Quantitative ultrasound (QUS) axial transmission method reflects anisotropy in micro-arrangement of apatite crystallites in human long bones: A study with 3-MHz-frequency ultrasound

Ishimoto, Takuya; Suetoshi, Ryoichi; Cretin, Dorian; Hagihara, Koji; Hashimoto, Jun; Kobayashi, Akio; Nakano, Takayoshi

doi:https://doi.org/10.1016/j.bone.2019.05.034

Quantitative ultrasound (QUS) axial transmission method reflects anisotropy in micro-arrangement of apatite crystallites in human long bones: A study with 3-MHz-frequency ultrasound

Ishimoto, Takuya; Suetoshi, Ryoichi; Cretin, Dorian et al.

Bone, 2019, 127, 82-90

Number of Access:663（2025-07-18 09:52 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/89815

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Title	Quantitative ultrasound (QUS) axial transmission method reflects anisotropy in micro-arrangement of apatite crystallites in human long bones: A study with 3-MHz-frequency ultrasound
Creator	NRID 1000050508835 1000050508835 ORCID 0000-0003-0081-0591 0000-0003-0081-0591 researchmap permalink i_taku i_taku Scopus Author ID 35310484700 35310484700 CreatorName Ishimoto, Takuya
	CreatorName Suetoshi, Ryoichi
	CreatorName Cretin, Dorian
	NRID 1000010346182 1000010346182 researchmap permalink read0191194 read0191194 Scopus Author ID 7007016278 7007016278 CreatorName Hagihara, Koji
	NRID 1000040237938 1000040237938 CreatorName Hashimoto, Jun
	CreatorName Kobayashi, Akio
	NRID 1000030243182 1000030243182 ORCID 0000-0001-8052-1698 0000-0001-8052-1698 researchmap permalink read0013987 read0013987 Scopus Author ID 7403896013 7403896013 CreatorName Nakano, Takayoshi
Subject	Anisotropy
	Apatite orientation
	Bone quality
	Leaky surface wave
	Speed of sound (SOS)
Description	Ishimoto T., Suetoshi R., Cretin D., et al. Quantitative ultrasound (QUS) axial transmission method reflects anisotropy in micro-arrangement of apatite crystallites in human long bones: A study with 3-MHz-frequency ultrasound. Bone, 127, 82. https://doi.org/10.1016/j.bone.2019.05.034.
Abstract	Anisotropic arrangement of apatite crystallites, i.e., preferential orientation of the apatite c-axis, is known to be an important bone quality parameter that governs the mechanical properties. However, noninvasive evaluation of apatite orientation has not been achieved to date. The present paper reports the potential of quantitative ultrasound (QUS) for noninvasive evaluation of the degree of apatite orientation in human bone for the first time. A novel QUS instrument for implementation of the axial transmission (AT) method is developed, so as to achieve precise measurement of the speed of sound (SOS) in the cortex (cSOS) of human long bone. The advantages of our QUS instrument are the following: (i) it is equipped with a cortical bone surface-morphology detection system to correct the ultrasound transmission distance, which should be necessary for AT measurement of long bone covered by soft tissue of non-uniform thickness; and (ii) ultrasound with a relatively high frequency of 3 MHz is employed, enabling thickness-independent cSOS measurement even for the thin cortex by preventing guide wave generation. The reliability of the proposed AT measurement system is confirmed through comparison with the well-established direct transmission (DT) method. The cSOS in human long bone is found to exhibit considerable direction-dependent anisotropy; the axial cSOS (3870 ± 66 m/s) is the highest, followed by the tangential (3411 ± 94 m/s) and radial (3320 ± 85 m/s) cSOSs. The degree of apatite orientation exhibits the same order, despite the unchanged bone mineral density. Multiple regression analysis reveals that the cSOS of human long bone strongly reflects the apatite orientation. The cSOS determined by the AT method is positively correlated with that determined by the DT method and sensitively reflects the apatite orientation variation, indicating the validity of the AT instrument developed in this study. Our instrument will be beneficial for noninvasive evaluation of the material integrity of the human long-bone cortex, as determined by apatite c-axis orientation along the axial direction.
Publisher	Elsevier
Source Title	Bone
Volume (Issue)	127
Page	82-90
Date of Issued	2019-10-01
Language	English
Handle URL	https://hdl.handle.net/11094/89815
PISSN	87563282
NCID	AA10506985
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1016/j.bone.2019.05.034
Access Rights	open access
CopyRight	This article is licensed under a Creative Commons Attribution 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCMI Type	Text
DCTERMS.bibliographicCitation	Bone. 2019, 127, p. 82-90
DC.title	Quantitative ultrasound (QUS) axial transmission method reflects anisotropy in micro-arrangement of apatite crystallites in human long bones: A study with 3-MHz-frequency ultrasound
DC.creator	Ishimoto, Takuya
	Suetoshi, Ryoichi
	Cretin, Dorian
	Hagihara, Koji
	Hashimoto, Jun
	Kobayashi, Akio
	Nakano, Takayoshi
DC.publisher	Elsevier
DC.language' scheme='DCTERMS.RFC1766	English
DC.type' scheme='DCTERMS.DCMIType	Text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2019-10-01
DC.identifier	https://doi.org/10.1016/j.bone.2019.05.034
DC.subject	Anisotropy
	Apatite orientation
	Bone quality
	Leaky surface wave
	Speed of sound (SOS)
DC.description	Ishimoto T., Suetoshi R., Cretin D., et al. Quantitative ultrasound (QUS) axial transmission method reflects anisotropy in micro-arrangement of apatite crystallites in human long bones: A study with 3-MHz-frequency ultrasound. Bone, 127, 82. https://doi.org/10.1016/j.bone.2019.05.034.
DCTERMS.abstract	Anisotropic arrangement of apatite crystallites, i.e., preferential orientation of the apatite c-axis, is known to be an important bone quality parameter that governs the mechanical properties. However, noninvasive evaluation of apatite orientation has not been achieved to date. The present paper reports the potential of quantitative ultrasound (QUS) for noninvasive evaluation of the degree of apatite orientation in human bone for the first time. A novel QUS instrument for implementation of the axial transmission (AT) method is developed, so as to achieve precise measurement of the speed of sound (SOS) in the cortex (cSOS) of human long bone. The advantages of our QUS instrument are the following: (i) it is equipped with a cortical bone surface-morphology detection system to correct the ultrasound transmission distance, which should be necessary for AT measurement of long bone covered by soft tissue of non-uniform thickness; and (ii) ultrasound with a relatively high frequency of 3 MHz is employed, enabling thickness-independent cSOS measurement even for the thin cortex by preventing guide wave generation. The reliability of the proposed AT measurement system is confirmed through comparison with the well-established direct transmission (DT) method. The cSOS in human long bone is found to exhibit considerable direction-dependent anisotropy; the axial cSOS (3870 ± 66 m/s) is the highest, followed by the tangential (3411 ± 94 m/s) and radial (3320 ± 85 m/s) cSOSs. The degree of apatite orientation exhibits the same order, despite the unchanged bone mineral density. Multiple regression analysis reveals that the cSOS of human long bone strongly reflects the apatite orientation. The cSOS determined by the AT method is positively correlated with that determined by the DT method and sensitively reflects the apatite orientation variation, indicating the validity of the AT instrument developed in this study. Our instrument will be beneficial for noninvasive evaluation of the material integrity of the human long-bone cortex, as determined by apatite c-axis orientation along the axial direction.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	89815
citation_title	Quantitative ultrasound (QUS) axial transmission method reflects anisotropy in micro-arrangement of apatite crystallites in human long bones: A study with 3-MHz-frequency ultrasound
citation_author	Ishimoto, Takuya
	Suetoshi, Ryoichi
	Cretin, Dorian
	Hagihara, Koji
	Hashimoto, Jun
	Kobayashi, Akio
	Nakano, Takayoshi
citation_publisher	Elsevier
citation_language	English
citation_date	2019-10-01
citation_journal_title	Bone
citation_volume	127
citation_firstpage	82
citation_lastpage	90
citation_doi	https://doi.org/10.1016/j.bone.2019.05.034
citation_public_url	https://hdl.handle.net/11094/89815

Quantitative ultrasound (QUS) axial transmission method reflects anisotropy in micro-arrangement of apatite crystallites in human long bones: A study with 3-MHz-frequency ultrasound

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