Effects of long-term cigarette smoke exposure on bone metabolism, structure, and quality in a mouse model of emphysema

Sasaki, Mamoru; Chubachi, Shotaro; Kameyama, Naofumi; Sato, Minako; Haraguchi, Mizuha; Miyazaki, Masaki; Takahashi, Saeko; Nakano, Takayoshi; Kuroda, Yukiko; Betsuyaku, Tomoko; Matsuo, Koichi

doi:https://doi.org/10.1371/journal.pone.0191611

Effects of long-term cigarette smoke exposure on bone metabolism, structure, and quality in a mouse model of emphysema

Sasaki, Mamoru; Chubachi, Shotaro; Kameyama, Naofumi et al.

PLoS ONE, 2018, 13(1), e0191611

Number of Access:697（2025-08-21 04:36 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/89835

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Title	Effects of long-term cigarette smoke exposure on bone metabolism, structure, and quality in a mouse model of emphysema
Creator	NRID 1000090573311 1000090573311 CreatorName Sasaki, Mamoru
	NRID 1000090464867 1000090464867 CreatorName Chubachi, Shotaro
	CreatorName Kameyama, Naofumi
	CreatorName Sato, Minako
	CreatorName Haraguchi, Mizuha
	CreatorName Miyazaki, Masaki
	CreatorName Takahashi, Saeko
	NRID 1000030243182 1000030243182 ORCID 0000-0001-8052-1698 0000-0001-8052-1698 researchmap permalink read0013987 read0013987 Scopus Author ID 7403896013 7403896013 CreatorName Nakano, Takayoshi
	NRID 1000070455343 1000070455343 CreatorName Kuroda, Yukiko
	NRID 1000060333605 1000060333605 CreatorName Betsuyaku, Tomoko
	NRID 1000040229422 1000040229422 CreatorName Matsuo, Koichi
Description	Effects of long-term cigarette smoke exposure on bone metabolism, structure, and quality in a mouse model of emphysema. Mamoru Sasaki et al. PLOS ONE. 2018. 1(30) doi.org/10.1371/journal.pone.0191611
Abstract	Smoking is a common risk factor for both chronic obstructive pulmonary disease (COPD) and osteoporosis. In patients with COPD, severe emphysema is a risk factor for vertebral fracture; however, the effects of smoking or emphysema on bone health remain largely unknown. We report bone deterioration in a mouse model of emphysema induced by nose-only cigarette smoke (CS) exposure. Unexpectedly, short-term exposure for 4-weeks decreased bone turnover and increased bone volume in mice. However, prolonged exposure for 20- and 40-weeks reversed the effects from suppression to promotion of bone resorption. This long-term CS exposure increased osteoclast number and impaired bone growth, while it increased bone volume. Strikingly, long-term CS exposure deteriorated bone quality of the lumbar vertebrae as illustrated by disorientation of collagen fibers and the biological apatite c-axis. This animal model may provide a better understanding of the mechanisms underlying the deterioration of bone quality in pulmonary emphysema caused by smoking.
Publisher	Public Library of Science
Source Title	PLoS ONE
Volume (Issue)	13(1)
Page	e0191611
Date of Issued	2018-01-30
Language	English
Handle URL	https://hdl.handle.net/11094/89835
eISSN	19326203
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1371/journal.pone.0191611
Access Rights	open access
CopyRight	This article is licensed under a Creative Commons Attribution 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCMI Type	Text
DCTERMS.bibliographicCitation	PLoS ONE. 2018, 13(1), p. e0191611
DC.title	Effects of long-term cigarette smoke exposure on bone metabolism, structure, and quality in a mouse model of emphysema
DC.creator	Sasaki, Mamoru
	Chubachi, Shotaro
	Kameyama, Naofumi
	Sato, Minako
	Haraguchi, Mizuha
	Miyazaki, Masaki
	Takahashi, Saeko
	Nakano, Takayoshi
	Kuroda, Yukiko
	Betsuyaku, Tomoko
	Matsuo, Koichi
DC.publisher	Public Library of Science
DC.language' scheme='DCTERMS.RFC1766	English
DC.type' scheme='DCTERMS.DCMIType	Text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2018-01-30
DC.identifier	https://doi.org/10.1371/journal.pone.0191611
DC.description	Effects of long-term cigarette smoke exposure on bone metabolism, structure, and quality in a mouse model of emphysema. Mamoru Sasaki et al. PLOS ONE. 2018. 1(30) doi.org/10.1371/journal.pone.0191611
DCTERMS.abstract	Smoking is a common risk factor for both chronic obstructive pulmonary disease (COPD) and osteoporosis. In patients with COPD, severe emphysema is a risk factor for vertebral fracture; however, the effects of smoking or emphysema on bone health remain largely unknown. We report bone deterioration in a mouse model of emphysema induced by nose-only cigarette smoke (CS) exposure. Unexpectedly, short-term exposure for 4-weeks decreased bone turnover and increased bone volume in mice. However, prolonged exposure for 20- and 40-weeks reversed the effects from suppression to promotion of bone resorption. This long-term CS exposure increased osteoclast number and impaired bone growth, while it increased bone volume. Strikingly, long-term CS exposure deteriorated bone quality of the lumbar vertebrae as illustrated by disorientation of collagen fibers and the biological apatite c-axis. This animal model may provide a better understanding of the mechanisms underlying the deterioration of bone quality in pulmonary emphysema caused by smoking.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	89835
citation_title	Effects of long-term cigarette smoke exposure on bone metabolism, structure, and quality in a mouse model of emphysema
citation_author	Sasaki, Mamoru
	Chubachi, Shotaro
	Kameyama, Naofumi
	Sato, Minako
	Haraguchi, Mizuha
	Miyazaki, Masaki
	Takahashi, Saeko
	Nakano, Takayoshi
	Kuroda, Yukiko
	Betsuyaku, Tomoko
	Matsuo, Koichi
citation_publisher	Public Library of Science
citation_language	English
citation_date	2018-01-30
citation_journal_title	PLoS ONE
citation_volume	13
citation_issue	1
citation_firstpage	e0191611
citation_doi	https://doi.org/10.1371/journal.pone.0191611
citation_public_url	https://hdl.handle.net/11094/89835

Effects of long-term cigarette smoke exposure on bone metabolism, structure, and quality in a mouse model of emphysema

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