Assessment of the functional efficacy of root canal treatment with high-frequency waves in rats

Matsui, Saori; Yoneda, Naomichi; Maezono, Hazuki et al.

PLoS ONE, 2020, 15(9), e0239660

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Identifier to cite or link to this item: https://hdl.handle.net/11094/89799

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Title
Assessment of the functional efficacy of root canal treatment with high-frequency waves in rats
Creator
NRID
1000090823568 1000090823568
CreatorName
Matsui, Saori
NRID
1000080781640 1000080781640
CreatorName
Yoneda, Naomichi
NRID
1000000613390 1000000613390
researchmap permalink
h-maezono h-maezono
Scopus Author ID
52463972400 52463972400
CreatorName
Maezono, Hazuki
NRID
1000040734306 1000040734306
CreatorName
Kuremoto, Katsutaka
NRID
1000050508835 1000050508835
ORCID
0000-0003-0081-0591 0000-0003-0081-0591
researchmap permalink
i_taku i_taku
Scopus Author ID
35310484700 35310484700
CreatorName
Ishimoto, Takuya
NRID
1000030243182 1000030243182
ORCID
0000-0001-8052-1698 0000-0001-8052-1698
researchmap permalink
read0013987 read0013987
Scopus Author ID
7403896013 7403896013
CreatorName
Nakano, Takayoshi
NRID
1000060284303 1000060284303
CreatorName
Yumoto, Hiromichi
NRID
1000050116000 1000050116000
CreatorName
Ebisu, Shigeyuki
NRID
1000050218286 1000050218286
CreatorName
Noiri, Yuichiro
NRID
1000040271027 1000040271027
researchmap permalink
read0185244 read0185244
Scopus Author ID
26021225700 26021225700
CreatorName
Hayashi, Mikako
Description
Assessment of the functional efficacy of root canal treatment with high-frequency waves in rats. Saori Matsui, et al. PLOS ONE. 2020.9(29) doi.org/10.1371/journal.pone.0239660
Abstract
The purpose of this study was to develop a high-frequency wave therapy model in rats and to investigate the influence of high-frequency waves on root canal treatment, which may provide a novel strategy for treating apical periodontitis. Root canal treatments with and without high-frequency wave irradiation were performed on the mandibular first molars of 10-week-old male Wistar rats. The mesial roots were evaluated radiologically, bacteriologically, and immunohistochemically. At 3 weeks after root canal treatment, lesion volume had decreased significantly more in the irradiated group than in the non-irradiated group, indicating successful development of the high-frequency therapy model. The use of high-frequency waves provided no additional bactericidal effect after root canal treatment. However, high-frequency wave irradiation was found to promote healing of periapical lesions on the host side through increased expression of fibroblast growth factor 2 and transforming growth factor-β1 and could therefore be useful as an adjuvant nonsurgical treatment for apical periodontitis.
Publisher
Public Library of Science
Source Title
PLoS ONE
Volume (Issue)
15(9)
Page
e0239660
Date of Issued
2020-09-29
Language
English
Handle URL
https://hdl.handle.net/11094/89799
eISSN
19326203
Relation.isIdenticalTo
DOI (Publisher Version)
https://doi.org/10.1371/journal.pone.0239660
Access Rights
open access
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This article is licensed under a Creative Commons Attribution 4.0 International License.
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Category
学術雑誌論文 Journal Article