Effects of unloading by tail suspension on biological apatite crystallite alignment in mouse femur

Nakajima, Kosuke; Matsunaga, Satoru; Morioka, Toshiyuki; Nakano, Takayoshi; Abe, Shinichi; Furuya, Yoshitaka; Yajima, Yasutomo

doi:https://doi.org/10.4012/dmj.2019-187

Effects of unloading by tail suspension on biological apatite crystallite alignment in mouse femur

Nakajima, Kosuke; Matsunaga, Satoru; Morioka, Toshiyuki et al.

Dental Materials Journal, 2020, 39(4), 670-677

Number of Access:635（2025-08-21 04:37 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/89928

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Title	Effects of unloading by tail suspension on biological apatite crystallite alignment in mouse femur
Creator	CreatorName Nakajima, Kosuke
	NRID 1000070453751 1000070453751 CreatorName Matsunaga, Satoru
	CreatorName Morioka, Toshiyuki
	NRID 1000030243182 1000030243182 ORCID 0000-0001-8052-1698 0000-0001-8052-1698 researchmap permalink read0013987 read0013987 Scopus Author ID 7403896013 7403896013 CreatorName Nakano, Takayoshi
	NRID 1000040256300 1000040256300 CreatorName Abe, Shinichi
	NRID 1000080385179 1000080385179 CreatorName Furuya, Yoshitaka
	NRID 1000010183667 1000010183667 CreatorName Yajima, Yasutomo
Subject	Biological apatite crystallite alignment
	Bone mineral density (BMD)
	Bone quality
	Femur
	Hindlimb-unloading
Description	Nakajima K., Matsunaga S., Morioka T., et al. Effects of unloading by tail suspension on biological apatite crystallite alignment in mouse femur. Dental Materials Journal 39, 670 (2020); https://doi.org/10.4012/dmj.2019-187.
Abstract	The aim of this study was clarify the effects of reducing various functional pressures essential for the maintenance of bone homeostasis. Femoral bone mineral density (BMD) and biological apatite (BAp) crystallite alignment were measured in conventionally reared and hindlimb-unloaded mice. The femur was divided into 10 equal segments perpendicular to the longitudinal axis of the bone and measurements were performed on the cortical bone in the five segments closest to the midpoint of the femur. Significantly lower BMD and BAp alignment in the longitudinal (Z-axis) direction were observed in the hindlimb-unloaded group. The present findings suggest that unloading by tail suspension significantly decreases not only mouse femoral bone mass but also BAp crystallite alignment, although minimal uniaxial preferential alignment is retained.
Publisher	Japanese Society for Dental Materials and Devices
Source Title	Dental Materials Journal
Volume (Issue)	39(4)
Page	670-677
Date of Issued	2020-07-30
Language	English
Handle URL	https://hdl.handle.net/11094/89928
PISSN	02874547
eISSN	18811361
NCID	AA10443149
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.4012/dmj.2019-187
Access Rights	open access
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCMI Type	Text
DCTERMS.bibliographicCitation	Dental Materials Journal. 2020, 39(4), p. 670-677
DC.title	Effects of unloading by tail suspension on biological apatite crystallite alignment in mouse femur
DC.creator	Nakajima, Kosuke
	Matsunaga, Satoru
	Morioka, Toshiyuki
	Nakano, Takayoshi
	Abe, Shinichi
	Furuya, Yoshitaka
	Yajima, Yasutomo
DC.publisher	Japanese Society for Dental Materials and Devices
DC.language' scheme='DCTERMS.RFC1766	English
DC.type' scheme='DCTERMS.DCMIType	Text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2020-07-30
DC.identifier	https://doi.org/10.4012/dmj.2019-187
DC.subject	Biological apatite crystallite alignment
	Bone mineral density (BMD)
	Bone quality
	Femur
	Hindlimb-unloading
DC.description	Nakajima K., Matsunaga S., Morioka T., et al. Effects of unloading by tail suspension on biological apatite crystallite alignment in mouse femur. Dental Materials Journal 39, 670 (2020); https://doi.org/10.4012/dmj.2019-187.
DCTERMS.abstract	The aim of this study was clarify the effects of reducing various functional pressures essential for the maintenance of bone homeostasis. Femoral bone mineral density (BMD) and biological apatite (BAp) crystallite alignment were measured in conventionally reared and hindlimb-unloaded mice. The femur was divided into 10 equal segments perpendicular to the longitudinal axis of the bone and measurements were performed on the cortical bone in the five segments closest to the midpoint of the femur. Significantly lower BMD and BAp alignment in the longitudinal (Z-axis) direction were observed in the hindlimb-unloaded group. The present findings suggest that unloading by tail suspension significantly decreases not only mouse femoral bone mass but also BAp crystallite alignment, although minimal uniaxial preferential alignment is retained.
DC.format	89928
citation_title	Effects of unloading by tail suspension on biological apatite crystallite alignment in mouse femur
citation_author	Nakajima, Kosuke
	Matsunaga, Satoru
	Morioka, Toshiyuki
	Nakano, Takayoshi
	Abe, Shinichi
	Furuya, Yoshitaka
	Yajima, Yasutomo
citation_publisher	Japanese Society for Dental Materials and Devices
citation_language	English
citation_date	2020-07-30
citation_journal_title	Dental Materials Journal
citation_volume	39
citation_issue	4
citation_firstpage	670
citation_lastpage	677
citation_doi	https://doi.org/10.4012/dmj.2019-187
citation_public_url	https://hdl.handle.net/11094/89928

Effects of unloading by tail suspension on biological apatite crystallite alignment in mouse femur

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