In vivo induction of activin A-producing alveolar macrophages supports the progression of lung cell carcinoma

Taniguchi, Seiji; Matsui, Takahiro; Kimura, Kenji; Funaki, Soichiro; Miyamoto, Yu; Uchida, Yutaka; Sudo, Takao; Kikuta, Junichi; Hara, Tetsuya; Motooka, Daisuke; Liu, Yu Chen; Okuzaki, Daisuke; Morii, Eiichi; Emoto, Noriaki; Shintani, Yasushi; Ishii, Masaru

doi:https://doi.org/10.1038/s41467-022-35701-8

In vivo induction of activin A-producing alveolar macrophages supports the progression of lung cell carcinoma

Taniguchi, Seiji; Matsui, Takahiro; Kimura, Kenji et al.

Nature Communications, 2023, 14(1), 143

Number of Access:2,478（2025-07-18 12:20 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/93152

Link to primary information

File	Format	Terms of use	Size	Views	Date.Available	Description	information
NatCommun_14_1	pdf	None	4.17 MB	92	2023.11.17

Creative Commons : Attribution

Item Information

Output File Export EndNote Basic Export Mendeley

Title	In vivo induction of activin A-producing alveolar macrophages supports the progression of lung cell carcinoma
Creator	NRID 1000050836252 1000050836252 CreatorName Taniguchi, Seiji
	NRID 1000050747037 1000050747037 ORCID 0000-0002-6753-1688 0000-0002-6753-1688 researchmap permalink takahiromatsui takahiromatsui Scopus Author ID 35176152500 35176152500 CreatorName Matsui, Takahiro
	NRID 1000050795325 1000050795325 CreatorName Kimura, Kenji
	NRID 1000050464251 1000050464251 researchmap permalink so1 so1 Scopus Author ID 14123352700 14123352700 CreatorName Funaki, Soichiro
	NRID 1000090965336 1000090965336 researchmap permalink yumiyamoto yumiyamoto ORCID 0000-0002-2715-6465 0000-0002-2715-6465 CreatorName Miyamoto, Yu
	NRID 1000050833787 1000050833787 researchmap permalink YutakaUchida YutakaUchida Scopus Author ID 56967526600 56967526600 CreatorName Uchida, Yutaka
	NRID 1000080631184 1000080631184 researchmap permalink kik kik Scopus Author ID 36497716100 36497716100 CreatorName Sudo, Takao
	NRID 1000060710069 1000060710069 researchmap permalink jkikuta jkikuta Scopus Author ID 36637603800 36637603800 CreatorName Kikuta, Junichi
	NRID 1000070547504 1000070547504 CreatorName Hara, Tetsuya
	NRID 1000010636830 1000010636830 researchmap permalink daisukem daisukem Scopus Author ID 35315737900 35315737900 CreatorName Motooka, Daisuke
	NRID 1000050894698 1000050894698 ORCID 0000-0002-2750-0182 0000-0002-2750-0182 researchmap permalink liuyuchen liuyuchen CreatorName Liu, Yu Chen
	NRID 1000000346131 1000000346131 ORCID 0000-0002-4552-783X 0000-0002-4552-783X researchmap permalink read0092307 read0092307 Scopus Author ID 6506703054 6506703054 CreatorName Okuzaki, Daisuke
	NRID 1000010283772 1000010283772 ORCID 0000-0001-8490-3650 0000-0001-8490-3650 researchmap permalink read0046454 read0046454 Scopus Author ID 7003914326 7003914326 CreatorName Morii, Eiichi
	NRID 1000030294218 1000030294218 CreatorName Emoto, Noriaki
	NRID 1000090572983 1000090572983 researchmap permalink shintani6384 shintani6384 Scopus Author ID 7103142734 7103142734 CreatorName Shintani, Yasushi
	NRID 1000010324758 1000010324758 researchmap permalink read0076684 read0076684 Scopus Author ID 35074093500 35074093500 CreatorName Ishii, Masaru
Description	Taniguchi S., Matsui T., Kimura K., et al. In vivo induction of activin A-producing alveolar macrophages supports the progression of lung cell carcinoma. Nature Communications 14, 143 (2023); https://doi.org/10.1038/s41467-022-35701-8.
Abstract	Alveolar macrophages (AMs) are crucial for maintaining normal lung function. They are abundant in lung cancer tissues, but their pathophysiological significance remains unknown. Here we show, using an orthotopic murine lung cancer model and human carcinoma samples, that AMs support cancer cell proliferation and thus contribute to unfavourable outcome. Inhibin beta A (INHBA) expression is upregulated in AMs under tumor-bearing conditions, leading to the secretion of activin A, a homodimer of INHBA. Accordingly, follistatin, an antagonist of activin A is able to inhibit lung cancer cell proliferation. Single-cell RNA sequence analysis identifies a characteristic subset of AMs specifically induced in the tumor environment that are abundant in INHBA, and distinct from INHBA-expressing AMs in normal lungs. Moreover, postnatal deletion of INHBA/activin A could limit tumor growth in experimental models. Collectively, our findings demonstrate the critical pathological role of activin A-producing AMs in tumorigenesis, and provides means to clearly distinguish them from their healthy counterparts.
Publisher	Nature Research
Source Title	Nature Communications
Volume (Issue)	14(1)
Page	143
Date of Issued	2023-01-17
Language	English
Handle URL	https://hdl.handle.net/11094/93152
eISSN	20411723
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1038/s41467-022-35701-8
Access Rights	open access
CopyRight	This article is licensed under a Creative Commons Attribution 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCMI Type	Text
DCTERMS.bibliographicCitation	Nature Communications. 2023, 14(1), p. 143
DC.title	In vivo induction of activin A-producing alveolar macrophages supports the progression of lung cell carcinoma
DC.creator	Taniguchi, Seiji
	Matsui, Takahiro
	Kimura, Kenji
	Funaki, Soichiro
	Miyamoto, Yu
	Uchida, Yutaka
	Sudo, Takao
	Kikuta, Junichi
	Hara, Tetsuya
	Motooka, Daisuke
	Liu, Yu Chen
	Okuzaki, Daisuke
	Morii, Eiichi
	Emoto, Noriaki
	Shintani, Yasushi
	Ishii, Masaru
DC.publisher	Nature Research
DC.language' scheme='DCTERMS.RFC1766	English
DC.type' scheme='DCTERMS.DCMIType	Text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2023-01-17
DC.identifier	https://doi.org/10.1038/s41467-022-35701-8
DC.description	Taniguchi S., Matsui T., Kimura K., et al. In vivo induction of activin A-producing alveolar macrophages supports the progression of lung cell carcinoma. Nature Communications 14, 143 (2023); https://doi.org/10.1038/s41467-022-35701-8.
DCTERMS.abstract	Alveolar macrophages (AMs) are crucial for maintaining normal lung function. They are abundant in lung cancer tissues, but their pathophysiological significance remains unknown. Here we show, using an orthotopic murine lung cancer model and human carcinoma samples, that AMs support cancer cell proliferation and thus contribute to unfavourable outcome. Inhibin beta A (INHBA) expression is upregulated in AMs under tumor-bearing conditions, leading to the secretion of activin A, a homodimer of INHBA. Accordingly, follistatin, an antagonist of activin A is able to inhibit lung cancer cell proliferation. Single-cell RNA sequence analysis identifies a characteristic subset of AMs specifically induced in the tumor environment that are abundant in INHBA, and distinct from INHBA-expressing AMs in normal lungs. Moreover, postnatal deletion of INHBA/activin A could limit tumor growth in experimental models. Collectively, our findings demonstrate the critical pathological role of activin A-producing AMs in tumorigenesis, and provides means to clearly distinguish them from their healthy counterparts.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	93152
citation_title	In vivo induction of activin A-producing alveolar macrophages supports the progression of lung cell carcinoma
citation_author	Taniguchi, Seiji
	Matsui, Takahiro
	Kimura, Kenji
	Funaki, Soichiro
	Miyamoto, Yu
	Uchida, Yutaka
	Sudo, Takao
	Kikuta, Junichi
	Hara, Tetsuya
	Motooka, Daisuke
	Liu, Yu Chen
	Okuzaki, Daisuke
	Morii, Eiichi
	Emoto, Noriaki
	Shintani, Yasushi
	Ishii, Masaru
citation_publisher	Nature Research
citation_language	English
citation_date	2023-01-17
citation_journal_title	Nature Communications
citation_volume	14
citation_issue	1
citation_firstpage	143
citation_doi	https://doi.org/10.1038/s41467-022-35701-8
citation_public_url	https://hdl.handle.net/11094/93152

In vivo induction of activin A-producing alveolar macrophages supports the progression of lung cell carcinoma

Link to primary information

Item Information

Show details