Association between high cardiac output at altitude and acute mountain sickness: preliminary study on Mt. Fuji

Ebihara, Takeshi; Shimizu, Kentaro; Mitsuyama, Yumi et al.

Journal of Physiological Anthropology, 2023, 42, 6

Number of Access:944（2025-08-16 03:17 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/92528

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Title
Association between high cardiac output at altitude and acute mountain sickness: preliminary study on Mt. Fuji
Creator
NRID
1000010813975 1000010813975
ORCID
0000-0003-4101-0419 0000-0003-4101-0419
researchmap permalink
ebihara830 ebihara830
CreatorName
Ebihara, Takeshi
NRID
1000060379203 1000060379203
researchmap permalink
kentaroshimizu kentaroshimizu
Scopus Author ID
55303276200 55303276200
CreatorName
Shimizu, Kentaro
CreatorName
Mitsuyama, Yumi
NRID
1000070301265 1000070301265
researchmap permalink
read0054647 read0054647
Scopus Author ID
7202495132 7202495132
CreatorName
Ogura, Hiroshi
NRID
1000060459500 1000060459500
ORCID
0000-0002-8254-3716 0000-0002-8254-3716
researchmap permalink
read0068529 read0068529
Scopus Author ID
56210537000 56210537000
CreatorName
Oda, Jun
Subject
Cardiac function
Mt. Fuji
Mt. Fuji research station
Non-invasive hemodynamic monitor
Description
Ebihara T., Shimizu K., Mitsuyama Y., et al. Association between high cardiac output at altitude and acute mountain sickness: preliminary study on Mt. Fuji. Journal of Physiological Anthropology 42, 6 (2023); https://doi.org/10.1186/s40101-023-00322-7.
Abstract
Background: Acute mountain sickness (AMS) affects around 30% of people climbing Mt. Fuji, but its pathogenesis is incompletely understood. The influence of a rapid ascent to high altitude by climbing and summiting Mt. Fuji on cardiac function in the general population is unknown, and its association with altitude sickness has not been clarified. Methods: Subjects climbing Mt. Fuji were included. Heart rate, oxygen saturation, systolic blood pressure, cardiac index (CI) and stroke volume index were measured multiple times at 120 m as baseline values and at Mt. Fuji Research Station (MFRS) at 3,775 m. Each value and its difference from the baseline value (Δ) of subjects with AMS (defined as Lake Louise Score [LLS] ≥ 3 with headache after sleeping at 3,775 m) were compared with those of non-AMS subjects. Results: Eleven volunteers who climbed from 2,380 m to MFRS within 8 h and stayed overnight at MFRS were included. Four suffered AMS. Compared with the non-AMS subjects, CI in the AMS subjects was significantly higher than that before sleeping (median [interquartile range]: 4.9 [4.5, 5.0] vs. 3.8 [3.4, 3.9] mL/min/m2; p = 0.04), and their ΔCI was significantly higher before sleeping (1.6 [1.4, 2.1] vs. 0.2 [0.0, 0.7] mL/min/m2; p < 0.01) and after sleeping (0.7 [0.3, 1.7] vs. -0.2 [-0.5, 0.0] mL/min/m2; p < 0.01). ΔCI in the AMS subjects dropped significantly after sleeping versus before sleeping (3.8 [3.6, 4.5] vs. 4.9 [4.5, 5.0] mL/min/m2; p = 0.04). Conclusions: Higher values of CI and ΔCI were observed at high altitude in the AMS subjects. A high cardiac output might be associated with the development of AMS.
Publisher
BioMed Central Ltd
Source Title
Journal of Physiological Anthropology
Volume (Issue)
42
Page
6
Date of Issued
2023-04-13
Language
English
Handle URL
https://hdl.handle.net/11094/92528
PISSN
18806791
eISSN
18806805
Relation.isIdenticalTo
DOI (Publisher Version)
https://doi.org/10.1186/s40101-023-00322-7
Access Rights
open access
CopyRight
This article is licensed under a Creative Commons Attribution 4.0 International License.
oaire:version
Version of Record
Category
学術雑誌論文 Journal Article