Development of orthophosphosilicate glass/poly(lactic acid) composite anisotropic scaffolds for simultaneous reconstruction of bone quality and quantity

Lee, Sungho; Nagata, Fukue; Kato, Katsuya et al.

Journal of Biomedical Materials Research - Part A, 2020, 109(5), 788-803

Number of Access:390（2025-08-21 04:38 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/89786

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Title
Development of orthophosphosilicate glass/poly(lactic acid) composite anisotropic scaffolds for simultaneous reconstruction of bone quality and quantity
Creator
NRID
1000020850001 1000020850001
CreatorName
Lee, Sungho
NRID
1000000357633 1000000357633
CreatorName
Nagata, Fukue
NRID
1000070356781 1000070356781
CreatorName
Kato, Katsuya
NRID
1000030233729 1000030233729
CreatorName
Kasuga, Toshihiro
NRID
1000030243182 1000030243182
ORCID
0000-0001-8052-1698 0000-0001-8052-1698
researchmap permalink
read0013987 read0013987
Scopus Author ID
7403896013 7403896013
CreatorName
Nakano, Takayoshi
Description
Lee S., Nagata F., Kato K., et al. Development of orthophosphosilicate glass/poly(lactic acid) composite anisotropic scaffolds for simultaneous reconstruction of bone quality and quantity. Journal of Biomedical Materials Research - Part A, 109, 5, 788. https://doi.org/10.1002/jbm.a.37067.
Abstract
Reconstruction of organ-specific architecture is necessary to recover the original organ function. The anisotropic structure of bone tissue is strongly related to the collagen fibril alignment and bone apatite crystal direction. Bone regeneration indicates following two main process; first, restoration of bone mineral density (BMD; bone quantity), and second, restoring bone apatite c-axis orientation (bone quality). In addition to BMD, bone quality is the most important factor among bone mechanical properties. Recovery of the original bone function requires development of novel scaffolds with simultaneous reconstruction of bone quality and quantity. Herein, novel orthophosphosilicate glass (PSG)/poly(lactic acid) composite anisotropic scaffolds were developed to control cell alignment and enhance bone formation, which are important for the simultaneous reconstruction of bone quality and quantity. The strategy to control cell alignment and bone formation involved designing anisotropic scaffolds in combination with the release of therapeutic ions by PSGs. The morphology of fibrous scaffolds containing PSGs was quantitatively designed using electrospinning. This successfully modulated cell alignment and subsequent bone apatite c-axis orientation along the fiber-oriented direction. The released silicate and Mg2+ ions from PSGs in scaffolds improved cell adhesion, proliferation, and calcification. To best of our knowledge, this is the first report demonstrating that the anisotropic scaffolds containing bioactive glasses regenerate bone tissues with simultaneous reconstruction of bone quality and quantity via stimulating osteoblasts by inorganic ions and designing morphology of scaffolds.
Publisher
John Wiley and Sons
Source Title
Journal of Biomedical Materials Research - Part A
Volume (Issue)
109(5)
Page
788-803
Date of Issued
2020-07-27
Language
English
Handle URL
https://hdl.handle.net/11094/89786
PISSN
15493296
eISSN
15524965
NCID
AA11881516
Relation.isIdenticalTo
DOI (Publisher Version)
https://doi.org/10.1002/jbm.a.37067
Access Rights
open access
CopyRight
This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
oaire:version
Version of Record
Category
学術雑誌論文 Journal Article