Dynamic collision behavior between osteoblasts and tumor cells regulates the disordered arrangement of collagen fiber/apatite crystals in metastasized bone

Matsugaki, Aira; Harada, Tatsuki; Kimura, Yumi et al.

International Journal of Molecular Sciences, 2018, 19(11), 3474

Number of Access:395（2025-07-27 15:50 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/89828

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Title
Dynamic collision behavior between osteoblasts and tumor cells regulates the disordered arrangement of collagen fiber/apatite crystals in metastasized bone
Creator
NRID
1000010592529 1000010592529
ORCID
0000-0002-8427-7124 0000-0002-8427-7124
researchmap permalink
aira aira
Scopus Author ID
24172720900 24172720900
CreatorName
Matsugaki, Aira
CreatorName
Harada, Tatsuki
CreatorName
Kimura, Yumi
CreatorName
Sekita, Aiko
NRID
1000030243182 1000030243182
ORCID
0000-0001-8052-1698 0000-0001-8052-1698
researchmap permalink
read0013987 read0013987
Scopus Author ID
7403896013 7403896013
CreatorName
Nakano, Takayoshi
Subject
Bone metastasis
Bone microstructure
Cell arrangement
Collagen/apatite
Description
Matsugaki A., Harada T., Kimura Y., et al. Dynamic collision behavior between osteoblasts and tumor cells regulates the disordered arrangement of collagen fiber/apatite crystals in metastasized bone. International Journal of Molecular Sciences, 19, 11, 3474. https://doi.org/10.3390/ijms19113474.
Abstract
Bone metastasis is one of the most intractable bone diseases; it is accompanied with a severe mechanical dysfunction of bone tissue. We recently discovered that the disorganized collagen/apatite microstructure in cancer-bearing bone is a dominant determinant of the disruption of bone mechanical function; disordered osteoblast arrangement was found to be one of the principal determinants of the deteriorated collagen/apatite microstructure. However, the precise molecular mechanisms regulating the disordered osteoblast arrangement triggered by cancer invasion are not yet understood. Herein, we demonstrate a significant disorganization of bone tissue anisotropy in metastasized bone in our novel ex vivo metastasis model. Further, we propose a novel mechanism underlying the disorganization of a metastasized bone matrix: A dynamic collision behavior between tumor cells and osteoblasts disturbs the osteoblast arrangement along the collagen substrate.
Publisher
MDPI
Source Title
International Journal of Molecular Sciences
Volume (Issue)
19(11)
Page
3474
Date of Issued
2018-11-05
Language
English
Handle URL
https://hdl.handle.net/11094/89828
PISSN
16616596
eISSN
14220067
Relation.isIdenticalTo
DOI (Publisher Version)
https://doi.org/10.3390/ijms19113474
Access Rights
open access
CopyRight
This article is licensed under a Creative Commons Attribution 4.0 International License.
oaire:version
Version of Record
Category
学術雑誌論文 Journal Article