Antibacterial Cu-Doped HA/TiO₂ Bioactive Ceramic Composite Coating with Enhanced Adhesion on Pure Ti

Yang, Jiawei; Li, Qiang; Li, Junjie; Yang, Jinshuai; Zhang, Ran; Niinomi, Mitsuo; Nakano, Takayoshi

doi:https://doi.org/10.1007/s11665-022-07541-6

Antibacterial Cu-Doped HA/TiO₂ Bioactive Ceramic Composite Coating with Enhanced Adhesion on Pure Ti

Yang, Jiawei; Li, Qiang; Li, Junjie et al.

Journal of Materials Engineering and Performance, 2022, 32(14), 6151-6159

Number of Access:635（2025-08-21 04:37 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/89906

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Title	Antibacterial Cu-Doped HA/TiO₂ Bioactive Ceramic Composite Coating with Enhanced Adhesion on Pure Ti
Creator	CreatorName Yang, Jiawei
	CreatorName Li, Qiang
	CreatorName Li, Junjie
	CreatorName Yang, Jinshuai
	CreatorName Zhang, Ran
	NRID 1000050126942 1000050126942 CreatorName Niinomi, Mitsuo
	NRID 1000030243182 1000030243182 ORCID 0000-0001-8052-1698 0000-0001-8052-1698 researchmap permalink read0013987 read0013987 Scopus Author ID 7403896013 7403896013 CreatorName Nakano, Takayoshi
Subject	adhesion
	antibacterial properties
	Cu-doped hydroxyapatite coating
	electrochemical deposition
	TiO₂ nanopore
Description	This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1007/s11665-022-07541-6.
Abstract	Cu-doped hydroxyapatite (HA)/TiO₂ (CuHA/TiO₂) bioactive ceramic composite coatings were prepared on Ti surfaces using an electrochemical method to enhance their adhesion and antibacterial properties. The obtained coatings were characterized by scanning electron microscopy, x-ray diffraction, and x-ray photoelectron spectroscopy, while their adhesion was measured using a scratch test. The maximum adhesion between the TiO₂ layer and the substrate was 39.8 ± 2.6 N at an anodizing voltage of 180 V. Subsequently, the CuHA coatings were successfully deposited on the TiO₂ layers and grown outward along TiO₂ pores (during this process, Cu atoms are doped into the HA structure in the form of Cu²⁺ ions). The CuHA adhesion to the TiO₂ layer was 26.3 ± 1.9 N, indicating that the TiO₂ interlayer significantly enhanced the bonding of CuHA to the substrate. Furthermore, the fabricated CuHA/TiO₂ coatings produced a strong antibacterial effect on Escherichia coli and Staphylococcus aureus species, exhibited high biocompatibility, and promoted the proliferation of MC₃T₃-E₁ cells.
Publisher	Springer
Source Title	Journal of Materials Engineering and Performance
Volume (Issue)	32(14)
Page	6151-6159
Date of Issued	2022-11-28
Language	English
Handle URL	https://hdl.handle.net/11094/89906
PISSN	10599495
eISSN	15441024
NCID	AA10850368
Relation.isVersionOf	DOI (Publisher Version) https://doi.org/10.1007/s11665-022-07541-6
Access Rights	open access
oaire:version	Accepted Manuscript
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCMI Type	Text
DCTERMS.bibliographicCitation	Journal of Materials Engineering and Performance. 2022, 32(14), p. 6151-6159
DC.title	Antibacterial Cu-Doped HA/TiO₂ Bioactive Ceramic Composite Coating with Enhanced Adhesion on Pure Ti
DC.creator	Yang, Jiawei
	Li, Qiang
	Li, Junjie
	Yang, Jinshuai
	Zhang, Ran
	Niinomi, Mitsuo
	Nakano, Takayoshi
DC.publisher	Springer
DC.language' scheme='DCTERMS.RFC1766	English
DC.type' scheme='DCTERMS.DCMIType	Text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2022-11-28
DC.identifier	https://doi.org/10.1007/s11665-022-07541-6
DC.subject	adhesion
	antibacterial properties
	Cu-doped hydroxyapatite coating
	electrochemical deposition
	TiO₂ nanopore
DC.description	This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1007/s11665-022-07541-6.
DCTERMS.abstract	Cu-doped hydroxyapatite (HA)/TiO₂ (CuHA/TiO₂) bioactive ceramic composite coatings were prepared on Ti surfaces using an electrochemical method to enhance their adhesion and antibacterial properties. The obtained coatings were characterized by scanning electron microscopy, x-ray diffraction, and x-ray photoelectron spectroscopy, while their adhesion was measured using a scratch test. The maximum adhesion between the TiO₂ layer and the substrate was 39.8 ± 2.6 N at an anodizing voltage of 180 V. Subsequently, the CuHA coatings were successfully deposited on the TiO₂ layers and grown outward along TiO₂ pores (during this process, Cu atoms are doped into the HA structure in the form of Cu²⁺ ions). The CuHA adhesion to the TiO₂ layer was 26.3 ± 1.9 N, indicating that the TiO₂ interlayer significantly enhanced the bonding of CuHA to the substrate. Furthermore, the fabricated CuHA/TiO₂ coatings produced a strong antibacterial effect on Escherichia coli and Staphylococcus aureus species, exhibited high biocompatibility, and promoted the proliferation of MC₃T₃-E₁ cells.
DC.format	89906
citation_title	Antibacterial Cu-Doped HA/TiO₂ Bioactive Ceramic Composite Coating with Enhanced Adhesion on Pure Ti
citation_author	Yang, Jiawei
	Li, Qiang
	Li, Junjie
	Yang, Jinshuai
	Zhang, Ran
	Niinomi, Mitsuo
	Nakano, Takayoshi
citation_publisher	Springer
citation_language	English
citation_date	2022-11-28
citation_journal_title	Journal of Materials Engineering and Performance
citation_volume	32
citation_issue	14
citation_firstpage	6151
citation_lastpage	6159
citation_doi	https://doi.org/10.1007/s11665-022-07541-6
citation_public_url	https://hdl.handle.net/11094/89906

Antibacterial Cu-Doped HA/TiO₂ Bioactive Ceramic Composite Coating with Enhanced Adhesion on Pure Ti

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