Group 2 innate lymphoid cells support hematopoietic recovery under stress conditions

Sudo, Takao; Motomura, Yasutaka; Okuzaki, Daisuke; Hasegawa, Tetsuo; Yokota, Takafumi; Kikuta, Junichi; Ao, Tomoka; Mizuno, Hiroki; Matsui, Takahiro; Motooka, Daisuke; Yoshizawa, Ryosuke; Nagasawa, Takashi; Kanakura, Yuzuru; Moro, Kazuyo; Ishii, Masaru

doi:https://doi.org/10.1084/jem.20200817

Group 2 innate lymphoid cells support hematopoietic recovery under stress conditions

Sudo, Takao; Motomura, Yasutaka; Okuzaki, Daisuke et al.

Journal of Experimental Medicine, 2021, 218(5), e20200817

Number of Access:2,273（2025-07-24 04:46 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/93159

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Title	Group 2 innate lymphoid cells support hematopoietic recovery under stress conditions
Creator	NRID 1000080631184 1000080631184 researchmap permalink kik kik Scopus Author ID 36497716100 36497716100 CreatorName Sudo, Takao
	NRID 1000010587794 1000010587794 ORCID 0000-0003-1088-9985 0000-0003-1088-9985 researchmap permalink yasutaka_motomura yasutaka_motomura Scopus Author ID 23036180600 23036180600 CreatorName Motomura, Yasutaka
	NRID 1000000346131 1000000346131 ORCID 0000-0002-4552-783X 0000-0002-4552-783X researchmap permalink read0092307 read0092307 Scopus Author ID 6506703054 6506703054 CreatorName Okuzaki, Daisuke
	NRID 1000030773048 1000030773048 CreatorName Hasegawa, Tetsuo
	NRID 1000060403200 1000060403200 researchmap permalink 6000022404 6000022404 Scopus Author ID 7402558170 7402558170 CreatorName Yokota, Takafumi
	NRID 1000060710069 1000060710069 researchmap permalink jkikuta jkikuta Scopus Author ID 36637603800 36637603800 CreatorName Kikuta, Junichi
	NRID 1000090880865 1000090880865 researchmap permalink tomoka_ao1203 tomoka_ao1203 CreatorName Ao, Tomoka
	NRID 1000090707655 1000090707655 CreatorName Mizuno, Hiroki
	NRID 1000050747037 1000050747037 ORCID 0000-0002-6753-1688 0000-0002-6753-1688 researchmap permalink takahiromatsui takahiromatsui Scopus Author ID 35176152500 35176152500 CreatorName Matsui, Takahiro
	NRID 1000010636830 1000010636830 researchmap permalink daisukem daisukem Scopus Author ID 35315737900 35315737900 CreatorName Motooka, Daisuke
	CreatorName Yoshizawa, Ryosuke
	NRID 1000080281690 1000080281690 ORCID 0000-0002-1085-0960 0000-0002-1085-0960 researchmap permalink read0094728 read0094728 Scopus Author ID 35196507500 35196507500 CreatorName Nagasawa, Takashi
	NRID 1000020177489 1000020177489 CreatorName Kanakura, Yuzuru
	NRID 1000090468489 1000090468489 ORCID 0000-0002-7377-1303 0000-0002-7377-1303 researchmap permalink kazuyomoro kazuyomoro Scopus Author ID 16638841900 16638841900 CreatorName Moro, Kazuyo
	NRID 1000010324758 1000010324758 researchmap permalink read0076684 read0076684 Scopus Author ID 35074093500 35074093500 CreatorName Ishii, Masaru
Description	Sudo T., Motomura Y., Okuzaki D., et al. Group 2 innate lymphoid cells support hematopoietic recovery under stress conditions. Journal of Experimental Medicine 218, e20200817 (2021); https://doi.org/10.1084/jem.20200817.
Abstract	The cell-cycle status of hematopoietic stem and progenitor cells (HSPCs) becomes activated following chemotherapy-induced stress, promoting bone marrow (BM) regeneration; however, the underlying molecular mechanism remains elusive. Here we show that BM-resident group 2 innate lymphoid cells (ILC2s) support the recovery of HSPCs from 5-fluorouracil (5-FU)-induced stress by secreting granulocyte-macrophage colony-stimulating factor (GM-CSF). Mechanistically, IL-33 released from chemosensitive B cell progenitors activates MyD88-mediated secretion of GM-CSF in ILC2, suggesting the existence of a B cell-ILC2 axis for maintaining hematopoietic homeostasis. GM-CSF knockout mice treated with 5-FU showed severe loss of myeloid lineage cells, causing lethality, which was rescued by transferring BM ILC2s from wild-type mice. Further, the adoptive transfer of ILC2s to 5-FU-treated mice accelerates hematopoietic recovery, while the reduction of ILC2s results in the opposite effect. Thus, ILC2s may function by "sensing" the damaged BM spaces and subsequently support hematopoietic recovery under stress conditions.
Publisher	Rockefeller University Press
Source Title	Journal of Experimental Medicine
Volume (Issue)	218(5)
Page	e20200817
Date of Issued	2021-05-03
Language	English
Handle URL	https://hdl.handle.net/11094/93159
PISSN	00221007
eISSN	15409538
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1084/jem.20200817
Access Rights	open access
CopyRight	This article is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCMI Type	Text
DCTERMS.bibliographicCitation	Journal of Experimental Medicine. 2021, 218(5), p. e20200817
DC.title	Group 2 innate lymphoid cells support hematopoietic recovery under stress conditions
DC.creator	Sudo, Takao
	Motomura, Yasutaka
	Okuzaki, Daisuke
	Hasegawa, Tetsuo
	Yokota, Takafumi
	Kikuta, Junichi
	Ao, Tomoka
	Mizuno, Hiroki
	Matsui, Takahiro
	Motooka, Daisuke
	Yoshizawa, Ryosuke
	Nagasawa, Takashi
	Kanakura, Yuzuru
	Moro, Kazuyo
	Ishii, Masaru
DC.publisher	Rockefeller University Press
DC.language' scheme='DCTERMS.RFC1766	English
DC.type' scheme='DCTERMS.DCMIType	Text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2021-05-03
DC.identifier	https://doi.org/10.1084/jem.20200817
DC.description	Sudo T., Motomura Y., Okuzaki D., et al. Group 2 innate lymphoid cells support hematopoietic recovery under stress conditions. Journal of Experimental Medicine 218, e20200817 (2021); https://doi.org/10.1084/jem.20200817.
DCTERMS.abstract	The cell-cycle status of hematopoietic stem and progenitor cells (HSPCs) becomes activated following chemotherapy-induced stress, promoting bone marrow (BM) regeneration; however, the underlying molecular mechanism remains elusive. Here we show that BM-resident group 2 innate lymphoid cells (ILC2s) support the recovery of HSPCs from 5-fluorouracil (5-FU)-induced stress by secreting granulocyte-macrophage colony-stimulating factor (GM-CSF). Mechanistically, IL-33 released from chemosensitive B cell progenitors activates MyD88-mediated secretion of GM-CSF in ILC2, suggesting the existence of a B cell-ILC2 axis for maintaining hematopoietic homeostasis. GM-CSF knockout mice treated with 5-FU showed severe loss of myeloid lineage cells, causing lethality, which was rescued by transferring BM ILC2s from wild-type mice. Further, the adoptive transfer of ILC2s to 5-FU-treated mice accelerates hematopoietic recovery, while the reduction of ILC2s results in the opposite effect. Thus, ILC2s may function by "sensing" the damaged BM spaces and subsequently support hematopoietic recovery under stress conditions.
DC.rights	This article is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
DC.format	93159
citation_title	Group 2 innate lymphoid cells support hematopoietic recovery under stress conditions
citation_author	Sudo, Takao
	Motomura, Yasutaka
	Okuzaki, Daisuke
	Hasegawa, Tetsuo
	Yokota, Takafumi
	Kikuta, Junichi
	Ao, Tomoka
	Mizuno, Hiroki
	Matsui, Takahiro
	Motooka, Daisuke
	Yoshizawa, Ryosuke
	Nagasawa, Takashi
	Kanakura, Yuzuru
	Moro, Kazuyo
	Ishii, Masaru
citation_publisher	Rockefeller University Press
citation_language	English
citation_date	2021-05-03
citation_journal_title	Journal of Experimental Medicine
citation_volume	218
citation_issue	5
citation_firstpage	e20200817
citation_doi	https://doi.org/10.1084/jem.20200817
citation_public_url	https://hdl.handle.net/11094/93159

Group 2 innate lymphoid cells support hematopoietic recovery under stress conditions

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