Impaired bone quality characterized by apatite orientation under stress shielding following fixing of a fracture of the radius with a 3D printed Ti-6Al-4V custom-made bone plate in dogs

Mie, Keiichiro; Ishimoto, Takuya; Okamoto, Mari; Iimori, Yasumasa; Ashida, Kazuna; Yoshizaki, Karin; Nishida, Hidetaka; Nakano, Takayoshi; Akiyoshi, Hideo

doi:https://doi.org/10.1371/journal.pone.0237678

Impaired bone quality characterized by apatite orientation under stress shielding following fixing of a fracture of the radius with a 3D printed Ti-6Al-4V custom-made bone plate in dogs

Mie, Keiichiro; Ishimoto, Takuya; Okamoto, Mari et al.

PLoS ONE, 2020, 15(9), e0237678

Number of Access:518（2025-07-18 09:48 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/89800

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Title	Impaired bone quality characterized by apatite orientation under stress shielding following fixing of a fracture of the radius with a 3D printed Ti-6Al-4V custom-made bone plate in dogs
Creator	CreatorName Mie, Keiichiro
	NRID 1000050508835 1000050508835 ORCID 0000-0003-0081-0591 0000-0003-0081-0591 researchmap permalink i_taku i_taku Scopus Author ID 35310484700 35310484700 CreatorName Ishimoto, Takuya
	CreatorName Okamoto, Mari
	CreatorName Iimori, Yasumasa
	CreatorName Ashida, Kazuna
	CreatorName Yoshizaki, Karin
	NRID 1000000622804 1000000622804 CreatorName Nishida, Hidetaka
	NRID 1000030243182 1000030243182 ORCID 0000-0001-8052-1698 0000-0001-8052-1698 researchmap permalink read0013987 read0013987 Scopus Author ID 7403896013 7403896013 CreatorName Nakano, Takayoshi
	NRID 1000050420740 1000050420740 CreatorName Akiyoshi, Hideo
Description	Impaired bone quality characterized by apatite orientation under stress shielding following fixing of a fracture of the radius with a 3D printed Ti-6Al-4V custom-made bone plate in dogs. Keiichiro Mie et al. PLOS ONE. 2020. 9(2) doi.org/10.1371/journal.pone.0237678
Abstract	Custom-made implants have recently gained attention in veterinary medicine because of their ability to properly fit animal bones having a wide variety of shapes and sizes. The effect of custom-made implants on bone soundness and the regeneration process is not yet clear. We fabricated a 3D printed Ti-6Al-4V custom-made bone plate that fits the shape of the dog radius, and placed it into the radius where an osteotomy had been made. The preferential orientation of the apatite c-axis contributes to the mechanical integrity of the bone and is a reliable measure of bone quality. We determined this parameter as well as the bone shape and bone mineral density (BMD). The bone portion which lies parallel to the bone plate exhibited bone resorption, decreased BMD, and significant degradation of apatite orientation, relative to the portion outside the plate, at 7 months after the operation. This demonstrates the presence of stress shielding in which applied stress is not transmitted to bone due to the insertion of a stiff bone plate. This reduced stress condition clearly influences the bone regeneration process. The apatite orientation in the regenerated site remained different even after 7 months of regeneration, indicating insufficient mechanical function in the regenerated portion. This is the first study in which the apatite orientation and BMD of the radius were evaluated under conditions of stress shielding in dogs. Our results suggest that assessment of bone repair by radiography can indicate the degree of restoration of BMD, but not the apatite orientation.
Publisher	Public Library of Science
Source Title	PLoS ONE
Volume (Issue)	15(9)
Page	e0237678
Date of Issued	2020-09-02
Language	English
Handle URL	https://hdl.handle.net/11094/89800
eISSN	19326203
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1371/journal.pone.0237678
Access Rights	open access
CopyRight	This article is licensed under a Creative Commons Attribution 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCMI Type	Text
DCTERMS.bibliographicCitation	PLoS ONE. 2020, 15(9), p. e0237678
DC.title	Impaired bone quality characterized by apatite orientation under stress shielding following fixing of a fracture of the radius with a 3D printed Ti-6Al-4V custom-made bone plate in dogs
DC.creator	Mie, Keiichiro
	Ishimoto, Takuya
	Okamoto, Mari
	Iimori, Yasumasa
	Ashida, Kazuna
	Yoshizaki, Karin
	Nishida, Hidetaka
	Nakano, Takayoshi
	Akiyoshi, Hideo
DC.publisher	Public Library of Science
DC.language' scheme='DCTERMS.RFC1766	English
DC.type' scheme='DCTERMS.DCMIType	Text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2020-09-02
DC.identifier	https://doi.org/10.1371/journal.pone.0237678
DC.description	Impaired bone quality characterized by apatite orientation under stress shielding following fixing of a fracture of the radius with a 3D printed Ti-6Al-4V custom-made bone plate in dogs. Keiichiro Mie et al. PLOS ONE. 2020. 9(2) doi.org/10.1371/journal.pone.0237678
DCTERMS.abstract	Custom-made implants have recently gained attention in veterinary medicine because of their ability to properly fit animal bones having a wide variety of shapes and sizes. The effect of custom-made implants on bone soundness and the regeneration process is not yet clear. We fabricated a 3D printed Ti-6Al-4V custom-made bone plate that fits the shape of the dog radius, and placed it into the radius where an osteotomy had been made. The preferential orientation of the apatite c-axis contributes to the mechanical integrity of the bone and is a reliable measure of bone quality. We determined this parameter as well as the bone shape and bone mineral density (BMD). The bone portion which lies parallel to the bone plate exhibited bone resorption, decreased BMD, and significant degradation of apatite orientation, relative to the portion outside the plate, at 7 months after the operation. This demonstrates the presence of stress shielding in which applied stress is not transmitted to bone due to the insertion of a stiff bone plate. This reduced stress condition clearly influences the bone regeneration process. The apatite orientation in the regenerated site remained different even after 7 months of regeneration, indicating insufficient mechanical function in the regenerated portion. This is the first study in which the apatite orientation and BMD of the radius were evaluated under conditions of stress shielding in dogs. Our results suggest that assessment of bone repair by radiography can indicate the degree of restoration of BMD, but not the apatite orientation.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	89800
citation_title	Impaired bone quality characterized by apatite orientation under stress shielding following fixing of a fracture of the radius with a 3D printed Ti-6Al-4V custom-made bone plate in dogs
citation_author	Mie, Keiichiro
	Ishimoto, Takuya
	Okamoto, Mari
	Iimori, Yasumasa
	Ashida, Kazuna
	Yoshizaki, Karin
	Nishida, Hidetaka
	Nakano, Takayoshi
	Akiyoshi, Hideo
citation_publisher	Public Library of Science
citation_language	English
citation_date	2020-09-02
citation_journal_title	PLoS ONE
citation_volume	15
citation_issue	9
citation_firstpage	e0237678
citation_doi	https://doi.org/10.1371/journal.pone.0237678
citation_public_url	https://hdl.handle.net/11094/89800

Impaired bone quality characterized by apatite orientation under stress shielding following fixing of a fracture of the radius with a 3D printed Ti-6Al-4V custom-made bone plate in dogs

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