Effects of autogenous bone graft on mass and quality of trabecular bone in Ti-6Al-4V spinal cage fabricated with electron beam melting

Takahashi, Hiroyuki; Ishimoto, Takuya; Inoue, Takayuki; Kimura, Hiroomi; Uetsuki, Keita; Okuda, Natsuki; Nakanishi, Yohei; Oh, Jong Yeong; Ito, Manabu; Nakashima, Yoshio; Hanawa, Takao; Nakano, Takayoshi

doi:https://doi.org/10.2320/matertrans.M2018329

Effects of autogenous bone graft on mass and quality of trabecular bone in Ti-6Al-4V spinal cage fabricated with electron beam melting

Takahashi, Hiroyuki; Ishimoto, Takuya; Inoue, Takayuki et al.

Materials Transactions, 2019, 60(1), 144-148

Number of Access:1,288（2025-07-18 09:59 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/89901

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Title	Effects of autogenous bone graft on mass and quality of trabecular bone in Ti-6Al-4V spinal cage fabricated with electron beam melting
Creator	CreatorName Takahashi, Hiroyuki
	NRID 1000050508835 1000050508835 ORCID 0000-0003-0081-0591 0000-0003-0081-0591 researchmap permalink i_taku i_taku Scopus Author ID 35310484700 35310484700 CreatorName Ishimoto, Takuya
	CreatorName Inoue, Takayuki
	CreatorName Kimura, Hiroomi
	CreatorName Uetsuki, Keita
	CreatorName Okuda, Natsuki
	CreatorName Nakanishi, Yohei
	CreatorName Oh, Jong Yeong
	NRID 1000000271677 1000000271677 CreatorName Ito, Manabu
	CreatorName Nakashima, Yoshio
	NRID 1000090142736 1000090142736 CreatorName Hanawa, Takao
	NRID 1000030243182 1000030243182 ORCID 0000-0001-8052-1698 0000-0001-8052-1698 researchmap permalink read0013987 read0013987 Scopus Author ID 7403896013 7403896013 CreatorName Nakano, Takayoshi
Subject	Bone quality
	Collagen/apatite orientation
	Intervertebral cage
	Trabecular anisotropy
	Trabecular bone
Description	Takahashi H., Ishimoto T., Inoue T., et al. Effects of autogenous bone graft on mass and quality of trabecular bone in Ti-6Al-4V spinal cage fabricated with electron beam melting. Materials Transactions 60, 144 (2019); https://doi.org/10.2320/matertrans.M2018329.
Abstract	A spinal cage is one of the primary spinal devices used for the treatment of spinal diseases such as lumbar spondylolisthesis. Since it is set in the intervertebral space that causes instability to promote the fusion of the adjacent vertebral bodies, it requires the early induction of healthy bones. For this reason, in most cases, an autogenous bone extracted from the patient’s ilium is implanted in the interior of the cage to stimulate bone formation. However, collecting autogenous bone involves secondary surgery and several clinical problems such as pain in the part from which it is collected. Additionally, the effect of the autogenous bone graft itself has not been sufficiently studied yet. Moreover, the mechanical functions of trabecular bones in a vertebral body are governed by the anisotropic structure of the trabeculae and the preferential orientation of the apatite/collagen in a trabecula with respect to the principal stress. Despite this fact, after the implantation of the cage, the mass of the bones is evaluated with soft X-ray photography, which does not guarantee an accurate measurement of bone functions. In this study, the effect of the autogenous bone graft on the spinal cage was verified based on structural anisotropy of trabecular bones and the preferential orientation of apatite/collagen in a trabecula using sheep. The autogenous bone graft demonstrated a significant effect on the increase of bone mass and anisotropy of the trabecular structure. However, compared to the trabecular anisotropy of normal parts, the anisotropy of the trabecular structure and apatite c-axis orientation of the parts with autogenous bone graft were considerably lower, indicating a minimal effect of the autogenous bone graft. Therefore, it was suggested that early stabilization of the spinal cage requires another strategy that rapidly forms the unique hierarchical anisotropic structure of trabecular bones.
Publisher	The Japan Institute of Metals and Materials
Source Title	Materials Transactions
Volume (Issue)	60(1)
Page	144-148
Date of Issued	2019-01-01
Language	English
Handle URL	https://hdl.handle.net/11094/89901
PISSN	13459678
eISSN	13475320
NCID	AA1151294X
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.2320/matertrans.M2018329
Access Rights	open access
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCMI Type	Text
DCTERMS.bibliographicCitation	Materials Transactions. 2019, 60(1), p. 144-148
DC.title	Effects of autogenous bone graft on mass and quality of trabecular bone in Ti-6Al-4V spinal cage fabricated with electron beam melting
DC.creator	Takahashi, Hiroyuki
	Ishimoto, Takuya
	Inoue, Takayuki
	Kimura, Hiroomi
	Uetsuki, Keita
	Okuda, Natsuki
	Nakanishi, Yohei
	Oh, Jong Yeong
	Ito, Manabu
	Nakashima, Yoshio
	Hanawa, Takao
	Nakano, Takayoshi
DC.publisher	The Japan Institute of Metals and Materials
DC.language' scheme='DCTERMS.RFC1766	English
DC.type' scheme='DCTERMS.DCMIType	Text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2019-01-01
DC.identifier	https://doi.org/10.2320/matertrans.M2018329
DC.subject	Bone quality
	Collagen/apatite orientation
	Intervertebral cage
	Trabecular anisotropy
	Trabecular bone
DC.description	Takahashi H., Ishimoto T., Inoue T., et al. Effects of autogenous bone graft on mass and quality of trabecular bone in Ti-6Al-4V spinal cage fabricated with electron beam melting. Materials Transactions 60, 144 (2019); https://doi.org/10.2320/matertrans.M2018329.
DCTERMS.abstract	A spinal cage is one of the primary spinal devices used for the treatment of spinal diseases such as lumbar spondylolisthesis. Since it is set in the intervertebral space that causes instability to promote the fusion of the adjacent vertebral bodies, it requires the early induction of healthy bones. For this reason, in most cases, an autogenous bone extracted from the patient’s ilium is implanted in the interior of the cage to stimulate bone formation. However, collecting autogenous bone involves secondary surgery and several clinical problems such as pain in the part from which it is collected. Additionally, the effect of the autogenous bone graft itself has not been sufficiently studied yet. Moreover, the mechanical functions of trabecular bones in a vertebral body are governed by the anisotropic structure of the trabeculae and the preferential orientation of the apatite/collagen in a trabecula with respect to the principal stress. Despite this fact, after the implantation of the cage, the mass of the bones is evaluated with soft X-ray photography, which does not guarantee an accurate measurement of bone functions. In this study, the effect of the autogenous bone graft on the spinal cage was verified based on structural anisotropy of trabecular bones and the preferential orientation of apatite/collagen in a trabecula using sheep. The autogenous bone graft demonstrated a significant effect on the increase of bone mass and anisotropy of the trabecular structure. However, compared to the trabecular anisotropy of normal parts, the anisotropy of the trabecular structure and apatite c-axis orientation of the parts with autogenous bone graft were considerably lower, indicating a minimal effect of the autogenous bone graft. Therefore, it was suggested that early stabilization of the spinal cage requires another strategy that rapidly forms the unique hierarchical anisotropic structure of trabecular bones.
DC.format	89901
citation_title	Effects of autogenous bone graft on mass and quality of trabecular bone in Ti-6Al-4V spinal cage fabricated with electron beam melting
citation_author	Takahashi, Hiroyuki
	Ishimoto, Takuya
	Inoue, Takayuki
	Kimura, Hiroomi
	Uetsuki, Keita
	Okuda, Natsuki
	Nakanishi, Yohei
	Oh, Jong Yeong
	Ito, Manabu
	Nakashima, Yoshio
	Hanawa, Takao
	Nakano, Takayoshi
citation_publisher	The Japan Institute of Metals and Materials
citation_language	English
citation_date	2019-01-01
citation_journal_title	Materials Transactions
citation_volume	60
citation_issue	1
citation_firstpage	144
citation_lastpage	148
citation_doi	https://doi.org/10.2320/matertrans.M2018329
citation_public_url	https://hdl.handle.net/11094/89901

Effects of autogenous bone graft on mass and quality of trabecular bone in Ti-6Al-4V spinal cage fabricated with electron beam melting

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