Salivary metabolic signatures of carotid atherosclerosis in patients with type 2 diabetes hospitalized for treatment

Sakanaka, Akito; Katakami, Naoto; Furuno, Masahiro; Nishizawa, Hitoshi; Omori, Kazuo; Taya, Naohiro; Ishikawa, Asuka; Mayumi, Shota; Inoue, Moe; Isomura, Emiko; Amano, Atsuo; Shimomura, Iichiro; Fukusaki, Eiichiro; Kuboniwa, Masae

doi:https://doi.org/10.3389/fmolb.2022.1074285

Salivary metabolic signatures of carotid atherosclerosis in patients with type 2 diabetes hospitalized for treatment

Sakanaka, Akito; Katakami, Naoto; Furuno, Masahiro et al.

Frontiers in Molecular Biosciences, 2022, 9, 1074285

Number of Access:2,092（2025-07-18 10:08 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/89884

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Title	Salivary metabolic signatures of carotid atherosclerosis in patients with type 2 diabetes hospitalized for treatment
Creator	NRID 1000090815557 1000090815557 researchmap permalink sknk1022 sknk1022 Scopus Author ID 56814868300 56814868300 ORCID 0000-0001-9733-6886 0000-0001-9733-6886 CreatorName Sakanaka, Akito
	NRID 1000010403049 1000010403049 researchmap permalink naoto.katakami naoto.katakami Scopus Author ID 7003392840 7003392840 CreatorName Katakami, Naoto
	CreatorName Furuno, Masahiro
	NRID 1000020379259 1000020379259 researchmap permalink Hitoshi_Nishizawa Hitoshi_Nishizawa Scopus Author ID 7102282682 7102282682 CreatorName Nishizawa, Hitoshi
	CreatorName Omori, Kazuo
	CreatorName Taya, Naohiro
	CreatorName Ishikawa, Asuka
	NRID 1000010964851 1000010964851 CreatorName Mayumi, Shota
	CreatorName Inoue, Moe
	NRID 1000070397701 1000070397701 researchmap permalink read0076452 read0076452 Scopus Author ID 55667115400 55667115400 CreatorName Isomura, Emiko Creator.Alternative Tanaka, Emiko
	NRID 1000050193024 1000050193024 researchmap permalink read0014208 read0014208 Scopus Author ID 7101649822 7101649822 CreatorName Amano, Atsuo
	NRID 1000060346145 1000060346145 researchmap permalink shimomura_i shimomura_i Scopus Author ID 7006715546 7006715546 ORCID 0000-0002-0851-9603 0000-0002-0851-9603 CreatorName Shimomura, Iichiro
	NRID 1000040273594 1000040273594 ORCID 0000-0003-3069-5547 0000-0003-3069-5547 researchmap permalink fukusaki-eiichiro fukusaki-eiichiro Scopus Author ID 35473325000 35473325000 CreatorName Fukusaki, Eiichiro
	NRID 1000000303983 1000000303983 ORCID 0000-0002-3332-2431 0000-0002-3332-2431 researchmap permalink MasaeKuboniwa_URL MasaeKuboniwa_URL Scopus Author ID 56089471500 56089471500 CreatorName Kuboniwa, Masae
Subject	atherosclerosis
	carotid intima-media thickness (IMT)
	diabetes
	metabolomics
	oxidative stress
	saliva
Description	Sakanaka A, Katakami N, Furuno M, Nishizawa H, Omori K, Taya N, Ishikawa A, Mayumi S, Inoue M, Tanaka Isomura E, Amano A, Shimomura I, Fukusaki E and Kuboniwa M (2022) Salivary metabolic signatures of carotid atherosclerosis in patients with type 2 diabetes hospitalized for treatment. Front. Mol. Biosci. 9:1074285. doi: 10.3389/fmolb.2022.1074285
Abstract	Atherosclerosis is a life-threatening disease associated with morbidity and mortality in patients with type 2 diabetes (T2D). This study aimed to characterize a salivary signature of atherosclerosis based on evaluation of carotid intima-media thickness (IMT) to develop a non-invasive predictive tool for diagnosis and disease follow-up. Metabolites in saliva and plasma samples collected at admission and after treatment from 25 T2D patients hospitalized for 2 weeks to undergo medical treatment for diabetes were comprehensively profiled using metabolomic profiling with gas chromatography-mass spectrometry. Orthogonal partial least squares analysis, used to explore the relationships of IMT with clinical markers and plasma and salivary metabolites, showed that the top predictors for IMT included salivary allantoin and 1,5-anhydroglucitol (1,5-AG) at both the baseline examination at admission and after treatment. Furthermore, though treatment induced alterations in salivary levels of allantoin and 1,5-AG, it did not modify the association between IMT and these metabolites (pinteraction > 0.05), and models with these metabolites combined yielded satisfactory diagnostic accuracy for the high IMT group even after treatment (area under curve = 0.819). Collectively, this salivary metabolite combination may be useful for non-invasive identification of T2D patients with a higher atherosclerotic burden in clinical settings.
Publisher	Frontiers Media
Source Title	Frontiers in Molecular Biosciences
Volume (Issue)	9
Page	1074285
Date of Issued	2022-12-21
Language	English
Handle URL	https://hdl.handle.net/11094/89884
eISSN	2296889X
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.3389/fmolb.2022.1074285
Access Rights	open access
CopyRight	This article is licensed under a Creative Commons Attribution 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCMI Type	Text
DCTERMS.bibliographicCitation	Frontiers in Molecular Biosciences. 2022, 9, p. 1074285
DC.title	Salivary metabolic signatures of carotid atherosclerosis in patients with type 2 diabetes hospitalized for treatment
DC.creator	Sakanaka, Akito
	Katakami, Naoto
	Furuno, Masahiro
	Nishizawa, Hitoshi
	Omori, Kazuo
	Taya, Naohiro
	Ishikawa, Asuka
	Mayumi, Shota
	Inoue, Moe
	Isomura, Emiko
	Amano, Atsuo
	Shimomura, Iichiro
	Fukusaki, Eiichiro
	Kuboniwa, Masae
DC.creator	Tanaka, Emiko
DC.publisher	Frontiers Media
DC.language' scheme='DCTERMS.RFC1766	English
DC.type' scheme='DCTERMS.DCMIType	Text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2022-12-21
DC.identifier	https://doi.org/10.3389/fmolb.2022.1074285
DC.subject	atherosclerosis
	carotid intima-media thickness (IMT)
	diabetes
	metabolomics
	oxidative stress
	saliva
DC.description	Sakanaka A, Katakami N, Furuno M, Nishizawa H, Omori K, Taya N, Ishikawa A, Mayumi S, Inoue M, Tanaka Isomura E, Amano A, Shimomura I, Fukusaki E and Kuboniwa M (2022) Salivary metabolic signatures of carotid atherosclerosis in patients with type 2 diabetes hospitalized for treatment. Front. Mol. Biosci. 9:1074285. doi: 10.3389/fmolb.2022.1074285
DCTERMS.abstract	Atherosclerosis is a life-threatening disease associated with morbidity and mortality in patients with type 2 diabetes (T2D). This study aimed to characterize a salivary signature of atherosclerosis based on evaluation of carotid intima-media thickness (IMT) to develop a non-invasive predictive tool for diagnosis and disease follow-up. Metabolites in saliva and plasma samples collected at admission and after treatment from 25 T2D patients hospitalized for 2 weeks to undergo medical treatment for diabetes were comprehensively profiled using metabolomic profiling with gas chromatography-mass spectrometry. Orthogonal partial least squares analysis, used to explore the relationships of IMT with clinical markers and plasma and salivary metabolites, showed that the top predictors for IMT included salivary allantoin and 1,5-anhydroglucitol (1,5-AG) at both the baseline examination at admission and after treatment. Furthermore, though treatment induced alterations in salivary levels of allantoin and 1,5-AG, it did not modify the association between IMT and these metabolites (pinteraction > 0.05), and models with these metabolites combined yielded satisfactory diagnostic accuracy for the high IMT group even after treatment (area under curve = 0.819). Collectively, this salivary metabolite combination may be useful for non-invasive identification of T2D patients with a higher atherosclerotic burden in clinical settings.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	89884
citation_title	Salivary metabolic signatures of carotid atherosclerosis in patients with type 2 diabetes hospitalized for treatment
citation_author	Sakanaka, Akito
	Katakami, Naoto
	Furuno, Masahiro
	Nishizawa, Hitoshi
	Omori, Kazuo
	Taya, Naohiro
	Ishikawa, Asuka
	Mayumi, Shota
	Inoue, Moe
	Isomura, Emiko
	Amano, Atsuo
	Shimomura, Iichiro
	Fukusaki, Eiichiro
	Kuboniwa, Masae
citation_publisher	Frontiers Media
citation_language	English
citation_date	2022-12-21
citation_journal_title	Frontiers in Molecular Biosciences
citation_volume	9
citation_firstpage	1074285
citation_doi	https://doi.org/10.3389/fmolb.2022.1074285
citation_public_url	https://hdl.handle.net/11094/89884

Salivary metabolic signatures of carotid atherosclerosis in patients with type 2 diabetes hospitalized for treatment

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