Development of bifunctional oriented bioactive glass/poly(lactic acid) composite scaffolds to control osteoblast alignment and proliferation

Lee, Sungho; Matsugaki, Aira; Kasuga, Toshihiro et al.

Journal of Biomedical Materials Research - Part A, 2019, 107(5), 1031-1041

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Identifier to cite or link to this item: https://hdl.handle.net/11094/89821

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Title
Development of bifunctional oriented bioactive glass/poly(lactic acid) composite scaffolds to control osteoblast alignment and proliferation
Creator
NRID
1000020850001 1000020850001
CreatorName
Lee, Sungho
NRID
1000010592529 1000010592529
ORCID
0000-0002-8427-7124 0000-0002-8427-7124
researchmap permalink
aira aira
Scopus Author ID
24172720900 24172720900
CreatorName
Matsugaki, Aira
NRID
1000030233729 1000030233729
CreatorName
Kasuga, Toshihiro
NRID
1000030243182 1000030243182
ORCID
0000-0001-8052-1698 0000-0001-8052-1698
researchmap permalink
read0013987 read0013987
Scopus Author ID
7403896013 7403896013
CreatorName
Nakano, Takayoshi
Description
Lee S., Matsugaki A., Kasuga T., et al. Development of bifunctional oriented bioactive glass/poly(lactic acid) composite scaffolds to control osteoblast alignment and proliferation. Journal of Biomedical Materials Research - Part A, 107, 5, 1031. https://doi.org/10.1002/jbm.a.36619.
Abstract
During the bone regeneration process, the anisotropic microstructure of bone tissue (bone quality) recovers much later than bone mass (bone quantity), resulting in severe mechanical dysfunction in the bone. Hence, restoration of bone microstructure in parallel with bone mass is necessary for ideal bone tissue regeneration; for this, development of advanced bifunctional biomaterials, which control both the quality and quantity in regenerated bone, is required. We developed novel oriented bioactive glass/poly(lactic acid) composite scaffolds by introducing an effective methodology for controlling cell alignment and proliferation, which play important roles for achieving bone anisotropy and bone mass, respectively. Our strategy is to manipulate the cell alignment and proliferation by the morphological control of the scaffolds in combination with controlled ion release from bioactive glasses. We quantitatively controlled the morphology of fibermats containing bioactive glasses by electrospinning, which successfully induced cell alignment along the fibermats. Also, the substitution of CaO in Bioglass®(45S5) with MgO and SrO improved osteoblast proliferation, indicating that dissolved Mg 2+ and Sr 2+ ions promoted cell adhesion and proliferation. Our results indicate that the fibermats developed in this work are candidates for the scaffolds to bone tissue regeneration that enable recovery of both bone quality and bone quantity. © 2019 The Authors. journal Of Biomedical Materials Research Part A Published By Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 1031–1041, 2019.
Publisher
John Wiley and Sons
Source Title
Journal of Biomedical Materials Research - Part A
Volume (Issue)
107(5)
Page
1031-1041
Date of Issued
2019-01-24
Language
English
Handle URL
https://hdl.handle.net/11094/89821
PISSN
15493296
eISSN
15524965
NCID
AA11881516
Relation.isIdenticalTo
DOI (Publisher Version)
https://doi.org/10.1002/jbm.a.36619
Access Rights
open access
CopyRight
This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
oaire:version
Version of Record
Category
学術雑誌論文 Journal Article