Quantitative Threshold Determination of Auditory Brainstem Responses in Mouse Models

Tanaka, Kenji; Ohara, Shuma; Matsuzaka, Tadaaki; Matsugaki, Aira; Ishimoto, Takuya; Ozasa, Ryosuke; Kuroda, Yukiko; Matsuo, Koichi; Nakano, Takayoshi

doi:https://doi.org/10.3390/ijms241411393

Quantitative Threshold Determination of Auditory Brainstem Responses in Mouse Models

Tanaka, Kenji; Ohara, Shuma; Matsuzaka, Tadaaki et al.

International Journal of Molecular Sciences, 2023, 24(14), 11393

Number of Access:550（2025-07-16 18:39 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/93113

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Title	Quantitative Threshold Determination of Auditory Brainstem Responses in Mouse Models
Creator	CreatorName Tanaka, Kenji
	CreatorName Ohara, Shuma
	CreatorName Matsuzaka, Tadaaki
	NRID 1000010592529 1000010592529 ORCID 0000-0002-8427-7124 0000-0002-8427-7124 researchmap permalink aira aira Scopus Author ID 24172720900 24172720900 CreatorName Matsugaki, Aira
	NRID 1000050508835 1000050508835 ORCID 0000-0003-0081-0591 0000-0003-0081-0591 researchmap permalink i_taku i_taku Scopus Author ID 35310484700 35310484700 CreatorName Ishimoto, Takuya
	NRID 1000080845347 1000080845347 ORCID 0000-0002-2773-072X 0000-0002-2773-072X researchmap permalink ozasa_r ozasa_r Scopus Author ID 56202812400 56202812400 CreatorName Ozasa, Ryosuke
	NRID 1000070455343 1000070455343 CreatorName Kuroda, Yukiko
	NRID 1000040229422 1000040229422 CreatorName Matsuo, Koichi
	NRID 1000030243182 1000030243182 ORCID 0000-0001-8052-1698 0000-0001-8052-1698 researchmap permalink read0013987 read0013987 Scopus Author ID 7403896013 7403896013 CreatorName Nakano, Takayoshi
Subject	ABR threshold
	auditory brainstem responses (ABR)
	auditory function
	correlation coefficient
	cross-covariance
Description	Tanaka K., Ohara S., Matsuzaka T., et al. Quantitative Threshold Determination of Auditory Brainstem Responses in Mouse Models. International Journal of Molecular Sciences 24, 11393 (2023); https://doi.org/10.3390/ijms241411393.
Abstract	The auditory brainstem response (ABR) is a scalp recording of potentials produced by sound stimulation, and is commonly used as an indicator of auditory function. However, the ABR threshold, which is the lowest audible sound pressure, cannot be objectively determined since it is determined visually using a measurer, and this has been a problem for several decades. Although various algorithms have been developed to objectively determine ABR thresholds, they remain lacking in terms of accuracy, efficiency, and convenience. Accordingly, we proposed an improved algorithm based on the mutual covariance at adjacent sound pressure levels. An ideal ABR waveform with clearly defined waves I–V was created; moreover, using this waveform as a standard template, the experimentally obtained ABR waveform was inspected for disturbances based on mutual covariance. The ABR testing was repeated if the value was below the established cross-covariance reference value. Our proposed method allowed more efficient objective determination of ABR thresholds and a smaller burden on experimental animals.
Publisher	Multidisciplinary Digital Publishing Institute (MDPI)
Source Title	International Journal of Molecular Sciences
Volume (Issue)	24(14)
Page	11393
Date of Issued	2023-07-13
Language	English
Handle URL	https://hdl.handle.net/11094/93113
PISSN	16616596
eISSN	14220067
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.3390/ijms241411393
Access Rights	open access
CopyRight	This article is licensed under a Creative Commons Attribution 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCMI Type	Text
DCTERMS.bibliographicCitation	International Journal of Molecular Sciences. 2023, 24(14), p. 11393
DC.title	Quantitative Threshold Determination of Auditory Brainstem Responses in Mouse Models
DC.creator	Tanaka, Kenji
	Ohara, Shuma
	Matsuzaka, Tadaaki
	Matsugaki, Aira
	Ishimoto, Takuya
	Ozasa, Ryosuke
	Kuroda, Yukiko
	Matsuo, Koichi
	Nakano, Takayoshi
DC.publisher	Multidisciplinary Digital Publishing Institute (MDPI)
DC.language' scheme='DCTERMS.RFC1766	English
DC.type' scheme='DCTERMS.DCMIType	Text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2023-07-13
DC.identifier	https://doi.org/10.3390/ijms241411393
DC.subject	ABR threshold
	auditory brainstem responses (ABR)
	auditory function
	correlation coefficient
	cross-covariance
DC.description	Tanaka K., Ohara S., Matsuzaka T., et al. Quantitative Threshold Determination of Auditory Brainstem Responses in Mouse Models. International Journal of Molecular Sciences 24, 11393 (2023); https://doi.org/10.3390/ijms241411393.
DCTERMS.abstract	The auditory brainstem response (ABR) is a scalp recording of potentials produced by sound stimulation, and is commonly used as an indicator of auditory function. However, the ABR threshold, which is the lowest audible sound pressure, cannot be objectively determined since it is determined visually using a measurer, and this has been a problem for several decades. Although various algorithms have been developed to objectively determine ABR thresholds, they remain lacking in terms of accuracy, efficiency, and convenience. Accordingly, we proposed an improved algorithm based on the mutual covariance at adjacent sound pressure levels. An ideal ABR waveform with clearly defined waves I–V was created; moreover, using this waveform as a standard template, the experimentally obtained ABR waveform was inspected for disturbances based on mutual covariance. The ABR testing was repeated if the value was below the established cross-covariance reference value. Our proposed method allowed more efficient objective determination of ABR thresholds and a smaller burden on experimental animals.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	93113
citation_title	Quantitative Threshold Determination of Auditory Brainstem Responses in Mouse Models
citation_author	Tanaka, Kenji
	Ohara, Shuma
	Matsuzaka, Tadaaki
	Matsugaki, Aira
	Ishimoto, Takuya
	Ozasa, Ryosuke
	Kuroda, Yukiko
	Matsuo, Koichi
	Nakano, Takayoshi
citation_publisher	Multidisciplinary Digital Publishing Institute (MDPI)
citation_language	English
citation_date	2023-07-13
citation_journal_title	International Journal of Molecular Sciences
citation_volume	24
citation_issue	14
citation_firstpage	11393
citation_doi	https://doi.org/10.3390/ijms241411393
citation_public_url	https://hdl.handle.net/11094/93113

Quantitative Threshold Determination of Auditory Brainstem Responses in Mouse Models

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