Copper-Catalyzed Electrophilic Amination: An Umpolung Strategy for New CN Bond Formations

Hirano, Koji

Bulletin of the Chemical Society of Japan, 2023, 96(3), 198-207

Number of Access:257（2025-07-17 20:20 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/92800

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Title
Copper-Catalyzed Electrophilic Amination: An Umpolung Strategy for New CN Bond Formations
Creator
NRID
1000070532696 1000070532696
ORCID
0000-0001-9752-1985 0000-0001-9752-1985
researchmap permalink
koj koj
Scopus Author ID
7402407063 7402407063
CreatorName
Hirano, Koji
Subject
Amination
Copper
Umpolung
Abstract
The nitrogen atom is ubiquitous in bioactive molecules and functional materials, and the development of new CN bond forming strategies is thus one of the long-standing research subjects in the synthetic community. This account describes the nitrogen-umpolung-enabled copper-catalyzed highly chemo- and stereoselective amination protocols developed by the author’s research group. Starting from the CH amination, electrophilic amination of stable organoboron and organosilicon compounds, aminoboration/hydroamination of alkenes, and their applications to the synthesis of functionality-rich alkylamines are shown. The reaction design, concept, and substrate scope are briefly summarized.
Publisher
Chemical Society of Japan
Source Title
Bulletin of the Chemical Society of Japan
Volume (Issue)
96(3)
Page
198-207
Date of Issued
2023-03-01
Language
English
Handle URL
https://hdl.handle.net/11094/92800
PISSN
00092673
eISSN
13480634
NCID
AA00580132
Relation.isVersionOf
DOI (Publisher Version)
https://doi.org/10.1246/bcsj.20230003
Access Rights
open access
CopyRight
© 2023 The Chemical Society of Japan.
oaire:version
Accepted Manuscript
Category
学術雑誌論文 Journal Article