Biomechanical effects of hyper-dynamic cerebrospinal fluid flow through the cerebral aqueduct in idiopathic normal pressure hydrocephalus patients

Maeda, Shusaku; Otani, Tomohiro; Yamada, Shigeki et al.

Journal of Biomechanics, 2023, 156, 111671

Number of Access:769（2025-08-28 20:55 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/92339

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Title
Biomechanical effects of hyper-dynamic cerebrospinal fluid flow through the cerebral aqueduct in idiopathic normal pressure hydrocephalus patients
Creator
CreatorName
Maeda, Shusaku
NRID
1000040778990 1000040778990
ORCID
0000-0002-6431-2703 0000-0002-6431-2703
researchmap permalink
bigvalley bigvalley
Scopus Author ID
55625962900 55625962900
CreatorName
Otani, Tomohiro
NRID
1000040422969 1000040422969
CreatorName
Yamada, Shigeki
NRID
1000020362733 1000020362733
CreatorName
Watanabe, Yoshiyuki
CreatorName
Ilik, Selin Yavuz
NRID
1000070240546 1000070240546
researchmap permalink
shigeo41010 shigeo41010
Scopus Author ID
7401983636 7401983636
CreatorName
Wada, Shigeo
Subject
Brain ventricle
Cerebrospinal fluid
Computational fluid dynamics
Flow mixing
Magnetic resonance imaging
Description
Maeda S., Otani T., Yamada S., et al. Biomechanical effects of hyper-dynamic cerebrospinal fluid flow through the cerebral aqueduct in idiopathic normal pressure hydrocephalus patients. Journal of Biomechanics 156, 111671 (2023); https://doi.org/10.1016/j.jbiomech.2023.111671.
Abstract
Normal pressure hydrocephalus (NPH) is an intracranial disease characterized by an abnormal accumulation of cerebrospinal fluid (CSF) in brain ventricles within the normal range of intracranial pressure. Most NPH in aged patients is idiopathic (iNPH) and without any prior history of intracranial diseases. Although an abnormal increase of CSF stroke volume (hyper-dynamic CSF flow) in the aqueduct between the third and fourth ventricles has received much attention as a clinical evaluation index in iNPH patients, the biomechanical effects of this flow on iNPH pathophysiology are poorly understood. This study aimed to clarify the potential biomechanical effects of hyper-dynamic CSF flow through the aqueduct of iNPH patients using magnetic resonance imaging-based computational simulations. Ventricular geometries and CSF flow rates through aqueducts of 10 iNPH patients and 10 healthy control subjects were obtained from multimodal magnetic resonance images, and these CSF flow fields were simulated using computational fluid dynamics. As biomechanical factors, we evaluated wall shear stress on the ventricular wall and the extent of flow mixing, which potentially disturbs the CSF composition in each ventricle. The results showed that the relatively high CSF flow rate and large and irregular shapes of the aqueduct in iNPH resulted in large wall shear stresses localized in relatively narrow regions. Furthermore, the resulting CSF flow showed a stable cyclic motion in control subjects, whereas strong mixing during transport through the aqueduct was found in patients with iNPH. These findings provide further insights into the clinical and biomechanical correlates of NPH pathophysiology.
Publisher
Elsevier
Source Title
Journal of Biomechanics
Volume (Issue)
156
Page
111671
Date of Issued
2023-07
Language
English
Handle URL
https://hdl.handle.net/11094/92339
PISSN
00219290
eISSN
18732380
NCID
AA00694200
Relation.isVersionOf
DOI (Publisher Version)
https://doi.org/10.1016/j.jbiomech.2023.111671
CopyRight
© 2023. This manuscript version is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
The full-text file will be made open to the public on 14 June 2024 in accordance with the publisher's policy.
oaire:version
Accepted Manuscript
Category
学術雑誌論文 Journal Article