UVA-activated riboflavin promotes collagen crosslinking to prevent root caries

Uemura, R.; Miura, J.; Ishimoto, T.; Yagi, K.; Matsuda, Y.; Shimizu, M.; Nakano, T.; Hayashi, M.

doi:https://doi.org/10.1038/s41598-018-38137-7

UVA-activated riboflavin promotes collagen crosslinking to prevent root caries

Uemura, R.; Miura, J.; Ishimoto, T. et al.

Scientific Reports, 2019, 9, 1252

Number of Access:1,007（2025-07-18 09:49 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/89811

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Title	UVA-activated riboflavin promotes collagen crosslinking to prevent root caries
Creator	CreatorName Uemura, R.
	CreatorName Miura, J.
	NRID 1000050508835 1000050508835 ORCID 0000-0003-0081-0591 0000-0003-0081-0591 researchmap permalink i_taku i_taku Scopus Author ID 35310484700 35310484700 CreatorName Ishimoto, T.
	CreatorName Yagi, K.
	CreatorName Matsuda, Y.
	CreatorName Shimizu, M.
	NRID 1000030243182 1000030243182 ORCID 0000-0001-8052-1698 0000-0001-8052-1698 researchmap permalink read0013987 read0013987 Scopus Author ID 7403896013 7403896013 CreatorName Nakano, T.
	NRID 1000040271027 1000040271027 researchmap permalink read0185244 read0185244 Scopus Author ID 26021225700 26021225700 CreatorName Hayashi, M.
Description	Uemura R., Miura J., Ishimoto T., et al. UVA-activated riboflavin promotes collagen crosslinking to prevent root caries. Scientific Reports, 9, 1, 1252. https://doi.org/10.1038/s41598-018-38137-7.
Abstract	Root caries is an increasingly problem in aging societies with severe implications for the general health and wellbeing of large numbers of people. Strengthening type-I collagen, a major organic component of human dentin, has proved effective in preventing root caries. This study sought to determine whether exposure to riboflavin followed by UVA irradiation (RF/UVA) could promote additional collagen crosslinking, and thus improve the acid and enzymatic resistance of human dentin under simulated oral environments. If so, it could offer potential for treatment of the intractable problem of root caries. The greatest flexural strengths were found in dentin exposed to a 0.1% riboflavin solution for 1 minute followed by 1,600 mW/cm2 UVA irradiation for 10 minutes. Mineral loss and lesion depth were significantly lower in the RF/UVA group than in the control group. The microstructures of dentinal tubules and collagen networks after RF/UVA treatment retained their original forms after acidic and enzymatic degradation. In conclusion, RF/UVA treatment may be a new method for preventing root caries with promising prospects for clinical application.
Publisher	Nature Publishing Group
Source Title	Scientific Reports
Volume (Issue)	9
Page	1252
Date of Issued	2019-02-04
Language	English
Handle URL	https://hdl.handle.net/11094/89811
eISSN	20452322
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1038/s41598-018-38137-7
Access Rights	open access
CopyRight	This article is licensed under a Creative Commons Attribution 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCMI Type	Text
DCTERMS.bibliographicCitation	Scientific Reports. 2019, 9, p. 1252
DC.title	UVA-activated riboflavin promotes collagen crosslinking to prevent root caries
DC.creator	Uemura, R.
	Miura, J.
	Ishimoto, T.
	Yagi, K.
	Matsuda, Y.
	Shimizu, M.
	Nakano, T.
	Hayashi, M.
DC.publisher	Nature Publishing Group
DC.language' scheme='DCTERMS.RFC1766	English
DC.type' scheme='DCTERMS.DCMIType	Text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2019-02-04
DC.identifier	https://doi.org/10.1038/s41598-018-38137-7
DC.description	Uemura R., Miura J., Ishimoto T., et al. UVA-activated riboflavin promotes collagen crosslinking to prevent root caries. Scientific Reports, 9, 1, 1252. https://doi.org/10.1038/s41598-018-38137-7.
DCTERMS.abstract	Root caries is an increasingly problem in aging societies with severe implications for the general health and wellbeing of large numbers of people. Strengthening type-I collagen, a major organic component of human dentin, has proved effective in preventing root caries. This study sought to determine whether exposure to riboflavin followed by UVA irradiation (RF/UVA) could promote additional collagen crosslinking, and thus improve the acid and enzymatic resistance of human dentin under simulated oral environments. If so, it could offer potential for treatment of the intractable problem of root caries. The greatest flexural strengths were found in dentin exposed to a 0.1% riboflavin solution for 1 minute followed by 1,600 mW/cm2 UVA irradiation for 10 minutes. Mineral loss and lesion depth were significantly lower in the RF/UVA group than in the control group. The microstructures of dentinal tubules and collagen networks after RF/UVA treatment retained their original forms after acidic and enzymatic degradation. In conclusion, RF/UVA treatment may be a new method for preventing root caries with promising prospects for clinical application.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	89811
citation_title	UVA-activated riboflavin promotes collagen crosslinking to prevent root caries
citation_author	Uemura, R.
	Miura, J.
	Ishimoto, T.
	Yagi, K.
	Matsuda, Y.
	Shimizu, M.
	Nakano, T.
	Hayashi, M.
citation_publisher	Nature Publishing Group
citation_language	English
citation_date	2019-02-04
citation_journal_title	Scientific Reports
citation_volume	9
citation_firstpage	1252
citation_doi	https://doi.org/10.1038/s41598-018-38137-7
citation_public_url	https://hdl.handle.net/11094/89811

UVA-activated riboflavin promotes collagen crosslinking to prevent root caries

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