Impaired alignment of bone matrix microstructure associated with disorganized osteoblast arrangement in malignant melanoma metastasis

Matsugaki, Aira; Kimura, Yumi; Watanabe, Ryota; Nakamura, Fumihito; Takehana, Ryo; Nakano, Takayoshi

doi:https://doi.org/10.3390/biom11020131

Impaired alignment of bone matrix microstructure associated with disorganized osteoblast arrangement in malignant melanoma metastasis

Matsugaki, Aira; Kimura, Yumi; Watanabe, Ryota et al.

Biomolecules, 2021, 11(2), 131

Number of Access:535（2025-07-27 21:19 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/89790

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Title	Impaired alignment of bone matrix microstructure associated with disorganized osteoblast arrangement in malignant melanoma metastasis
Creator	NRID 1000010592529 1000010592529 ORCID 0000-0002-8427-7124 0000-0002-8427-7124 researchmap permalink aira aira Scopus Author ID 24172720900 24172720900 CreatorName Matsugaki, Aira
	CreatorName Kimura, Yumi
	CreatorName Watanabe, Ryota
	CreatorName Nakamura, Fumihito
	CreatorName Takehana, Ryo
	NRID 1000030243182 1000030243182 ORCID 0000-0001-8052-1698 0000-0001-8052-1698 researchmap permalink read0013987 read0013987 Scopus Author ID 7403896013 7403896013 CreatorName Nakano, Takayoshi
Subject	Bone tissue microstructure
	Ex vivo metastasis model
	Malignant melanoma
	Osteoblast
Description	Matsugaki A., Kimura Y., Watanabe R., et al. Impaired alignment of bone matrix microstructure associated with disorganized osteoblast arrangement in malignant melanoma metastasis. Biomolecules, 11, 2, 1. https://doi.org/10.3390/biom11020131.
Abstract	Malignant melanoma favors spreading to bone, resulting in a weakened bone with a high fracture risk. Here, we revealed the disorganized alignment of apatite crystals in the bone matrix associated with the homing of cancer cells by developing an artificially controlled ex vivo melanoma bone metastasis model. The ex vivo metastasis model reflects the progressive melanoma cell activation in vivo, resulting in decreased bone mineral density and expression of MMP1-positive cells. Moreover, less organized intercellular connections were observed in the neighboring osteoblasts in metastasized bone, indicating the abnormal and randomized organization of bone matrix secreted by disconnected osteoblasts. Our study revealed that the deteriorated microstructure associated with disorganized osteoblast arrangement was a determinant of malignant melanoma-related bone dysfunction.
Publisher	MDPI
Source Title	Biomolecules
Volume (Issue)	11(2)
Page	131
Date of Issued	2021-01-20
Language	English
Handle URL	https://hdl.handle.net/11094/89790
eISSN	2218273X
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.3390/biom11020131
Access Rights	open access
CopyRight	This article is licensed under a Creative Commons Attribution 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCMI Type	Text
DCTERMS.bibliographicCitation	Biomolecules. 2021, 11(2), p. 131
DC.title	Impaired alignment of bone matrix microstructure associated with disorganized osteoblast arrangement in malignant melanoma metastasis
DC.creator	Matsugaki, Aira
	Kimura, Yumi
	Watanabe, Ryota
	Nakamura, Fumihito
	Takehana, Ryo
	Nakano, Takayoshi
DC.publisher	MDPI
DC.language' scheme='DCTERMS.RFC1766	English
DC.type' scheme='DCTERMS.DCMIType	Text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2021-01-20
DC.identifier	https://doi.org/10.3390/biom11020131
DC.subject	Bone tissue microstructure
	Ex vivo metastasis model
	Malignant melanoma
	Osteoblast
DC.description	Matsugaki A., Kimura Y., Watanabe R., et al. Impaired alignment of bone matrix microstructure associated with disorganized osteoblast arrangement in malignant melanoma metastasis. Biomolecules, 11, 2, 1. https://doi.org/10.3390/biom11020131.
DCTERMS.abstract	Malignant melanoma favors spreading to bone, resulting in a weakened bone with a high fracture risk. Here, we revealed the disorganized alignment of apatite crystals in the bone matrix associated with the homing of cancer cells by developing an artificially controlled ex vivo melanoma bone metastasis model. The ex vivo metastasis model reflects the progressive melanoma cell activation in vivo, resulting in decreased bone mineral density and expression of MMP1-positive cells. Moreover, less organized intercellular connections were observed in the neighboring osteoblasts in metastasized bone, indicating the abnormal and randomized organization of bone matrix secreted by disconnected osteoblasts. Our study revealed that the deteriorated microstructure associated with disorganized osteoblast arrangement was a determinant of malignant melanoma-related bone dysfunction.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	89790
citation_title	Impaired alignment of bone matrix microstructure associated with disorganized osteoblast arrangement in malignant melanoma metastasis
citation_author	Matsugaki, Aira
	Kimura, Yumi
	Watanabe, Ryota
	Nakamura, Fumihito
	Takehana, Ryo
	Nakano, Takayoshi
citation_publisher	MDPI
citation_language	English
citation_date	2021-01-20
citation_journal_title	Biomolecules
citation_volume	11
citation_issue	2
citation_firstpage	131
citation_doi	https://doi.org/10.3390/biom11020131
citation_public_url	https://hdl.handle.net/11094/89790

Impaired alignment of bone matrix microstructure associated with disorganized osteoblast arrangement in malignant melanoma metastasis

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