A novel role of interleukin-6 as a regulatory factor of inflammation-associated deterioration in osteoblast arrangement

Matsugaki, Aira; Matsumoto, Shun; Nakano, Takayoshi

International Journal of Molecular Sciences, 2020, 21(18)

Number of Access:387（2025-07-27 21:18 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/89798

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Title
A novel role of interleukin-6 as a regulatory factor of inflammation-associated deterioration in osteoblast arrangement
Creator
NRID
1000010592529 1000010592529
ORCID
0000-0002-8427-7124 0000-0002-8427-7124
researchmap permalink
aira aira
Scopus Author ID
24172720900 24172720900
CreatorName
Matsugaki, Aira
CreatorName
Matsumoto, Shun
NRID
1000030243182 1000030243182
ORCID
0000-0001-8052-1698 0000-0001-8052-1698
researchmap permalink
read0013987 read0013987
Scopus Author ID
7403896013 7403896013
CreatorName
Nakano, Takayoshi
Subject
Bone microstructure
Cell arrangement
Interleukin-6
Macrophage
Osteoblast
Description
Matsugaki A., Matsumoto S., Nakano T.. A novel role of interleukin-6 as a regulatory factor of inflammation-associated deterioration in osteoblast arrangement. International Journal of Molecular Sciences, 21, 18, 1. https://doi.org/10.3390/ijms21186659.
Abstract
Inflammatory disorders are associated with bone destruction; that is, deterioration in bone cell activities are under the control of the innate immune system. Macrophages play a central role in innate immunity by switching their polarized phenotype. A disturbed immune system causes aberrance in the ordered bone matrix microarrangement, which is a dominant determinant of bone tissue functionalization. However, the precise relationship between the immune system and bone tissue organization is unknown. In this study, the controlled in vitro co-culture assay results showed that M1-polarized macrophages disrupted the osteoblast alignment, which directly modulate the oriented bone matrix organization, by secreting pro-inflammatory cytokines. Notably, interleukin6 was found to be a key regulator of unidirectional osteoblast alignment. Our results demonstrated that inflammatory diseases triggered bone dysfunction by regulating the molecular interaction between the immune system and bone tissue organization. These findings may contribute to the development of therapeutic targets for inflammatory disorders, including rheumatoid arthritis.
Publisher
MDPI
Source Title
International Journal of Molecular Sciences
Volume (Issue)
21(18)
Date of Issued
2020-09-11
Language
English
Handle URL
https://hdl.handle.net/11094/89798
PISSN
16616596
eISSN
14220067
Relation.isIdenticalTo
DOI (Publisher Version)
https://doi.org/10.3390/ijms21186659
Access Rights
open access
CopyRight
This article is licensed under a Creative Commons Attribution 4.0 International License.
oaire:version
Version of Record
Category
学術雑誌論文 Journal Article