The effects of vitamin D on immune system and inflammatory diseases

Ao, Tomoka; Kikuta, Junichi; Ishii, Masaru

Biomolecules, 2021, 11(11), 1624

Number of Access:608（2025-08-18 12:29 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/93155

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Title
The effects of vitamin D on immune system and inflammatory diseases
Creator
NRID
1000090880865 1000090880865
researchmap permalink
tomoka_ao1203 tomoka_ao1203
CreatorName
Ao, Tomoka
NRID
1000060710069 1000060710069
researchmap permalink
jkikuta jkikuta
Scopus Author ID
36637603800 36637603800
CreatorName
Kikuta, Junichi
NRID
1000010324758 1000010324758
researchmap permalink
read0076684 read0076684
Scopus Author ID
35074093500 35074093500
CreatorName
Ishii, Masaru
Subject
COVID-19
Immune system
Multiple sclerosis (MS)
Rheumatoid arthritis (RA)
Systemic lupus erythematosus (SLE)
Vitamin D
Description
Ao T., Kikuta J., Ishii M.. The effects of vitamin D on immune system and inflammatory diseases. Biomolecules 11, 1624 (2021); https://doi.org/10.3390/biom11111624.
Abstract
Immune cells, including dendritic cells, macrophages, and T and B cells, express the vitamin D receptor and 1α-hydroxylase. In vitro studies have shown that 1,25-dihydroxyvitamin D, the active form of vitamin D, has an anti-inflammatory effect. Recent epidemiological evidence has indicated a significant association between vitamin D deficiency and an increased incidence, or aggravation, of infectious diseases and inflammatory autoimmune diseases, such as rheumatoid arthritis, systemic lupus erythematosus, and multiple sclerosis. However, the impact of vitamin D on treatment and prevention, particularly in infectious diseases such as the 2019 coronavirus disease (COVID-19), remains controversial. Here, we review recent evidence associated with the relationship between vitamin D and inflammatory diseases and describe the underlying immunomodulatory effect of vitamin D.
Publisher
MDPI
Source Title
Biomolecules
Volume (Issue)
11(11)
Page
1624
Date of Issued
2021-11-03
Language
English
Handle URL
https://hdl.handle.net/11094/93155
eISSN
2218273X
Relation.isIdenticalTo
DOI (Publisher Version)
https://doi.org/10.3390/biom11111624
Access Rights
open access
CopyRight
This article is licensed under a Creative Commons Attribution 4.0 International License.
oaire:version
Version of Record
Category
学術雑誌論文 Journal Article