite coating of additively manufactured three-dimensional porous implants improves bone ingrowth and initial fixation
Creator	CreatorName Watanabe, Ryota
	CreatorName Takahashi, Hiroyuki
	NRID 1000010592529 1000010592529 ORCID 0000-0002-8427-7124 0000-0002-8427-7124 researchmap permalink aira aira Scopus Author ID 24172720900 24172720900 CreatorName Matsugaki, Aira
	CreatorName Uemukai, Toru
	CreatorName Kogai, Yasumichi
	CreatorName Imagama, Takashi
	CreatorName Yukata, Kiminori
	NRID 1000030243182 1000030243182 ORCID 0000-0001-8052-1698 0000-0001-8052-1698 researchmap permalink read0013987 read0013987 Scopus Author ID 7403896013 7403896013 CreatorName Nakano, Takayoshi
	CreatorName Sakai, Takashi
Description	Watanabe R., Takahashi H., Matsugaki A., et al. Novel nano-hydroxyapatite coating of additively manufactured three-dimensional porous implants improves bone ingrowth and initial fixation. Journal of Biomedical Materials Research - Part B Applied Biomaterials. https://doi.org/10.1002/jbm.b.35165.
Abstract	Electron beam melting (EBM) has been used to fabricate three-dimensional (3D) porous Ti-6Al-4V surfaces for acetabular cups in total hip arthroplasty. However, there are radiographic concerns regarding poor implant fixation and bone ingrowth around electron beam melted (EBMed) 3D porous cups. We hypothesize that nano-hydroxyapatite (nHA) coating can promote bone ingrowth and thus decrease the occurrence of radiolucent lines around EBMed 3D porous cups. This study aimed to investigate the effect of a novel nHA coating on the biological performance of EBMed 3D porous implants in a beagle transcortical model. Low-porosity (control) and high-porosity 3D porous Ti-6Al-4V implants were manufactured using EBM. Half of the high-porosity implants were coated with nHA without clogging the 3D pores. Implants were inserted into the femoral diaphysis of the beagles. The beagles were euthanized at 4, 8, and 12 weeks postoperatively, and push-out testing was performed. Bone ingrowth was evaluated by histological analysis. Although the increase in porosity alone had no effect on biological behavior, the addition of nHA to high-porosity 3D implants significantly improved early bone fixation and bone ingrowth into the deep region of porous structures compared to low-porosity implants. This is the first report of a novel nHA coating that improved bone ingrowth into the deeper regions of 3D porous implants, which can prevent the occurrence of radiolucent lines around EBMed 3D porous cups.
Publisher	John Wiley and Sons
Source Title	Journal of Biomedical Materials Research - Part B Applied Biomaterials
Volume (Issue)	111(2)
Page	453-462
Date of Issued	2022-09-28
Language	English
Handle URL	https://hdl.handle.net/11094/89761
PISSN	15524973
eISSN	15524981
NCID	AA11881538
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1002/jbm.b.35165
Access Rights	open access
CopyRight	This article is licensed under a Creative Commons Attribution 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCMI Type	Text
DCTERMS.bibliographicCitation	Journal of Biomedical Materials Research - Part B Applied Biomaterials. 2022, 111(2), p. 453-462
DC.title	Novel nano-hydroxyapatite coating of additively manufactured three-dimensional porous implants improves bone ingrowth and initial fixation
DC.creator	Watanabe, Ryota
	Takahashi, Hiroyuki
	Matsugaki, Aira
	Uemukai, Toru
	Kogai, Yasumichi
	Imagama, Takashi
	Yukata, Kiminori
	Nakano, Takayoshi
	Sakai, Takashi
DC.publisher	John Wiley and Sons
DC.language' scheme='DCTERMS.RFC1766	English
DC.type' scheme='DCTERMS.DCMIType	Text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2022-09-28
DC.identifier	https://doi.org/10.1002/jbm.b.35165
DC.description	Watanabe R., Takahashi H., Matsugaki A., et al. Novel nano-hydroxyapatite coating of additively manufactured three-dimensional porous implants improves bone ingrowth and initial fixation. Journal of Biomedical Materials Research - Part B Applied Biomaterials. https://doi.org/10.1002/jbm.b.35165.
DCTERMS.abstract	Electron beam melting (EBM) has been used to fabricate three-dimensional (3D) porous Ti-6Al-4V surfaces for acetabular cups in total hip arthroplasty. However, there are radiographic concerns regarding poor implant fixation and bone ingrowth around electron beam melted (EBMed) 3D porous cups. We hypothesize that nano-hydroxyapatite (nHA) coating can promote bone ingrowth and thus decrease the occurrence of radiolucent lines around EBMed 3D porous cups. This study aimed to investigate the effect of a novel nHA coating on the biological performance of EBMed 3D porous implants in a beagle transcortical model. Low-porosity (control) and high-porosity 3D porous Ti-6Al-4V implants were manufactured using EBM. Half of the high-porosity implants were coated with nHA without clogging the 3D pores. Implants were inserted into the femoral diaphysis of the beagles. The beagles were euthanized at 4, 8, and 12 weeks postoperatively, and push-out testing was performed. Bone ingrowth was evaluated by histological analysis. Although the increase in porosity alone had no effect on biological behavior, the addition of nHA to high-porosity 3D implants significantly improved early bone fixation and bone ingrowth into the deep region of porous structures compared to low-porosity implants. This is the first report of a novel nHA coating that improved bone ingrowth into the deeper regions of 3D porous implants, which can prevent the occurrence of radiolucent lines around EBMed 3D porous cups.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	89761
citation_title	Novel nano-hydroxyapatite coating of additively manufactured three-dimensional porous implants improves bone ingrowth and initial fixation
citation_author	Watanabe, Ryota
	Takahashi, Hiroyuki
	Matsugaki, Aira
	Uemukai, Toru
	Kogai, Yasumichi
	Imagama, Takashi
	Yukata, Kiminori
	Nakano, Takayoshi
	Sakai, Takashi
citation_publisher	John Wiley and Sons
citation_language	English
citation_date	2022-09-28
citation_journal_title	Journal of Biomedical Materials Research - Part B Applied Biomaterials
citation_volume	111
citation_issue	2
citation_firstpage	453
citation_lastpage	462
citation_doi	https://doi.org/10.1002/jbm.b.35165
citation_public_url	https://hdl.handle.net/11094/89761

Novel nano-hydroxyapatite coating of additively manufactured three-dimensional porous implants improves bone ingrowth and initial fixation

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